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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic, beta-3-, receptor

beta3-adrenergic receptor, beta3-adrenoceptor, ADRB3, beta3-AR, beta3-adrenergic receptor gene
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: Insulin, beta2, HAD, fibrillin-1, ACID
Papers on beta3-adrenergic receptor
Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue.
New
Granneman et al., Inch'ŏn, South Korea. In Am J Physiol Regul Integr Comp Physiol, Feb 2016
We previously demonstrated that treatment with a β3-adrenergic receptor (ADRB3) agonist triggers brown/beige adipogenesis in gonadal white adipose tissue following adipocyte death and clearance by tissue macrophages.
The role of genes involved in lipolysis on weight loss program in overweight and obese individuals.
Review
New
Susilowati et al., Yogyakarta, Indonesia. In J Clin Biochem Nutr, Sep 2015
Single Nucleotide Polymorphism (SNP) in PLIN (11482G>A) and ADRB3 (Trp64Arg) are the most studied polymorphisms that have effect on weight loss intervention.
[Study on relationship between Trp64Arg polymorphism of β3-adrenergic receptor gene and obesity and blood lipids].
New
Wen et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To investigate the relationship between the Trp64Arg polymorphism of β3-adrenergic receptor (ADRB3) gene and obesity and the levels of blood lipids in the Northern Han Chinese population.
Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.
Review
New
Khullar et al., London, United Kingdom. In Am J Obstet Gynecol, Feb 2015
RESULTS: In pooled analysis, the rs4994 polymorphism of the ADRB3 gene was associated with overactive bladder (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.7-3.6;
A framework radiation hybrid map of buffalo chromosome 1 ordering scaffolds from buffalo genome sequence assembly.
Amaral-Trusty et al., Ribeirão Preto, Brazil. In Genet Mol Res, 2014
In this study, we constructed a new framework radiation hybrid (RH) map from BBU1 using BBURH5000 panel adding nine new genes (ADRB3, ATP2C1, COPB2, CRYGS, P2RY1, SLC5A3, SLC20A2, SST, and ZDHHC2) and one microsatellite (CSSM043) to the set of markers previously mapped on BBU1.
Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions.
Nishimori et al., Japan. In Front Endocrinol (lausanne), 2014
Additionally, increased expression of the β3-adrenergic receptor gene, Adrb3, was observed in BAT.
A Multiple Interaction Analysis Reveals ADRB3 as a Potential Candidate for Gallbladder Cancer Predisposition via a Complex Interaction with Other Candidate Gene Variations.
Mittal et al., Kyŏngsan, South Korea. In Int J Mol Sci, 2014
Here, we performed Multifactor-Dimensionality Reduction (MDR) and Classification and Regression Tree Analysis (CRT) to investigate the gene-gene interactions and the combined effect of 14 SNPs in nine genes (DR4 (rs20576, rs6557634); FAS (rs2234767); FASL (rs763110); DCC (rs2229080, rs4078288, rs7504990, rs714); PSCA (rs2294008, rs2978974); ADRA2A (rs1801253); ADRB1 (rs1800544); ADRB3 (rs4994); CYP17 (rs2486758)) involved in various signaling pathways.
Identification of an adipogenic niche for adipose tissue remodeling and restoration.
Impact
Granneman et al., Detroit, United States. In Cell Metab, 2013
We report that induction of brown adipogenesis by β3-adrenergic receptor (ADRB3) activation involves the death of white adipocytes and their removal by M2-polarized macrophages.
Future therapies: Early trials and basic science.
Review
Andersson, Winston-Salem, United States. In Can Urol Assoc J, 2013
Pharmacotherapeutic options for overactive bladder (OAB) include antimuscarinics and the beta3-adrenoceptor agonist mirabegron.
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.
Impact
Kulkarni et al., Boston, United States. In Nat Med, 2013
Adipocytes of these knockout mice showed greater stimulated lipolysis secondary to enhanced expression of hormone sensitive lipase (HSL) and β3-adrenergic (Adrb3) receptors.
[Overactive bladder--a new insight into the pathogenesis of its idiopathic form].
Review
Rechberger et al., Poland. In Ginekol Pol, 2012
Density of beta-3 AR is very high in urinary bladder detrusor Activation of beta-3 AR leads to the relaxation of smooth muscle fibers during the filling phase and is cAMP-dependent.
Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.
GeneRIF
Summers et al., Australia. In J Biol Chem, 2012
interaction of the beta(3a)-AR with caveolin inhibits coupling to Galpha(i/o) proteins and suggest that signaling is modulated by a raft-enriched complex containing the beta(3a)-AR, caveolin-1, Galpha(s), and adenylyl cyclase.
Interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patients.
GeneRIF
Castro et al., Valladolid, Spain. In Eur Rev Med Pharmacol Sci, 2012
Report interaction of -55CT polymorphism of UCP3 gene with Trp64Arg polymorphism of beta3adrenoreceptor gene on insulin resistance in obese patients.
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding.
Impact
GeneRIF
Granneman et al., Detroit, United States. In Cell Metab, 2012
Brown adipocytes that are induced by beta3-adrenergic receptor activation in abdominal white adipose tissue arise from the proliferation and differentiation of cells expressing PDGFRalpha, CD34, and Sca-1.
ADRB3 polymorphism associated with BMI gain in Japanese men.
GeneRIF
Kuroda et al., Miyazaki, Japan. In Exp Diabetes Res, 2011
The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.
[The Trp64Arg polymorphism of beta3-adrenoreceptor gene study in persons with overweight and obesity].
GeneRIF
Tutel'ian et al., In Vopr Pitan, 2011
Trp64Arg genotypes of ADRB3 compared to Trp64Trp genotypes had significantly higher body fat percentage, serum glucose and uric acid concentrations.
[Association of BMI with the beta3 adrenergic receptor gene mutation: a meta-analysis].
Review
Kurokawa, Sendai, Japan. In Nihon Eiseigaku Zasshi, 2011
The beta3 adrenergic receptor (ADRB3) is a part of the adrenergic system, which is known to play a key role in energy metabolism.
Structure and function of the beta 3-adrenergic receptor.
Review
Impact
Strosberg, Paris, France. In Annu Rev Pharmacol Toxicol, 1996
Recently, the incidence of a naturally occurring variant of the human beta 3-adrenergic receptor was shown to be correlated with hereditary obesity in Pima Indians and in Japanese individuals, and in Western obese patients with increased dynamic capacity to add on weight and develop non-insulin-dependent diabetes mellitus (NIDDM).
Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns.
Impact
Groop et al., Lund, Sweden. In N Engl J Med, 1995
BACKGROUND: Because visceral obesity predicts insulin resistance, we studied whether alterations in the gene encoding for the beta 3-adrenergic receptor in visceral fat are associated with insulin resistance.
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.
Impact
Strosberg et al., Lille, France. In N Engl J Med, 1995
BACKGROUND: The beta 3-adrenergic receptor, located mainly in adipose tissue, is involved in the regulation of lipolysis and thermogenesis.
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