Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generationmore suppliers
In Brain and Behavior, 2010
... ), mouse monoclonal anti-BACE1 ectodomain antibody (MAB9311, R&D Systems, Minneapolis, MN), and rabbit polyclonal anti-BACE1 C-terminal antibodies (M-83, Santa Cruz Biotechnology, Santa Cruz, CA; AB5832, ...
A Non-Canonical Role for β-Secretase in the Retina.
Indianapolis, United States. In Adv Exp Med Biol, Dec 2015
It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized.
η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
München, Germany. In Nature, Nov 2015
We identify higher molecular mass carboxy-terminal fragments (CTFs) of APP, termed CTF-η, in addition to the long-known CTF-α and CTF-β fragments generated by the α- and β-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (β-site APP cleaving enzyme 1), respectively.
Targeting the β secretase BACE1 for Alzheimer's disease therapy.
More papers using
Cleveland, United States. In Lancet Neurol, 2014
The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the toxic amyloid β (Aβ) that plays a crucial early part in Alzheimer's disease pathogenesis.