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Beta-site APP-cleaving enzyme 1

beta-secretase, BACE1, BACE
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: APP, CAN, V1a, AGE, Presenilin-1
Papers using beta-secretase antibodies
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
Araki Wataru et al., In Brain and Behavior, 2010
... ), mouse monoclonal anti-BACE1 ectodomain antibody (MAB9311, R&D Systems, Minneapolis, MN), and rabbit polyclonal anti-BACE1 C-terminal antibodies (M-83, Santa Cruz Biotechnology, Santa Cruz, CA; AB5832, ...
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
Smith Mark A., In PLoS ONE, 2009
... Additional BACE1 antibodies Ab2077 (Abcam, Cambridge MA); sc-73729 and ...
The mouse brain in stereotaxic coordinates.
Combs Colin, In PLoS ONE, 2007
... The resultant F1 heterozygous BACE1 knockout mice and hemizygous 5XFAD transgenic mice were further intercrossed, ...
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC).
Iijima Koichi M., In PLoS ONE, 2005
... were used: α-Cyano-4-hydroxy-cinnamic acid, anti-FLAG M2 and anti-HA affinity gel from Sigma-Aldrich, metalloprotease inhibitor TAPI-1, BACE inhibitor C3, γ-secretase inhibitor X (referred to as Merck A) ...
Functionalization and peptide-based delivery of magnetic nanoparticles as an intracellular MRI contrast agent
Li Feng et al., In Molecular therapy. Nucleic acids, 2003
... Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model ...
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Papers on beta-secretase
Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion.
Liu et al., Shanghai, China. In Oncol Rep, Feb 2016
The mRNA expression levels of long non-coding RNA (lncRNA) β-site APP cleaving enzyme 1 antisense strand (BACE1-AS) were significantly increased in anisomycin-treated OCSCs compared to controls.
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from corydalis cava (fumariaceae) as Alzheimer's disease targets.
Andrisano et al., Hradec Králové, Czech Republic. In Fitoterapia, Feb 2016
Determination of ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibition was carried out using a BACE1-Immobilized Enzyme Reactor (IMER) by validating the assay with a multi-well plate format Fluorescence Resonance Energy Transfer (FRET) assay.
Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.
Jeon et al., South Korea. In Mol Neurobiol, Feb 2016
As a downstream effector of AMPK, beta-secretase expression was decreased by clozapine administration.
A Non-Canonical Role for β-Secretase in the Retina.
Boulton et al., Indianapolis, United States. In Adv Exp Med Biol, Dec 2015
It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized.
η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Haass et al., München, Germany. In Nature, Nov 2015
We identify higher molecular mass carboxy-terminal fragments (CTFs) of APP, termed CTF-η, in addition to the long-known CTF-α and CTF-β fragments generated by the α- and β-secretases ADAM10 (a disintegrin and metalloproteinase 10) and BACE1 (β-site APP cleaving enzyme 1), respectively.
Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.
Yan et al., Cleveland, United States. In J Neurochem, Nov 2015
UNASSIGNED: Inhibition of BACE1 is being pursued as a therapeutic target to treat patients suffering from Alzheimer's disease because BACE1 is the sole β-secretase that generates β-amyloid peptide.
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Cardona-Gómez et al., Medellín, Colombia. In Front Cell Neurosci, 2014
β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer's disease (AD).
The Role of Oxidative Stress-Induced Epigenetic Alterations in Amyloid-β Production in Alzheimer's Disease.
Best et al., Columbus, United States. In Oxid Med Cell Longev, 2014
Analyzing the ROS response of essential proteins in the amyloidogenic pathway, such as amyloid-beta precursor protein (APP) and beta-secretase (BACE1), along with influential signaling programs of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Jun N-terminal kinase (JNK), has helped visualize the path between OS and Aβ overproduction.
Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease.
Majsterek et al., Łódź, Poland. In Curr Med Chem, 2014
That attenuates general translation and, on the other hand, promotes the preferential synthesis of Activating Transcription Factor 4 (ATF4) and secretase β (BACE1) - a pivotal enzyme responsible for the initiation of the amyloidogenic pathway resulting in the generation of the amyloid β (Aβ) variant with high ability to form toxic senile plaques in AD brains.
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.
Mozrzymas et al., Wrocław, Poland. In Front Cell Neurosci, 2014
A growing body of evidence demonstrates that among perisynaptic proteases, tissue plasminogen activator (tPA)/plasmin system, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and metalloproteinases play a crucial role in shaping plastic changes in this projection.
Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.
Maple-Grødem et al., Stavanger, Norway. In Parkinsons Dis, 2014
The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study.
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.
Osswald et al., West Lafayette, United States. In Chem Soc Rev, 2014
BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease.
Targeting the β secretase BACE1 for Alzheimer's disease therapy.
Vassar et al., Cleveland, United States. In Lancet Neurol, 2014
The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the toxic amyloid β (Aβ) that plays a crucial early part in Alzheimer's disease pathogenesis.
Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.
Liao et al., Memphis, United States. In Cell Metab, 2013
We found increased transcription of β-secretase/BACE1, the rate-limiting enzyme for Aβ generation, in eNOS-deficient mouse brains and after feeding mice a high-fat, high-cholesterol diet.
MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1.
Duan et al., Zhengzhou, China. In Brain Res Bull, 2012
Overexpression of miR-195 in N2a/WT cells decreased the BACE1 protein level, and inhibition of miR-195 resulted in increase of BACE1 protein level.
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
De Strooper et al., Leuven, Belgium. In J Biol Chem, 2012
L1 and CHL1 are cleaved by BACE1 under physiological conditions
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
Lichtenthaler et al., München, Germany. In Embo J, 2012
The new substrates point to a central function of BACE1 in neurite outgrowth and synapse formation.
Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.
Bonifacino et al., Bethesda, United States. In Mol Biol Cell, 2012
Data show that cleavage of amyloid precursor protein (APP) by beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) occurs in post-endoplasmic reticulum (ER) compartments.
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.
Tan et al., Tampa, United States. In Nat Commun, 2011
Soluble amyloid precursor protein-alpha modulates BACE1 activity and amyloid-beta generation.
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
Worley et al., Baltimore, United States. In Cell, 2011
Assemblies of β-amyloid (Aβ) peptides are pathological mediators of Alzheimer's Disease (AD) and are produced by the sequential cleavages of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase.
More papers using beta-secretase antibodies
Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms.
Okazawa Hitoshi, In PLoS ONE, 1991
... (1∶500), rabbit anti-APP (1∶15000, Sigma-Aldrich), mouse anti-APP (1 µg/ml, Millipore), rabbit-anti BACE (1∶2000, Merck, Darmstadt, Germany) mouse anti-PS1 ...
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