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Glucuronidase, beta

beta-glucuronidase
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, V1a
Papers using beta-glucuronidase antibodies
Cathepsin K predicts femoral neck bone mineral density change in nonosteoporotic peri- and early postmenopausal women
Supplier
Ostanek Barbara et al., In Journal of Translational Medicine, 2007
... Cell culture reagents, beta-glucuronidase from Helix pomatia, E-3-S, raloxifene hydrochloride and haloperidol were from Sigma Aldrich Chemie (Deisenhofen, Germany) ...
Papers on beta-glucuronidase
Wheat TaSP gene improves salt tolerance in transgenic Arabidopsis thaliana.
New
Huang et al., Shijiazhuang, China. In Plant Physiol Biochem, Dec 2015
TaSP promoter was cloned, and its beta-glucuronidase (GUS) activities before and after ABA, salt, cold, heat, and salicylic acid (SA) stresses were determined.
Expression profiles of somatostatin, dopamine, and estrogen receptors in pituitary adenomas determined by means of synthetic multilocus calibrators.
New
Cap et al., Hradec Králové, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, Dec 2015
The obtained data were normalized to the number of transcripts of the beta-glucuronidase gene.
Effects of epidermal growth factor receptor inhibitor on proliferative cholangitis in hepatolithiasis.
New
Zhang et al., Chengdu, China. In Hepatobiliary Pancreat Dis Int, Oct 2015
Gefitinib treatment significantly decreased mucin 3 expression and beta-glucuronidase activity.
Characterization of FeDREB1 promoter involved in cold- and drought-inducible expression from common buckwheat (Fagopyrum esculentum).
Feng et al., China. In Genet Mol Res, 2014
Promoter-beta-glucuronidase fusion assays revealed that the pCD1 (-270 bp) deletion in the upstream region of FeDREB1 could activate expression of the GUS gene at 4°C.
Two short sequences in OsNAR2.1 promoter are necessary for fully activating the nitrate induced gene expression in rice roots.
Xu et al., Key West, United States. In Sci Rep, 2014
To identify the cis-acting DNA elements necessary for nitrate induced gene expression, we detected the expression of beta-glucuronidase (GUS) reporter in the transgenic rice driven by the OsNAR2.1 promoter with different lengths and site mutations of the 311 bp region.
Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity.
Review
Fildes et al., Manchester, United Kingdom. In J Inherit Metab Dis, 2014
Mucopolysaccharidosis I (MPS I), MPS IIIA, MPS IIIB and MPS VII are deficient in the enzymes α-L-Iduronidase, Heparan-N-Sulphatase, N-Acetylglucosaminidase and Beta-Glucuronidase, respectively.
Expression of common housekeeping genes is affected by disease in human hepatitis C virus-infected liver.
GeneRIF
Desmond et al., Melbourne, Australia. In Liver Int, 2011
Liver disease affects the expression of common HKGs; beta-glucuronidase and splicing factor arginine/serine-rich 4 are the most stable HKGs for studies of gene expression in HCV-infected human liver.
GhMPK7, a novel multiple stress-responsive cotton group C MAPK gene, has a role in broad spectrum disease resistance and plant development.
Review
Guo et al., Tai'an, China. In Plant Mol Biol, 2010
beta-glucuronidase activity driven by the GhMPK7 promoter was detected in the apical meristem at the vegetative stage, and it was enhanced by treatments with signal molecules and phytohormones.
Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives.
Review
Srinivas, Bengaluru, India. In Xenobiotica, 2010
The absorption of baicalin involved several complexities: the restriction to two distant sites; the conversion of baicalin to baicalein; the possible role of transporter(s); and enhanced absorption due to breakdown of conjugates by beta-glucuronidase.
Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
GeneRIF
Lasko et al., Montréal, Canada. In Mol Cell Biol, 2010
Data suggest that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.
New strategies for enzyme replacement therapy for lysosomal storage diseases.
Review
Sly et al., Saint Louis, United States. In Rejuvenation Res, 2010
First, we used a chimeric protein of the insulin-like growth factor II (IGF-II) fused to beta-glucuronidase to deliver enzyme via the IGF-II binding site on the bifunctional IGF-II/mannose 6-phosphate receptor.
Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.
GeneRIF
Lass et al., Graz, Austria. In J Lipid Res, 2009
The Gus plays a role in liver retinoid metabolism.
Juxtapapillary duodenal diverticula and pancreatobiliary disease.
Review
Kamisawa et al., Tokyo, Japan. In Dig Surg, 2009
They are considered to lead to bile stasis and to allow reflux from the duodenum into the bile duct, which results in an ascending infection of beta-glucuronidase-producing bacteria.
Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome).
Review
GeneRIF
Sly et al., Saint Louis, United States. In Hum Mutat, 2009
Study summarized information on the 49 unique, disease-causing mutations determined so far in the GUS gene.
Purification, cloning and functional characterization of an endogenous beta-glucuronidase in Arabidopsis thaliana.
GeneRIF
Jouanin et al., Versailles, France. In Plant Cell Physiol, 2008
AtGUS2 modifies glucuronic acid content in the polysaccharidic side chains of arabinogalactan proteins.
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
Impact
Hoenderop et al., Nijmegen, Netherlands. In Science, 2005
Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane.
Enzyme-catalyzed activation of anticancer prodrugs.
Review
Impact
Vermeulen et al., Amsterdam, Netherlands. In Pharmacol Rev, 2004
The following endogenous enzymes are discussed: aldehyde oxidase, amino acid oxidase, cytochrome P450 reductase, DT-diaphorase, cytochrome P450, tyrosinase, thymidylate synthase, thymidine phosphorylase, glutathione S-transferase, deoxycytidine kinase, carboxylesterase, alkaline phosphatase, beta-glucuronidase and cysteine conjugate beta-lyase.
Mutant enzymatic and cytological phenotypes in cultured human fibroblasts.
Impact
Demars et al., In Science, 1967
The fibroblasts differ from those of controls and of patients with typical Hurler syndrome or other mucopolysaccharidoses in that they have abundant cytoplasmic inclusions, striking diminutions in beta-glucuronidase, and elevations in acid phosphatase.
Beta-glucuronidase activity in serum increased by coronary-artery atherosclerosis.
Impact
Curreri et al., In Science, 1966
Increase in activity of beta-glucuronidase in serum has been demonstrated in patients having clinically evident coronary-artery atherosclerosis.
Glucuronidase activation: enzyme action at an interface.
Impact
MAVRIDES et al., In Science, 1960
The potentiating action of chloroform on bacterial beta-glucuronidase has been shown to increase as the interface area between the two liquid phases increases.
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