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Sodium channel, nonvoltage-gated 1, beta

beta-ENaC, SCNN1B
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009] (from NCBI)
Papers on beta-ENaC
Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced βENaC expression.
Drummond et al., Jackson, United States. In Am J Physiol Renal Physiol, 2012
These findings demonstrate that myogenic constriction in afferent arterioles is dependent on normal expression of betaENaC
Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1.
Wilson et al., Dundee, United Kingdom. In Br J Pharmacol, 2012
investigation of control of airway epithelial Na+ absorption via up-regulation/phosphorylation of ENaCalpha, ENaCbeta, and ENaCgamma involving SGK1 (serum-glucocorticoid regulated kinase 1) under control of glucocorticoid/dexamethasone
Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.
Hanukoglu et al., Jerusalem, Israel. In Histochem Cell Biol, 2012
ENaC on motile cilia should be essential for diverse functions of motile cilia, such as germ cell transport, fertilization, implantation, clearance of respiratory airways and cell migration.
Effects of rhinovirus infection on the expression and function of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel in human nasal mucosa.
Jang et al., Ch'unch'ŏn, South Korea. In Ann Allergy Asthma Immunol, 2012
study found that rhinovirus (RV) infection of primary human nasal epithelial cells enhanced the expression of CFTR, alpha-ENaC, beta-ENaC, and gamma-ENaC mRNA and protein; upregulated CFTR might be dysfunctional, whereas RV-upregulated ENaC was hyperfunctional
Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.
Armstrong et al., Baton Rouge, United States. In Am J Physiol Endocrinol Metab, 2012
Data indicate that functional ENaC (subunits Scnn1a, Scnn1b, and Scnn1g) may affect firing patterns of magnocellular cells (i.e., large neurons) in supraoptic nucleus and paraventricular nucleus and thus control secretion of vasopressin and oxytocin.
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