Treatment of acromegaly in the era of personalized and predictive medicine.
Badalona, Spain. In Clin Endocrinol (oxf), Jul 2015
This review will discuss the development of a potential treatment algorithm for acromegaly addressing the biochemical control of the disease as well of its associated comorbidities, under a personalized approach based upon markers of prognostic and predictive significance, such as tumour size, MRI adenoma signal, GH value after acute octreotide test, granular adenoma pattern, Ki-67, somatostatin receptor phenotype, aryl hydrocarbon-interacting protein expression, gsp mutations, RAF kinase activity, E-cadherin and beta-arrestin-1.
Activated protein C: biased for translation.
Los Angeles, United States. In Blood, Jun 2015
For these beneficial effects, APC alters cell signaling networks and gene expression profiles by activating protease-activated receptors 1 and 3. APC's activation of these G protein-coupled receptors differs completely from thrombin's activation mechanism due to biased signaling via either G proteins or β-arrestin-2.
Molecular Physiology of Enteric Opioid Receptors.
Lansing, United States. In Am J Gastroenterol, 2014
This may be due to differential β-arrestin-2-dependent opioid receptor desensitization and internalization in enteric nerves in the colon compared with the small intestine and in neuronal pain pathways.
Omega-3 Fatty Acids and FFAR4.
San Diego, United States. In Front Endocrinol (lausanne), 2013
This makes FFAR4 to be capable of interacting with β-arrestin-2, which in turn, results in association of β-arrestin-2 with TAB1.
Insulin action under arrestin.
Australia. In Cell Metab, 2009
In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating assembly of a complex containing insulin receptor, c-Src, and Akt.