Drug Design targeting the CXCR4/CXCR7/CXCL12 pathway.
Omaha, United States. In Curr Top Med Chem, Oct 2015
The function of CXCR7 is generally considered to be mediated by: (a) recruiting β-arrestin-2; (b) heterodimerizing with CXCR4; and (c) acting as a "scavenger" of CXCL12, thus lowering the level of CXCL12 to weaken the activity of CXCR4.
Treatment of acromegaly in the era of personalized and predictive medicine.
Badalona, Spain. In Clin Endocrinol (oxf), Jul 2015
This review will discuss the development of a potential treatment algorithm for acromegaly addressing the biochemical control of the disease as well of its associated comorbidities, under a personalized approach based upon markers of prognostic and predictive significance, such as tumour size, MRI adenoma signal, GH value after acute octreotide test, granular adenoma pattern, Ki-67, somatostatin receptor phenotype, aryl hydrocarbon-interacting protein expression, gsp mutations, RAF kinase activity, E-cadherin and beta-arrestin-1.
Activated protein C: biased for translation.
Los Angeles, United States. In Blood, Jun 2015
For these beneficial effects, APC alters cell signaling networks and gene expression profiles by activating protease-activated receptors 1 and 3. APC's activation of these G protein-coupled receptors differs completely from thrombin's activation mechanism due to biased signaling via either G proteins or β-arrestin-2.
Molecular Physiology of Enteric Opioid Receptors.
Lansing, United States. In Am J Gastroenterol, 2014
This may be due to differential β-arrestin-2-dependent opioid receptor desensitization and internalization in enteric nerves in the colon compared with the small intestine and in neuronal pain pathways.
Insulin action under arrestin.
Australia. In Cell Metab, 2009
In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating assembly of a complex containing insulin receptor, c-Src, and Akt.