beta-Adrenoceptor inverse agonists in asthma.
Houston, United States. In Curr Opin Pharmacol, 2010
The data suggest that beta(2)-AR signaling is required to produce maximal airway inflammation and hyperresponsiveness, and the signaling pathway responsible for these effects is likely the non-canonical beta-arrestin-2 pathway.
Validating GSK3 as an in vivo target of lithium action.
Philadelphia, United States. In Biochem Soc Trans, 2009
However, lithium also inhibits inositol monophosphatase, several structurally related phosphomonoesterases, phosphoglucomutase and the scaffolding function of beta-arrestin-2.
Insulin action under arrestin.
Australia. In Cell Metab, 2009
In mouse models, beta-arrestin-2 controls whole-body insulin action by regulating assembly of a complex containing insulin receptor, c-Src, and Akt.
Physiologic and cardiac roles of beta-arrestins.
Durham, United States. In J Mol Cell Cardiol, 2009
Beta-arrestin1 and beta-arrestin2 were initially identified by sequence homology to visual arrestins and by their ability to bind to and inactivate signaling of the beta-2-adrenergic receptor in a process known as desensitization.
Akt/GSK3 signaling in the action of psychotropic drugs.
Québec, Canada. In Annu Rev Pharmacol Toxicol, 2008
Furthermore, investigations of the mechanism by which D2 dopamine receptors regulate Akt/GSK3 signaling strongly support the physiological relevance of a new modality of G protein-coupled receptor (GPCR) signaling involving the multifunctional scaffolding protein beta-arrestin 2. Elucidation of the contribution of multiple signaling pathways to the action of psychotropic drugs may provide a better biological understanding of psychiatric disorders and lead to more efficient therapeutics.
Looking at lithium: molecular moods and complex behaviour.
Québec, Canada. In Mol Interv, 2008
We also highlight recent findings suggesting that lithium could exert some of its behavioral effects by acting on a dopamine receptor regulated signaling complex composed of Akt, protein phosphatase 2A, and the multifunctional protein scaffold beta-arrestin 2.