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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Adrenergic, beta-2-, receptor, surface

beta 2-adrenoceptor, beta2-adrenergic receptor, FXR, farnesoid X receptor, BAR
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, Actin
Papers using beta 2-adrenoceptor antibodies
Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis
Supplier
Lobaccaro Jean-Marc A., In PLoS ONE, 2009
... The VP-FXR transgenic mice were generated as ...
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.
Supplier
Moschetta Antonio, In PLoS ONE, 2007
... The VP-FXR transgenic mice were created by ...
The impact of cigarette smoking on periodontal disease and treatment.
Supplier
II Roy Martin Roop, In PLoS ONE, 2006
... BAR peptide was synthesized by Biosynthesis Inc ...
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Supplier
Appanna Vasu D., In PLoS ONE, 1999
... Cayman Chemical) for LXRα, calcipotriol (10 µM; Sigma) for VDR, GW4064 (1 µM; Sigma) for FXR, WY14643 (30 µM; Sigma) for PPARα, GW501516 (100 nM) for PPARδ, rosiglitazone (1 µM; Cayman Chemical) for PPARγ, dexamethasone ...
Papers on beta 2-adrenoceptor
Type 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery.
New
Han et al., Nanjing, China. In Metabolism, Feb 2016
Bile acids can bind to and activate the nuclear receptor farnesoid-X receptor (FXR) by regulating lipid and glucose metabolism.
The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis.
New
Gould et al., Nashville, United States. In Cell Rep, Feb 2016
UNASSIGNED: F-BAR proteins link cellular membranes to the actin cytoskeleton in many biological processes.
Role of PPARα in the Attenuation of Bile Acid-Induced Apoptosis by Omega-3 Long-Chain Polyunsaturated Fatty Acids in Cultured Hepatocytes.
New
Black et al., Memphis, United States. In Pediatr Res, Feb 2016
Activation of PPARα was evaluated, and expression of PPARα, farnesoid X receptor (FXR), liver X receptor alpha (LXRα), and retinoid X receptor (RXR) mRNA was evaluated by RT-PCR.
Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model.
New
Zeng et al., Wuhan, China. In Mol Med Report, Feb 2016
UNASSIGNED: Farnesoid X receptor (FXR) is an important regulator of glucose and lipid homeostasis.
Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health.
Review
New
Gahan et al., Cork, Ireland. In Annu Rev Food Sci Technol, Feb 2016
UNASSIGNED: Bile acids have emerged as important signaling molecules in the host, as they interact either locally or systemically with specific cellular receptors, in particular the farnesoidXreceptor (FXR) and TGR5.
The role of bile acids in the metabolic regulations.
Review
New
Haluzik et al., Praha, Czech Republic. In J Endocrinol, Feb 2016
BA affect multiple functions to control energy homeostasis, as well as glucose and lipid metabolism, predominantly by activating the nuclear farnesoid X receptor (FXR), and cytoplasmic G protein-coupled BA receptor TGR5 in a variety of tissues.
Management of non-alcoholic fatty liver disease in 2015.
Review
New
Beaton et al., London, Canada. In World J Hepatol, Jan 2016
The study of anti-fibrotic agents such as pentoxifylline and FXR agonists hold promise and new pathways, such as hepatocyte cannabinoid receptor antagonists are being studied.
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.
Review
New
Li et al., East Lansing, United States. In Pharmacol Res, Jan 2016
Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body.
Bile acid receptors and nonalcoholic fatty liver disease.
Review
New
Bambha et al., Los Angeles, United States. In World J Hepatol, Jan 2016
Recent advances in the functional characterization of bile acid receptors, such as farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor (TGR) 5, have provided further insight in the pathophysiology of NASH and have led to the development of potential therapeutic targets for NAFLD and NASH.
Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor.
New
Van de Graaf et al., Eindhoven, Netherlands. In J Vis Exp, Dec 2015
Here, we describe the application of a genetically encoded Bile Acid Sensor (BAS) that consists of two fluorophores fused to the farnesoid X receptor ligand binding domain (FXR-LBD), thereby forming a bile acid sensor that can be activated by a large number of bile acids species and other (synthetic) FXR ligands.
Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry.
New
Impact
Mangelsdorf et al., Dallas, United States. In Cell Metab, Jul 2015
Using this assay, we show that FGF15 circulates in plasma in an FXR and circadian rhythm-dependent manner at concentrations that activate its receptor.
The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.
Review
New
Impact
Sandoval et al., Ann Arbor, United States. In Cell Metab, Apr 2015
Moreover, loss of function of the nuclear bile acid receptor (FXR) greatly diminishes the effects of VSG.
A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice.
New
Impact
Cao et al., Bethesda, United States. In Cell Metab, Apr 2015
We further demonstrate that the regulation of apoC2 expression occurs through an FXR-mediated pathway.
MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
New
Impact
Edwards et al., Los Angeles, United States. In Cell Metab, Mar 2015
Bile acids are synthesized from cholesterol in the liver, and the key enzymes involved in bile acid synthesis (Cyp7a1, Cyp8b1) are regulated transcriptionally by the nuclear receptor FXR.
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
New
Impact
Evans et al., Los Angeles, United States. In Nat Med, Feb 2015
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis.
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
GeneRIF
Liggett et al., Baltimore, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization.
High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy.
GeneRIF
Harding et al., London, United Kingdom. In Circulation, 2012
Epinephrine-specific beta2AR-Gi signaling may have evolved as a cardioprotective strategy to limit catecholamine-induced myocardial toxicity during acute stress.
β2-adrenergic receptor haplotype linked to intubation and mechanical ventilation in children with asthma.
GeneRIF
Schramm et al., Hartford, United States. In J Asthma, 2012
Children with the Arg16Gly-Gln27Gln haplotype of the ADRbeta(2) were four times more likely to be intubated and mechanically ventilated during severe asthma exacerbations
Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.
GeneRIF
Hillgartner et al., Morgantown, United States. In J Biol Chem, 2012
the enhanced enterohepatic flux of bile acids during HF-LC consumption leads to activation of hepatic FXR and FGF19 signaling activity and an increase in FGF21 gene expression and secretion.
Rab1 interacts directly with the β2-adrenergic receptor to regulate receptor anterograde trafficking.
GeneRIF
Dupré et al., Halifax, Canada. In Biol Chem, 2012
the potential interaction of Rab1 and its effect on export from the endoplasmic reticulum
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