The role of bile acids in the metabolic regulations.
Praha, Czech Republic. In J Endocrinol, Feb 2016
BA affect multiple functions to control energy homeostasis, as well as glucose and lipid metabolism, predominantly by activating the nuclear farnesoid X receptor (FXR), and cytoplasmic G protein-coupled BA receptor TGR5 in a variety of tissues.
Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.
East Lansing, United States. In Pharmacol Res, Jan 2016
Ultimately, seminal studies by many investigators led to the discovery of several bile acid-activated receptors including the farnesoid X receptor, the vitamin D receptor, the pregnane X receptor, TGR5, α5 β1 integrin, and sphingosine-1-phosphate receptor 2. Several of these receptors are expressed outside of the gastrointestinal system, indicating that bile acids may have diverse functions throughout the body.