beta 1-adrenergic receptor
Modeling beta-adrenergic control of cardiac myocyte contractility in silico.
San Diego, United States. In J Biol Chem, 2003
3-Fold overexpression of adenylyl cyclase in the model allowed an 85% higher rate of cyclic AMP synthesis than an equivalent overexpression of beta 1-adrenergic receptor, and manipulating the affinity of Gs alpha for adenylyl cyclase was a more potent regulator of cyclic AMP production.
Beta-adrenergic receptors in failing human myocardium.
Halle, Germany. In Basic Res Cardiol, 1995
In the failing human myocardium beta 1-adrenergic receptor number is decreased, and this is accompanied by a reduced beta 1-adrenergic receptor mediated positive inotropic effect.
Is the senescent heart overloaded and already failing?
Paris, France. In Cardiovasc Drugs Ther, 1994
Changes in specific mRNAs include: a shift in myosin heavy chain (MHC) isogene expression leading to an increased beta MHC content; decreased densities of Ca2+ ATPase of the sarcoplasmic reticulum, beta 1-adrenergic receptor, and muscarinic receptors; and attenuation of the Na+/Ca2+ exchange activity.
Neurologic consequences of hypertension and antihypertensive drug therapy.
Birmingham, United States. In Curr Opin Nephrol Hypertens, 1994
As a class, the angiotensin-converting enzyme inhibitors most consistently lead to cognitive improvement in the overall hypertensive population, but beta 1-adrenergic receptor blockers and a subset of calcium channel blockers appear to have very similar effects.