Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.
Saint Louis, United States. In Cell Host Microbe, Feb 2016
Using a lysozyme-M-cre (LysMcre) expression system, we show that deletion of autophagy-related (Atg) genes Fip200, beclin 1, Atg14, Atg16l1, Atg7, Atg3, and Atg5, in the myeloid compartment, inhibited MHV68 reactivation in macrophages.
FGF signalling regulates bone growth through autophagy.
Pozzuoli, Italy. In Nature, Jan 2016
Surprisingly, post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1.
Redox regulation of autophagy in healthy brain and neurodegeneration.
Toledo, United States. In Neurobiol Dis, Dec 2015
To exemplify one such novel therapeutic entity, data is presented that the antioxidant and neurotrophic agent lanthionine ketimine-ethyl ester (LKE) affects autophagy pathway proteins including beclin-1 in the 3xTg-AD model of Alzheimer's disease where the compound has been shown to reduce pathological features and cognitive dysfunction.
Regulation of autophagy by beclin 1 in the heart.
Newark, United States. In J Mol Cell Cardiol, Dec 2015
Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the autophagy machinery, plays a central role in the regulation of autophagy through activation of Vps34.
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Stanford, United States. In Nature, May 2015
Here we report that ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the class III phosphatidylinositol 3-kinase complex, promotes membrane tethering of protein-free liposomes, and enhances hemifusion and full fusion of proteoliposomes reconstituted with the target (t)-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) syntaxin 17 (STX17) and SNAP29, and the vesicle (v)-SNARE VAMP8 (vesicle-associated membrane protein 8).
AMBRA1-regulated autophagy in vertebrate development.
More papers using
Roma, Italy. In Int J Dev Biol, 2014
In this review, we discuss the role of upstream regulators of autophagy in the development of different model systems, focusing, in particular, on AMBRA1 (autophagy/beclin-1 regulator-1) and its role in the central nervous system.
Aging: past, present and future
In Cell Cycle, 2008
... Commercially available antibodies used were as follows: β-actin (Sigma-Aldrich, #A5441); Cav-1 (BD Transduction Laboratories, #610406); Beclin1 (Novus Biologicals, #NBP1–00085); BNIP3 (Abcam, #ab10433); ... Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
In PLoS ONE, 2007
... Rabbit anti-human cleaved caspase-9, -7, -3, poly ADP-ribose polymerase (PARP), rabbit anti-human, PUMA, Bcl-2, Beclin-1, Atg-5, Atg-12 were purchased from Cell Signaling (Canada) ... Calpain: a role in cell transformation and migration
In PLoS ONE, 2001
... ERK1/2 (Thr202/Tyr204), MAPAPK2 (Thr222), p38 (Thr180/Tyr182), mTOR (Ser2448), PKB, phospho-PDK1 (Ser241), phospho-GSK3β (Ser9), LC3B and Beclin1, were purchased from Cell Signaling Technology (Beverly, MA) ...