GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Beclin 1, autophagy related
Beclin 1, Atg6
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010] (from
NCBI)
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Top mentioned proteins:
LC3, PrP, CAN, V1a, Atg5
Papers using
Beclin 1
antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Supplier
In Cell Cycle, 2010
... antibodies used were as follows: β-actin (Sigma-Aldrich, #A5441); Cav-1 mAb 2297 (BD Transduction Laboratories, #610406); Beclin1 (Novus Biologicals, #NBP1-00085); BNIP3 (Abcam, #ab10433); ...
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
Supplier
In Cell Cycle, 2010
... commercial sources: Anti-DRAM [# sc-98654 (H-128); Santa Cruz Biotech], anti-Cav-1 [#sc-894 (N-20); Santa Cruz Biotech], anti-Beclin1 (for immuno-blot #NBP1–00085, Novus; for immunostaining #2026–1, Epitomics), anti-LAMP1 [#sc-17768 (E-5); Santa ...
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1
Supplier
In Experimental Diabetes Research, 2010
... Antibodies for TXNIP and beclin 1 were obtained from MBL (Woburn, MA) ...
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Supplier
In The Journal of Cell Biology, 2009
... The antibodies to ATG5 and Beclin1 were purchased from Novus Biologicals.
Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.
more suppliersSupplier
In PLoS ONE, 2009
... [Danvers, MA]; anti-Beclin 1 CAT# NBP1-45382 from Novus Biologicals, LLC [Littleton, CO]; anti-beta ...
Papers on
Beclin 1
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade.
New
Baltimore, United States. In Proc Natl Acad Sci U S A, Feb 2016
Depletion of ATG5 or beclin-1, major mediators of autophagy, prevents cocaine-induced cell death.
Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.
New
Saint Louis, United States. In Cell Host Microbe, Feb 2016
Using a lysozyme-M-cre (LysMcre) expression system, we show that deletion of autophagy-related (Atg) genes Fip200, beclin 1, Atg14, Atg16l1, Atg7, Atg3, and Atg5, in the myeloid compartment, inhibited MHV68 reactivation in macrophages.
Reactive Oxygen Species-Initiated Autophagy Opposes Aldosterone-Induced Podocyte Injury.
New
Nanjing, China. In Am J Physiol Renal Physiol, Feb 2016
Autophagy was evaluated by measuring the expressions of LC3, p62, beclin-1 and Atg5.
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.
New
Boston, United States. In Cell Rep, Feb 2016
HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to controls.
FGF signalling regulates bone growth through autophagy.
New
Impact
Pozzuoli, Italy. In Nature, Jan 2016
Surprisingly, post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1.
Redox regulation of autophagy in healthy brain and neurodegeneration.
Review
New
Toledo, United States. In Neurobiol Dis, Dec 2015
To exemplify one such novel therapeutic entity, data is presented that the antioxidant and neurotrophic agent lanthionine ketimine-ethyl ester (LKE) affects autophagy pathway proteins including beclin-1 in the 3xTg-AD model of Alzheimer's disease where the compound has been shown to reduce pathological features and cognitive dysfunction.
Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis.
New
Guangzhou, China. In Plos One, Dec 2015
The induction of autophagy was supported by the accumulation of acidic vesicular organelles and autolysosomes, and the expression of autophagy-associated proteins, including microtubule-associated protein II light chain 3 (LC3-II), beclin-1, and autophagocytosis-associated protein (Atg)3.
Autophagy in colorectal cancer: An important switch from physiology to pathology.
Review
New
Craiova, Romania. In World J Gastrointest Oncol, Dec 2015
Autophagy studies in CRC have focused on several molecules, mainly microtubule-associated protein 1 light chain 3, beclin 1, and autophagy related 5, with conflicting results.
Regulation of autophagy by beclin 1 in the heart.
Review
New
Newark, United States. In J Mol Cell Cardiol, Dec 2015
Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the autophagy machinery, plays a central role in the regulation of autophagy through activation of Vps34.
Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis.
Review
New
Nanjing, China. In Exp Cell Res, Nov 2015
Transmission electron microscopy and biochemical autophagic flux assays were used to measure the autophagy markers microtubule-associated protein 1 light chain 3-II (LC3-II) and beclin-1.
ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
New
Impact
Stanford, United States. In Nature, May 2015
Here we report that ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the class III phosphatidylinositol 3-kinase complex, promotes membrane tethering of protein-free liposomes, and enhances hemifusion and full fusion of proteoliposomes reconstituted with the target (t)-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) syntaxin 17 (STX17) and SNAP29, and the vesicle (v)-SNARE VAMP8 (vesicle-associated membrane protein 8).
AMBRA1-regulated autophagy in vertebrate development.
Review
Roma, Italy. In Int J Dev Biol, 2014
In this review, we discuss the role of upstream regulators of autophagy in the development of different model systems, focusing, in particular, on AMBRA1 (autophagy/beclin-1 regulator-1) and its role in the central nervous system.
PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.
Impact
Los Angeles, United States. In Nat Cell Biol, 2013
Here, we identify UVRAG, a beclin-1-binding autophagic factor, as a phosphatidylinositol-3-phosphate (PtdIns(3)P)-binding protein that depends on PtdIns(3)P for its ER localization.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Impact
Leuven, Belgium. In Nat Cell Biol, 2013
Deubiquitylated RALB promotes the assembly of the RALB-EXO84-beclin-1 complexes driving autophagosome formation.
Control of autophagic cell death by caspase-10 in multiple myeloma.
Impact
Bethesda, United States. In Cancer Cell, 2013
Caspase-10 inhibits autophagy by cleaving the BCL2-interacting protein BCLAF1, itself a strong inducer of autophagy that acts by displacing beclin-1 from BCL2.
Bim inhibits autophagy by recruiting Beclin 1 to microtubules.
GeneRIF
Cambridge, United Kingdom. In Mol Cell, 2012
Bim inhibits autophagy by interacting with Beclin 1, an autophagy regulator, an interaction facilitated by LC8.
Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling.
GeneRIF
Saint Louis, United States. In J Virol, 2012
Together, these results suggested that hepatitis C virus induces autophagy by upregulating Beclin1 and activates mTOR signaling pathway, which in turn may promote hepatocyte growth.
Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury.
GeneRIF
Saint Louis, United States. In Circulation, 2012
Ischemia/reperfusion injury impairs autophagosome clearance mediated in part by reactive oxygen species-induced decline in lysosome-associated membrane protein-2 and upregulation of BECLIN-1, contributing to increased cardiomyocyte death.
Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma.
GeneRIF
New Delhi, India. In Biochem Biophys Res Commun, 2012
these results demonstrate that down-regulation of Beclin-1 may play an important role in the development and progression of oral cancer possibly by dysregulation of autophagy in tumor cells.
The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.
More papers using
Beclin 1
antibodies
GeneRIF
Suzhou, China. In Acta Pharmacol Sin, 2012
Beclin1 regulates the accumulation of Htt via macroautophagy.
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.
Supplier
In PLoS ONE, 2009
... Lck-Casp9DN mice were backcrossed onto a C57BL/6 background and crossed to Lck-Bax38/1 transgenic or Beclin 1 +/- mice for tumor development studies.Transgenic Lck-Bax mice were previously ...
Aging: past, present and future
Supplier
In Cell Cycle, 2008
... Commercially available antibodies used were as follows: β-actin (Sigma-Aldrich, #A5441); Cav-1 (BD Transduction Laboratories, #610406); Beclin1 (Novus Biologicals, #NBP1–00085); BNIP3 (Abcam, #ab10433); ...
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
Supplier
In Cell Death & Disease, 2007
... TSC2 and ATG6 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
Supplier
In PLoS ONE, 2007
... Rabbit anti-human cleaved caspase-9, -7, -3, poly ADP-ribose polymerase (PARP), rabbit anti-human, PUMA, Bcl-2, Beclin-1, Atg-5, Atg-12 were purchased from Cell Signaling (Canada) ...
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Supplier
In International Journal of Biological Sciences, 2005
... , and anti-Beclin-1 antibodies were obtained from Cell Signaling Technology (Danvers, MA) ...
PHENIX: building new software for automated crystallographic structure
determination
Supplier
In Cell Research, 2001
... localization assay, the Beclin 1 ECD (residues 272-450) was cloned into pEYFP-N1 (Clontech) with a C-terminal YFP ...
Calpain: a role in cell transformation and migration
Supplier
In PLoS ONE, 2001
... ERK1/2 (Thr202/Tyr204), MAPAPK2 (Thr222), p38 (Thr180/Tyr182), mTOR (Ser2448), PKB, phospho-PDK1 (Ser241), phospho-GSK3β (Ser9), LC3B and Beclin1, were purchased from Cell Signaling Technology (Beverly, MA) ...
New colorimetric cytotoxicity assay for anticancer-drug screening
Supplier
In Cell Death and Differentiation, 1989
... The actin, pSMAD3, SMAD3, PP2A, pPP2A and Beclin1 antibodies were from Santa Cruz Biotechnology, Inc ...
