GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Defensin, beta 106A
BD6, beta-defensin 6, mBD-6, DEFB106A, DEFB106
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy. [provided by RefSeq, Jul 2008] (from
NCBI)
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ACID, CAN, HAD, Defensin, fibrillin-1
Papers on
BD6
σ Bond activation through tunneling: formation of the boron hydride cations BHn(+) (n = 2, 4, 6).
New
Athens, United States. In Phys Chem Chem Phys, Feb 2016
After using theoretical results to remove tunneling effects from the experimental rate constants, new Arrhenius fits yield activation barriers of 4.6(3) kcal mol(-1) and 3.8(1) kcal mol(-1) for the BH6(+) and BD6(+) insertion reactions, respectively, which are in near perfect agreement with converged theoretical values (4.6 kcal mol(-1) and 3.9 kcal mol(-1)).
Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung.
New
Ch'ŏnan, South Korea. In Exp Ther Med, Feb 2015
This region contains the following possible target genes, which have previously not been implicated to play a pathogenic role in stage I SCCs: MSRA, MFHAS1, CLDN23, DEFB106A, DEFB105A, LOC441316, FAM90A7P and LOC441318.
Soluble fusion expression, characterization and localization of human β-defensin 6.
Shanghai, China. In Mol Med Report, 2014
Human β‑defensin 6 (DEFB106) is an antimicrobial peptide expressed in the epididymis, testis and lung, which indicates that DEFB106 may be involved in innate immunity and fertility.
Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.
Padova, Italy. In Eur J Med Chem, 2012
New polyamine derivatives 1-8, related to the previously reported N(1),N(12)-dibenzyldodecane-1,12-diamine (Bis-Bza-Diado) and N(1)-benzyl-spermine (BD6), have been synthesized and used as "probes" (potential substrates or inhibitors) of the human monoamine oxidases (MAO A and MAO B) and Vascular-Adhesion-protein -1 (VAP-1).
Effect of natural polymorphisms in the HIV-1 CRF02_AG protease on protease inhibitor hypersusceptibility.
Rio de Janeiro, Brazil. In Antimicrob Agents Chemother, 2012
These HS-linked polymorphisms were introduced in the BD6-15 CRF02_AG molecular clone and tested for inhibition using a panel of protease inhibitors.
Cross-clade recognition of HIV-1 CAp24 by CD4+ T cells in HIV-1-infected individuals in Burkina Faso and Germany.
Heidelberg, Germany. In Open Aids J, 2008
IFN-gamma production following stimulation with a whole length CAp24 protein derived from clade B (CAp24(NL4-3)) was additionally quantified in comparison to a CAp24 protein derived from CRF02_AG (CAp24(BD6-15)) in 16 HIV-1-infected patients in Heidelberg, Germany.
Production of bioactive human beta-defensin 5 and 6 in Escherichia coli by soluble fusion expression.
Singapore, Singapore. In Protein Expr Purif, 2008
This work reports the first successful recombinant expression and purification of human beta-defensin 5 (HBD5) and human beta-defensin 6 (HBD6) in Escherichia coli.
Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.
Québec, Canada. In Biol Reprod, 2008
Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.
Beta-defensin overexpression induces progressive muscle degeneration in mice.
GeneRIF
Tokyo, Japan. In Am J Physiol Cell Physiol, 2007
The present findings may unravel a concealed linkage between the innate immune system and the pathophysiology of degenerative diseases.
Prevalence and mechanisms of decreased susceptibility to carbapenems in Klebsiella pneumoniae isolates.
Suwŏn, South Korea. In Diagn Microbiol Infect Dis, 2007
Three isolates (BD6, BD8, and KN16) exhibited decreased susceptibility to carbapenems with imipenem MICs of 1, 4, and 8 microg/mL and meropenem MICs of 4, 8, and 4, respectively.
Nutritional evaluation of different bacterial douchi.
Hangzhou, China. In Asia Pac J Clin Nutr, 2006
Lipid content of BD1, BD5 and BD6 was also significantly higher than that of AS.
An analysis of signatures of selective sweeps in natural populations of the house mouse.
Köln, Germany. In Mol Biol Evol, 2006
Single-nucleotide polymorphism typing of one sweep signature in the M. m. domesticus populations around the beta-defensin 6 locus confirms a lowered nucleotide diversity in this region and limits the potential sweep region to about 20 kb.
Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs.
Ames, United States. In J Clin Microbiol, 2004
The hypothesis in this experiment was that adenovirus expression of human beta-defensin 6 (HBD6) would diminish concurrent PIV3 infection in neonatal lambs.
Construction and characterisation of a full-length infectious molecular clone from a fast replicating, X4-tropic HIV-1 CRF02.AG primary isolate.
Heidelberg, Germany. In Virology, 2003
Furthermore, HIV-1 BD6-15 exhibited similar replication properties and virus yield as the reference B-type HIV-1 strain NL4-3.
ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.
GeneRIF
Davis, United States. In Am J Respir Cell Mol Biol, 2003
A pilot study with cRNA probes for in situ hybridization and a synthetic propeptide for the functional characterization demonstrated the tissue-/cell-specific expression and the strong antimicrobial activity of DEFB106
Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.
GeneRIF
Kumamoto, Japan. In J Immunol, 2002
The epididymis-specific expression pattern of the beta-defensin isoform mBD-6 has been characterized.
