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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

B-cell CLL/lymphoma 9-like

BCL9L, BCL9-2
Top mentioned proteins: BCL9, TCF, CAN, Armadillo, TCF4
Papers on BCL9L
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.
New
Cvekl et al., United States. In Nucleic Acids Res, Sep 2015
In lens, Pax6 directly regulates cell cycle exit via components of FGF (Fgfr2, Prox1 and Ccnd1) and Wnt (Dkk3, Wnt7a, Lrp6, Bcl9l, and Ccnd1) signaling pathways.
Nature and nurture: a case of transcending haematological pre-malignancies in a pair of monozygotic twins adding possible clues on the pathogenesis of B-cell proliferations.
New
Hokland et al., Århus, Denmark. In Br J Haematol, May 2015
Employing the method for detecting high-ranking variants by extensive annotation and relevance scoring, we also identified shared germline variants in genes of proteins interacting with B-cell receptor signalling mediators and the WNT-pathway, including IRF8, PTPRO, BCL9L, SIT1 and SIRPB1, all with possible implications in B-cell proliferation.
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells.
New
Lallemand et al., Paris, France. In Mol Cancer Res, May 2015
Here, it is revealed that WWOX also interacts with the BCL9-2, a cofactor of the Wnt/β-catenin pathway, to enhance the activity of the β-catenin-TCF/LEF (T-cell factor/lymphoid enhancer factors family) transcription factor complexes.
MiR-29b downregulates canonical Wnt signaling by suppressing coactivators of β-catenin in human colorectal cancer cells.
Karunagaran et al., Chennai, India. In J Cell Biochem, 2014
miR-29b antagonized transactivation of β-catenin target genes by downregulating coactivators of β-catenin (TCF7L2, Snail, and BCL9L) in SW480 cells.
Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.
Basler et al., Zürich, Switzerland. In Genes Dev, 2014
Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between β-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively.
The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
Brembeck et al., Göttingen, Germany. In Oncotarget, 2014
Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and human.
Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells.
Karunagaran et al., Chennai, India. In J Nat Prod, 2014
Plumbagin (1) was found to downregulate Wnt signaling when assessed by a TOPFlash/FOPFlash reporter activity assay and also decreased the expression of several coactivators and downstream targets of Wnt signaling such as β-catenin, TCF7L2, p300, Bcl9l, c-Myc, vimentin, and cyclinD1 in SW620 colorectal cancer cells.
LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.
Bienz et al., Cambridge, United Kingdom. In Cancer Res, 2014
This TNKSi insensitivity is conferred by β-catenin's association with LEF1 and BCL9-2/B9L, which accumulate during Wnt stimulation, thereby providing a feed-forward loop that converts transient into chronic β-catenin signaling.
Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units.
Kingsmore et al., Kansas City, United States. In Sci Transl Med, 2012
Prospective WGS disclosed potential molecular diagnosis of a severe GJB2-related skin disease in one neonate; BRAT1-related lethal neonatal rigidity and multifocal seizure syndrome in another infant; identified BCL9L as a novel, recessive visceral heterotaxy gene (HTX6) in a pedigree; and ruled out known candidate genes in one infant.
BCL9-2 promotes early stages of intestinal tumor progression.
GeneRIF
Birchmeier et al., Berlin, Germany. In Gastroenterology, 2011
BCL9-2 promotes early phases of intestinal tumor progression in humans and in transgenic mice. BCL9-2 increases the expression of a subset of canonical Wnt target genes but also regulates genes that are required for early stages of tumor progression.
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
GeneRIF
Akiyama et al., Tokyo, Japan. In Nat Commun, 2010
Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.
GeneRIF
Bienz et al., Cambridge, United Kingdom. In J Mol Biol, 2010
Pygo2 PHD is the only known PHD finger that is capable of interacting simultaneously with two functional ligands, B9L and BCL9.
WNT signaling pathway and stem cell signaling network.
Review
Katoh et al., Japan. In Clin Cancer Res, 2007
Nuclear complex, consisting of T-cell factor/lymphoid enhancer factor, beta-catenin, BCL9/BCL9L, and PYGO, activates transcription of canonical WNT target genes such as FGF20, DKK1, WISP1, MYC, CCND1, and Glucagon (GCG).
Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.
GeneRIF
Akiyama et al., Maebashi, Japan. In Cancer Sci, 2007
We demonstrated that nuclear B9L expression was closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
In 2003, we identified and characterized PRICKLE1, PRICKLE2, DACT1/DAPPER1, DACT2/DAPPER2, DAAM2, and BCL9L.
Crystal structure of a beta-catenin/BCL9/Tcf4 complex.
GeneRIF
Xu et al., Seattle, United States. In Mol Cell, 2006
crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.
Review
Katoh et al., Tokyo, Japan. In Cancer Biol Ther, 2006
Nuclear beta-catenin is complexed with TCF/LEF, Legless (BCL9 or BCL9L) and PYGO (PYGO1 or PYGO2) to activate transcription of CCND1, MYC, FGF18 and FGF20 genes for the cell-fate determination.
Decisions, decisions: beta-catenin chooses between adhesion and transcription.
Review
Peifer et al., Chapel Hill, United States. In Trends Cell Biol, 2005
Furthermore, Felix Brembeck and colleagues reveal that phosphorylation dissociates beta-catenin from adhesion complexes while enhancing BCL9-2 binding to promote transcription.
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