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B-cell CLL/lymphoma 7B

BCL7B
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: BCL7A, GCKR, BCL7C, TBL2, Apolipoprotein C-I
Papers on BCL7B
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway.
Mitani et al., Tokyo, Japan. In Plos Genet, 2015
Human BCL7 gene family consists of BCL7A, BCL7B, and BCL7C.
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.
Dehghan et al., Rotterdam, Netherlands. In Plos One, 2014
In addition, 5 regions (GCKR, PABPC4, BCL7B, FTO and TMEM18) had an effect on CRP largely mediated through the cardiometabolic phenotypes.
Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
Lange et al., Chapel Hill, United States. In Hum Genet, 2014
In the race-combined meta-analyses, 13 loci reached significance, including ten (CRP, TOMM40/APOE/APOC1, HNF1A, LEPR, GCKR, IL6R, IL1RN, NLRP3, HNF4A and BAZ1B/BCL7B) previously associated with CRP, and one (ARNTL) previously reported to be nominally associated with CRP.
Pleiotropic genes for metabolic syndrome and inflammation.
Borecki et al., Saint Louis, United States. In Mol Genet Metab, 2014
They map to genes MACF1, KIAA0754, GCKR, GRB14, COBLL1, LOC646736-IRS1, SLC39A8, NELFE, SKIV2L, STK19, TFAP2B, BAZ1B, BCL7B, TBL2, MLXIPL, LPL, TRIB1, ATXN2, HECTD4, PTPN11, ZNF664, PDXDC1, FTO, MC4R and TOMM40.
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.
Impact
Crabtree et al., United States. In Nat Genet, 2013
To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18.
Williams-Beuren Syndrome and Burkitt Leukemia.
Naqvi et al., Toronto, Canada. In J Pediatr Hematol Oncol, 2013
including BCL7B was confirmed.
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.
Logie et al., Nijmegen, Netherlands. In Plos One, 2011
Furthermore, SS18L1, DPF1, DPF2, DPF3, BRD9, BCL7A, BCL7B and BCL7C were identified.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Impact
Cho et al., South Korea. In Nat Genet, 2011
(in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits.
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
Chasman et al., Rotterdam, Netherlands. In Circulation, 2011
Our results confirm 7 previously known loci and introduce 11 novel loci that are implicated in pathways related to the metabolic syndrome (APOC1, HNF1A, LEPR, GCKR, HNF4A, and PTPN2) or the immune system (CRP, IL6R, NLRP3, IL1F10, and IRF1) or that reside in regions previously not known to play a role in chronic inflammation (PPP1R3B, SALL1, PABPC4, ASCL1, RORA, and BCL7B).
Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma.
Warr et al., London, United Kingdom. In Neoplasia, 2008
However, a small region of loss involving up to seven adjacent clones at 7q11.23 was observed in seven tumors and correlated with the underexpression of BCL7B.
Non-Hodgkin lymphoma in a child with Williams syndrome.
Fryssira et al., Athens, Greece. In Cancer Genet Cytogenet, 2004
Molecular DNA analysis showed a maternal deletion at 7q11.23, the locus of elastin and several other genes, including the BCL7B gene, involved in early development.
Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas.
You et al., Columbus, United States. In Oncogene, 2004
Nevertheless, when compared with the combined human ACs, 39 genes with similar expression changes in murine lung tumors and human ACs/LCCs were identified, such as the oncogene-related BCL7B, the cell cycle regulator CDK4, and the proapoptotic Endophilin B1.
Isolation of expressed sequence tags of skeletal muscle of neonatal healthy and splay leg piglets and mapping by somatic cell hybrid analysis.
von Lengerken et al., Halle, Germany. In Anim Genet, 2001
By comparison with EMBL/GenBank data we could identify nine porcine homologues to human genes (TATA box binding protein associated factor B TAF1B; B-cell CLL/lymphoma 7B BCL7B; pyruvate dehydrogenase kinase, isoenzyme 4 PDK4; ribosomal protein S10 RPS10; SPARC-like 1 SPARCL1; epithelial protein lost in neoplasm beta EPLIN; N-myc downstream-regulated gene 2 NDRG2; pleiomorphic adenoma gene like 2 PLAGL and, BCL-2 associated transcription factor short form BTFS). Eight fragments correspond to uncharacterized ESTs and 7 ESTs had no significant match with database sequences.
The BCL7 gene family: deletion of BCL7B in Williams syndrome.
Dyer et al., United Kingdom. In Gene, 1999
Here, we describe the identification of two related human genes, BCL7B and BCL7C, which share 90% identity to the amino-terminal 51 amino acids of human BCL7A, as well as 41% identity in the same region to Drosophila melanogaster, Caenorhabditis elegans, and Brugia malayi EST sequences.
Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes.
Keating et al., Salt Lake City, United States. In Hum Genet, 1998
In addition, we identify three novel genes from the common deletion region: WS-betaTRP, WS-bHLH, and BCL7B.
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