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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

B cell CLL/lymphoma 6, member B

Bcl6b, BAZF, B-cell CLL/lymphoma 6, member B, Bcl6-associated zinc finger protein
Top mentioned proteins: bcl-6, GDNF, PLZF, Thy-1, ACID
Papers on Bcl6b
Lentiviral vector-mediated transduction of goat undifferentiated spermatogonia.
New
Nasr-Esfahani et al., Mashhad, Iran. In Anim Reprod Sci, Dec 2015
Enriched cells were transduced by lentiviral vectors and subsequently analyzed for expression of THY1, PLZF, VASA, UCHL1 and BCL6B genes.
BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis.
New
Zheng et al., Hangzhou, China. In Oncotarget, Sep 2015
B cell CLL/lymphoma 6 member B (BCL6B) is expressed in many normal tissues but expressed at very low levels in cancer tissues.
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.
New
Guo et al., Beijing, China. In Oncotarget, Jun 2015
BCL6B is a potential tumor suppressor in human gastric cancer, but the regulation and mechanism of BCL6B in human hepatocellular carcinogenesis remain unclear.
Ras/ERK1/2 pathway regulates the self-renewal of dairy goat spermatogonia stem cells.
New
Hua et al., China. In Reproduction, May 2015
The expression of ETV5 and BCL6B, the downstream gene of Ras/ERK1/2 pathway, was downregulated.
The molecular signature and spermatogenesis potential of newborn chicken spermatogonial stem cells in vitro.
New
Dastpak et al., Mashhad, Iran. In In Vitro Cell Dev Biol Anim, Apr 2015
In this regard, we found that colony-forming cells (SSCs) in newborn chicken testicular cell cultures were positive for alkaline phosphatase activity and also expressed specific markers including DAZL, STRA-8, CVH, PLZF, SPRY-1, GFRα1, GDNF, POU5F1, NANOG, GPR125, THY-1, c-KIT, and BCL6B, at mRNA level.
B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice.
Yu et al., Hong Kong, Hong Kong. In Cancer Lett, 2015
B cell CLL/lymphoma 6 member B (BCL6B) is a novel tumor suppressor silenced in human cancer.
Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling.
Guo et al., Beijing, China. In Am J Cancer Res, 2014
BCL6B, a homologue of BCL6, has been reported to be frequently methylated in human gastric cancer.
Glial cell line-derived neurotrophic factor in combination with insulin-like growth factor 1 and basic fibroblast growth factor promote in vitro culture of goat spermatogonial stem cells.
Nasr-Esfahani et al., Eşfahān, Iran. In Growth Factors, 2014
Even though, the relative abundance of VASA, FGFR3, OCT4, PLZF, BCL6B and THY1 transcription factors in GDNF + IGF1 + bFGF treatment group was significantly higher than the other groups (p < 0.05).
The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter.
Hao et al., Tianjin, China. In Open Biol, 2014
The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies.
Transcriptional control of spermatogonial maintenance and differentiation.
Review
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Most of the transcription factors that have so far been identified as promoting SSC self-renewal (BCL6B, BRACHYURY, ETV5, ID4, LHX1, and POU3F1) are upregulated by glial cell line-derived neurotrophic factor (GDNF).
Identification and IVC of spermatogonial stem cells in prepubertal buffaloes.
Yang et al., Wuhan, China. In Theriogenology, 2014
For long-term culture of SSCs, proliferation studies with different factors showed that combination of 20 ng/mL GDNF, 10 ng/mL FGF2, and 1000 U/mL LIF could significantly promote number of colonies (∼two folds) and proliferation of buffalo SSCs (∼three folds) compared with those of control or single-treatment groups; furthermore, addition of these combination growth factors significantly upregulated the messenger RNA level of spermatogonial-specific and pluripotency-related markers (BCL6B, GFRA1, and POU5F1), whereas downregulated receptor tyrosine kinase (KIT).
Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer.
Yu et al., Hong Kong, Hong Kong. In Biomarkers, 2013
We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues.
THY1 as a reliable marker for enrichment of undifferentiated spermatogonia in the goat.
Nasr-Esfahani et al., Mashhad, Iran. In Theriogenology, 2013
Real-time polymerase chain reaction analysis revealed that expression of THY1, PLZF, VASA, BCL6B, and UCHL1 as SCCs characteristic genes in THY1(+) cells was significantly higher than in the initial population.
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival.
GeneRIF
Yu et al., Hong Kong, Hong Kong. In Gut, 2012
BCL6B plays a pivotal role as a potential tumour suppressor in GC. Detection of methylated BCL6B may serve as an independent biomarker for the prognosis of GC.
FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation.
GeneRIF
Shinohara et al., Kyoto, Japan. In Development, 2012
Mouse germline stem (GS) cell transfected with an activated form of Map2k1 have upregulated Etv5 and Bcl6b gene expression.
Regulation of spermatogonial stem cell self-renewal in mammals.
Review
Brinster et al., United States. In Annu Rev Cell Dev Biol, 2007
In mouse SSCs, GDNF activation upregulates expression of the transcription factor-encoding genes bcl6b, etv5, and lhx1, which influence SSC self-renewal.
Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling.
GeneRIF
Brinster et al., Philadelphia, United States. In J Biol Chem, 2007
GDNF up-regulation of Bcl6b, Erm, and Lhx1 expression through Src family kinase signaling is a key component of the intracellular mechanism for spermatogonial stem cells self-renewal.
Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.
GeneRIF
Dent et al., Indianapolis, United States. In Mol Cell Biol, 2007
Both BCL-6 and BAZF regulate hematopoietic progenitor cells homeostasis by an indirect pathway involving CD8 T cells.
The expansion and maintenance of antigen-selected CD8(+) T cell clones.
Review
Fearon, Cambridge, United Kingdom. In Adv Immunol, 2006
Superimposed on this basic scheme are a shift in the CD8(+) T cell response to type I and II interferon (IFN) from anti- to pro-proliferative and transcriptional control of replicative senescence by Bmi-1, Blimp-1, and BCL6/BCL6b.
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
GeneRIF
Fearon et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2005
BCL6b is required for the enhanced magnitude of the secondary response of memory CD8(+) T cells.
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