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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

B-cell CLL/lymphoma 10

BCL10, Carmen, CLAP
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eco, CAN, NF-kappaB, CARMA1, HAD
Papers using BCL10 antibodies
Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats.
Supplier
Sesti Giorgio, In PLoS ONE, 1997
... mouse anti-phospho-ERK1/2 (pT202/pY204), anti-phospho-JNK/SAPK (pT183/pY185), anti-IKKγ, rabbit anti-Bcl-x (BD Biosciences), rabbit anti-ERK, anti-JNK, anti-Cleaved caspase-3, anti-Bcl-10 (Cell Signaling), rabbit anti-Caspase-1- and mouse ...
Papers on BCL10
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
New
Krappmann et al., München, Germany. In Oncogene, Feb 2016
Recruitment of the β-catenin destruction complex was independent of CARMA1-BCL10-MALT1 complex formation or constitutive NF-κB activation and promoted the stabilization of β-catenin.
Actin polymerisation after FCγR stimulation of human fibroblasts is BCL10 independent.
New
de Diego et al., Madrid, Spain. In Clin Immunol, Feb 2016
UNASSIGNED: B-cell lymphoma 10 (BCL10) is not essential for actin polymerisation after FcγR stimulation in human fibroblasts.
MALT1 protease activity controls the expression of inflammatory genes in keratinocytes upon zymosan stimulation.
New
Hailfinger et al., Tübingen, Germany. In J Invest Dermatol, Feb 2016
Inhibition of the Src family of kinases or novel PKC isoforms as well as silencing of CARMA2 or BCL10 interfered with activation of MALT1 protease.
BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair.
New
Shaw et al., Edmonton, Canada. In Cell Cycle, Feb 2016
Recent studies have found BCL10 can localize to the nucleus and that this is linked to tumor aggression and poorer prognosis.
Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.
New
Ruland et al., München, Germany. In Proc Natl Acad Sci U S A, Jan 2016
CARD11(L225LI) constitutively associated with B-cell CLL/lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) to simultaneously activate the NF-κB and c-Jun N-terminal kinase (JNK) signaling cascades.
Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.
Review
New
Puel et al., Madrid, Spain. In J Allergy Clin Immunol, Nov 2015
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1).
Advances in basic and clinical immunology in 2014.
Review
New
Shearer et al., Houston, United States. In J Allergy Clin Immunol, May 2015
New genes defects causing immunodeficiency include phophoglucomutase 3 (PGM3), cytidine 5' triphosphate synthase 1 (CTPS1), nuclear factor κB-inducing kinase (NIK), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog 1 (JAGN1).
ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature.
Review
New
La Rosa et al., Lima, Peru. In Am J Surg Pathol, Mar 2015
Using an appropriate immunohistochemical panel including ACTH, β-endorphin, trypsin, and BCL10 it is possible to recognize ACTH-secreting PanNETs and to distinguish them from the very aggressive ACTH-secreting ACCs.
The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.
Review
Warnatz et al., Vancouver, Canada. In J Allergy Clin Immunol, 2014
In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)-B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex.
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.
Impact
Sun et al., Houston, United States. In Immunity, 2014
We have further shown that TCR-stimulated glutamine uptake and mTORC1 activation also required a TCR signaling complex composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.
Isolated gastric amyloidoma in the setting of marginal zone MALT lymphoma: case report and review of the literature.
Review
Saldinger et al., In Conn Med, 2014
Immunohistochemical staining of the neoplastic lymphocytes revealed expression of CD20, bcl-2, bcl-10, Ki-67 proliferative index of 5%, and lambda light chain restriction.
A new "brew" of MALT1 inhibitors.
Impact
Staudt et al., Bethesda, United States. In Cancer Cell, 2013
The activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) is an aggressive lymphoma that is addicted to NF-κB signaling through the CARD11-BCL10-MALT1 complex.
Expression of BCL10 in cervical cancer has a role in the regulation of cell growth through the activation of NF-κB-dependent cyclin D1 signaling.
GeneRIF
Chen et al., Taipei, Taiwan. In Gynecol Oncol, 2012
BCL10 plays an important role in controlling the growth of cervical cancer cells through NF-kappaB dependent cyclin D1 regulation.
Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
Impact
GeneRIF
Schaefer et al., Bethesda, United States. In Immunity, 2012
TCR engagement triggers the degradation of Bcl10 in primary effector T cells but not in naive T cells. It promoted K63 polyubiquitination of Bcl10, causing Bcl10 association with the autophagy adaptor p62.
Inhibition of caspase-8 activity caused by overexpression of BCL10 contributes to the pathogenesis of high-grade MALT lymphoma.
GeneRIF
Zhang et al., Beijing, China. In Pediatr Blood Cancer, 2012
Our data demonstrate a novel effect of overexpressed BCL10 in the pathogenesis of high-grade MALT lymphoma by increasing expression of API2 and it then forming a protein complex with BCL10/caspase-8 leading to caspase-8 activity suppression.
Forkhead transcription factor FOXO3a protein activates nuclear factor κB through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation.
GeneRIF
Fang et al., Shanghai, China. In J Biol Chem, 2012
FOXO3a promotes cell survival via BCL10/NF-kappaB in serum starvation
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.
Impact
Sasakawa et al., Tokyo, Japan. In Nature, 2012
Consequently, the E2 ubiquitin-conjugating activity required for TRAF6 activation is inhibited, allowing S. flexneri OspI to modulate the diacylglycerol-CBM (CARD-BCL10-MALT1) complex-TRAF6-nuclear-factor-κB signalling pathway.
Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.
GeneRIF
Ruley et al., Nashville, United States. In J Immunol, 2012
We show that CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1
The SYK tyrosine kinase: a crucial player in diverse biological functions.
Review
Impact
Tybulewicz et al., Budapest, Hungary. In Nat Rev Immunol, 2010
SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome.
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
Impact
Lenardo et al., Bethesda, United States. In Nature, 2009
Antigen receptor stimulation assembles an NF-kappaB activating platform containing the scaffold protein CARMA1 (also called CARD11), the adaptor BCL10 and the paracaspase MALT1 (the CBM complex), linked to the inhibitor of NF-kappaB kinase complex, but signal transduction is not fully understood.
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