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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BCL2-like 1

Bcl-xL, bcl-X
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: bcl-2, PrP, Bax, caspase-3, V1a
Papers using Bcl-xL antibodies
Microtubules and cadherins: a neglected partnership.
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Ushio-Fukai Masuko, In PLoS ONE, 2008
... Sigma), mouse anti-Bcl-2 (1/500; Transduction Laboratories, Becton Dickinson Europe, Le Pont de Claix, France), rabbit anti-Bcl-xL (1/1000; Cell Signaling Technology), rabbit anti-Bim (1/1000; ...
Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
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Goel Ajay, In PLoS ONE, 2008
... Polyclonal antibodies against cyclin D1, matrix metalloproteinase 9 (MMP-9), survivin, COX-2, c-Myc, Bcl-2, and Bcl-xL were obtained from Santa Cruz Biotechnology.
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
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Jin Dong-Yan, In PLoS ONE, 2008
... Mobility Shift Assay (EMSA) - Sequences of the Bcl-xL promoter oligonucleotide probes that were used include Bcl-xL, 5′-CAGAATCTTATCTTGGCTTTGG-3′ and the probe with mutation in the binding site is: Bcl-xL-mut, ...
Fertility comparison between wild type and transgenic mice by in vitro fertilization.
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Rutherford Suzannah, In PLoS ONE, 2008
... Bcl-x [13] and heterozygous transgenic C57BL/6J VavP- ...
Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling
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Park Kyoung Chan et al., In Oxidative Medicine and Cellular Longevity, 2007
... Antibodies recognizing phospho-Akt1/2/3 (Ser473, sc-7985-R), total-Akt (sc-8312) and Bcl-xL (sc-7195) were obtained from Santa Cruz Biotechnology, Inc ...
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Papers on Bcl-xL
An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
New
Umar et al., Kansas City, United States. In Carcinogenesis, Feb 2016
The AR seed extract (AR extract) inhibited proliferation and colony formation in a dose and time dependent manner and promoted apoptosis as was evidenced by cleavage of PARP and increased expression of Bax accompanying reduced levels of BCL-xl protein in HCT116 and SW480 cells, respectively.
Biological evaluation of 2-arylidene-4, 7-dimethyl indan-1-one (FXY-1): a novel Akt inhibitor with potent activity in lung cancer.
New
Chandramoorthy et al., Abhā, Saudi Arabia. In Cancer Chemother Pharmacol, Feb 2016
Western blot analysis revealed dephosphorylation of Akt (Ser 473) with activation of p53, Bax, Bak, Bid and reduction in Bcl-2 and Bcl-xL levels.
Kingianins O-Q: Pentacyclic polyketides from Endiandra kingiana as inhibitor of Mcl-1/Bid interaction.
New
Awang et al., Kuala Lumpur, Malaysia. In Fitoterapia, Feb 2016
In addition, in contrast with the binding affinity for Bcl-xL, the levorotatory enantiomers of kingianins G, H and J exhibited similar binding affinities for Mcl-1 than their dextrorotatory counterparts, indicating that the two anti-apoptotic proteins have slightly different binding profiles.
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling.
Review
New
Bultynck et al., Leuven, Belgium. In Biochim Biophys Acta, Feb 2016
An important aspect of this is the identification of several major oncogenes, including Bcl-2, Bcl-XL, Mcl-1, PKB/Akt, and Ras, and tumor suppressors, such as p53, PTEN, PML, BRCA1, and Beclin 1, as direct and critical regulators of Ca(2+)-transport systems located at the ER membranes, including IP3 receptors and SERCA Ca(2+) pumps.
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
New
Impact
Zhou et al., Little Rock, United States. In Nat Med, Jan 2016
To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug.
Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.
Review
New
Howell et al., Norwich, United Kingdom. In Chemmedchem, Jan 2016
The pro-survival members of the Bcl-2 family, including Bcl-2, Bcl-xL , and Mcl-1, are commonly overexpressed in a number of human cancers.
Glycogen synthase kinase-3β regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-κB pathway in hepatocellular carcinoma.
New
Liang et al., Qingdao, China. In Oncol Lett, Dec 2015
The results of the current study demonstrated that inhibition of GSK-3β significantly impairs the expression of the nuclear factor-κB (NF-κB) target genes Bcl-xL and clAP2 in HCC cells (P<0.05).
Bcl-xL promotes metastasis independent of its anti-apoptotic activity.
New
Du et al., New York City, United States. In Nat Commun, Dec 2015
Bcl-xL suppresses mitochondria-mediated apoptosis and is frequently overexpressed in cancer to promote cancer cell survival.
Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species.
Review
New
Um, Seoul, South Korea. In Oncotarget, Dec 2015
UNASSIGNED: Although Bcl-2 family proteins were originally identified as key regulators of apoptosis, an impressive body of evidence has shown that pro-survival members of the Bcl-2 family, including Bcl-2, Bcl-XL, and Bcl-w, can also promote cell migration, invasion, and cancer metastasis.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
New
Impact
Cheng et al., Kettering, United States. In Nat Cell Biol, Oct 2015
BCL-2, BCL-XL and MCL-1 inhibit both modes of BAX-BAK activation by sequestering activator BH3s and 'BH3-exposed' monomers of BAX-BAK, respectively.
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective.
Review
New
Kim et al., Inch'ŏn, South Korea. In Int Neurourol J, Sep 2015
IL-33 stimulates mast cell proliferation by activating the ST2/Myd88 pathway; increases mast cell survival by the activation of survival proteins such as Bcl-XL; and promotes the growth, development, and maturation of mast cell progenitors.
MYC Is a Major Determinant of Mitotic Cell Fate.
New
Impact
Taylor et al., San Diego, United States. In Cancer Cell, Aug 2015
Myc achieves this by upregulating a cluster of redundant pro-apoptotic BH3-only proteins and suppressing pro-survival Bcl-xL.
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.
Review
Shin et al., Seoul, South Korea. In Int J Mol Sci, 2014
TOB1 antagonizes the v-akt murine thymoma viral oncogene (AKT) signaling and induces cancer cell apoptosis by activating BCL2-associated X (BAX) protein and inhibiting the BCL-2 and BCL-XL expressions.
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.
Impact
Wang et al., Dalian, China. In Cancer Cell, 2014
Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and coexpression of Bcl-xL partially reverses the RBM4-mediated tumor suppression.
Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage.
Impact
Zeiser et al., Freiburg, Germany. In Nat Med, 2014
Enhanced survival of Bcl-xL transgenic neutrophils increased GVHD severity.
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.
GeneRIF
Shoshan-Barmatz et al., Beersheba, Israel. In J Biol Chem, 2012
Interfering with Bcl-xL binding to the mitochondria by VDAC1-based peptides may serve to induce apoptosis in cancer cells.
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.
GeneRIF
Kim et al., Taejŏn, South Korea. In Biochem Biophys Res Commun, 2012
PKM2 affected gastric cancer cell survival by regulating Bcl-xL at the transcriptional level. PKM2 knockdown partially affected the stability of NF-kB subunit p65, suggesting that post-translational regulation of p65 by PKM2 is one of plausible mechanisms for the increased cell growth.
Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells.
GeneRIF
Pandol et al., Pasadena, United States. In Biochem Biophys Res Commun, 2012
These results show a novel role played by the Bcl-xL:Bim interaction in regulating proliferation of pancreatic cancer cells at the expense of apoptosis.
Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint.
GeneRIF
Bertrand et al., Montréal, Canada. In Cell Cycle, 2012
phospho-Bcl-xL(Ser62) binds to and co-localizes with Cdk1(cdc2), the key cyclin-dependent kinase required for entry into mitosis.
FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells.
GeneRIF
Choi et al., Ch'ŏngju, South Korea. In Bmb Rep, 2012
A subset of Bcl2 family proteins are the targets of FGF-2 signaling that promotes the survival of ATDC5 cells.
More papers using Bcl-xL antibodies
Cytotoxicity effects induced by Zearalenone metabolites, alpha Zearalenol and beta Zearalenol, on cultured Vero cells
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Svasti Jisnuson et al., In Journal of Hematology & Oncology, 2007
... Mouse monoclonal antibodies to cytochrome c, Bax and Bcl-2 and rabbit polyclonal antibody to Bcl-xL, and horseradish peroxidase (HRP) conjugated secondary antibodies were purchased from Abcam, Cambridge, UK ...
Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures
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Park Yong-Chon et al., In Psychiatry Investigation, 2007
... BCL-xL antibody was purchased from Cell Signaling Technology (Beverly, MA, USA) ...
AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development
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Casellas Rafael et al., In The Journal of Experimental Medicine, 2007
... AID-deficient Bcl-xL transgenic mice develop delayed atypical ...
Anti-apoptotic activity of Bcl-2 is enhanced by its interaction with RTN3.
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Linden Rafael, In PLoS ONE, 2006
... Monoclonal antibodies directed against PARP, Cytochrome c (7H8.2C12) and polyclonal against Bcl-xL were from BD Biosciences, polyclonal against Rab4 was ...
Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells
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Ségui Bruno et al., In International Journal of Molecular Sciences, 2003
... and used at 1/1000 dilution; monoclonal anti-β-actin (clone AC-15; 5 μg/mL) was obtained from Sigma; monoclonal anti-Bcl-xL (clone 2H12, 1 μg/mL) and anti-RIP (clone G322-2, 0.25 μg/mL) were purchased from BD Biosciences (Le Pont-De-Claix, France).
Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage
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Oteiza Patricia I. et al., In Neurotoxicity Research, 2001
... , Bcl-xL, and β-tubulin were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Role of palmitoyl-protein thioesterase in cell death: Implications for infantile neuronal ceroid lipofuscinosis
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Wu Yu-Jen et al., In Marine Drugs, 2000
... Antibodies against caspase-3, cleaved caspase-3, caspase-8, caspase-9, cleaved caspase-9 and Bcl-xL were from Cell Signaling Technology (Danvers, MA, USA) ...
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
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Virgin Skip, In PLoS Pathogens, 1999
... A549 cells stably overexpressing Bcl-xL were generated by retroviral integration using the pLNCX2 vector system with neomycin selection marker from Clontech (Palo Alto, California, United ...
Bcl-2 inhibits early apoptotic events and reveals post-mitotic multinucleation without affecting cell cycle arrest in human epithelial tumor cells exposed to etoposide
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Ko Kwang Ho et al., In Journal of Biomedical Science, 1998
... β-actin and Bcl-xL antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
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Asano T et al., In British Journal of Cancer, 1997
... Technology Inc.), ERK (Cell Signaling Technology Inc.), cleaved poly(ADP-ribose) polymerase (PARP) (Cell Signaling Technology Inc.), Bcl-xl (Cell Signaling Technology Inc.), Bcl-2 (Cell ...
Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats.
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Sesti Giorgio, In PLoS ONE, 1997
... Western blot experiments were performed with mouse anti-phospho-ERK1/2 (pT202/pY204), anti-phospho-JNK/SAPK (pT183/pY185), anti-IKKγ, rabbit anti-Bcl-x (BD Biosciences), rabbit anti-ERK, anti-JNK, anti-Cleaved ...
Injected cytochrome c induces apoptosis
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Martinou Jean-Claude et al., In The Journal of Cell Biology, 1997
... terminus of human Bcl-x was from Santa Cruz Biotechnology ...
Processing of engulfed apoptotic bodies yields T cell epitopes
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Ferguson Thomas A. et al., In The Journal of Experimental Medicine, 1996
... B6-bcl-xL transgenic mice ( ...
Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses
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Reiner Steven L. et al., In The Journal of Experimental Medicine, 1996
... DO11.10 TCR transgenic, and Bcl-xL transgenic DO11.10 TCR transgenic mice ...
Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells
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Huh Sung-Oh et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 1995
... Antibodies against caspase-3, cyclin D1, Mcl-1, Bcl-2, and Bcl-xL were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
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