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B-cell CLL/lymphoma 3

Bcl-3
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, bcl-2, NF-kappaB, ACID, HAD
Papers on Bcl-3
Bioinformatics analyses of differentially expressed genes associated with acute myocardial infarction.
New
Sun et al., Shenyang, China. In Cardiovasc Ther, Feb 2016
Besides, 4 transcription factors (TFs), including nuclear receptor subfamily 2, group C, member 2 (NR2C2), MYC associated factor X (MAX), general transcription factor IIIC, polypeptide 2, beta 110 kDa (GTF3C2), and B-cell CLL/lymphoma 3 (BCL3) were identified.
Low expression of IL-6 and TNF-α correlates with the presence of the nuclear regulators of NF-κB, IκBNS and BCL-3, in the uterus of mice.
New
Rodríguez-Martínez et al., Mexico. In Mol Immunol, Dec 2015
IκBNS and BCL-3 are negative nuclear regulators of NF-κB activity that regulate IL-6 and TNF-α transcription, respectively.
Heterolysis of H2 Across a Classical Lewis Pair, 2,6-Lutidine⋅BCl3 : Synthesis, Characterization, and Mechanism.
New
Camaioni et al., Richland, United States. In Chemistry, Nov 2015
Conversion of the intermediate 2-(BHCl2 CH2 )-6-Me(C5 H3 NH) to Lut⋅BHCl2 may occur by intermolecular steps involving proton/hydride transfers to Lut/BCl3 .
BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.
New
Algül et al., München, Germany. In Gastroenterology, Nov 2015
We analyzed the contribution of B-cell CLL/lymphoma 3 (BCL3), a transcription factor that associates with NF-κB, in control of sterile inflammation in the pancreas and biliary system of mice.
Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia.
Swisshelm et al., Denver, United States. In Mol Cytogenet, 2014
Chromosomal abnormalities associated with CLL include trisomy 12 and IGH;BCL3 rearrangement [t(14;19)(q32;q13)] that juxtaposes a proto-oncogenic gene BCL3 and an immunoglobulin heavy chain, a translocation that may be associated with shorter survival.
MYC/BCL2 double-hit high-grade B-cell lymphoma.
Review
Medeiros et al., Nashville, United States. In Adv Anat Pathol, 2013
Double-hit lymphoma (DHL) has been defined by others as a B-cell lymphoma with MYC/8q24 rearrangement in combination with a translocation involving another gene, such as BCL2, BCL3, or BCL6.
[Synthetic studies on natural products with aromatic nitrogen heterocycles based on development of the methods for the formation of aryl carbon-nitrogen bond].
Review
Okano, In Yakugaku Zasshi, 2012
The utility of this reaction has been fully demonstrated through a total synthesis of yatakemycin, which features the regioselective ring opening of (S)-epichlorohydrin with 2,6-dibromophenyllithium species and the efficient deprotection of benzyl groups of aryl benzyl ether with BCl3 in the presence of pentamethylbenzene.
Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance.
GeneRIF
Szabo et al., Worcester, United States. In J Leukoc Biol, 2012
acute alcohol treatment induces molecular signatures of TLR4/LPS tolerance through the induction of Bcl-3
Inhibition of Bcl3 gene expression mediates the anti-proliferative action of estrogen in pituitary lactotrophs in primary culture.
GeneRIF
Arita et al., Japan. In Mol Cell Endocrinol, 2011
These results suggest that inhibition of Bcl3 expression is involved in the anti-proliferative action of estrogens in pituitary lactotrophs in culture.
The IκB family member Bcl-3 coordinates the pulmonary defense against Klebsiella pneumoniae infection.
GeneRIF
Siebenlist et al., Bethesda, United States. In J Immunol, 2011
Bcl-3 is critically involved in lung defense against Klebsiella pneumoniae, modulating functions of several cells to facilitate efficient clearance of bacteria.
Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3.
GeneRIF
Jackman et al., Boston, United States. In Plos One, 2010
showed increased Bcl-3 binding to kappaB sites in unloaded muscle and thus were direct targets of Bcl-3
Activation of oxidative stress-regulated Bcl-3 suppresses CTCF in corneal epithelial cells.
GeneRIF
Lu et al., Torrance, United States. In Plos One, 2010
a novel mechanism for regulatory control of CTCF in UV stress-induced human corneal epithelial cells, which requires activation and formation of Bcl-3/p50 complex through a noncanonical NF-kappaB pathway
NF-κB as a potential therapeutic target in myelodysplastic syndromes and acute myeloid leukemia.
Review
Alimena et al., Roma, Italy. In Expert Opin Ther Targets, 2010
NF-κB and associated regulatory factors (IκB kinase subunits and bcl-3) are implicated in hematological and solid tumour malignancies.
Energy-conversion properties of vapor-liquid-solid-grown silicon wire-array photocathodes.
Impact
Lewis et al., Pasadena, United States. In Science, 2010
Using a copper-catalyzed, vapor-liquid-solid-growth process, SiCl4 and BCl3 were used to grow ordered arrays of crystalline p-type silicon (p-Si) microwires on p+-Si(111) substrates.
Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors)
Review
Hodder et al., Bethesda, United States. In Unknown Journal, 2009
Quantitative PCR experiments demonstrated that probe ML116 inhibits transcription of the STAT3-regulated gene BCL3.
Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators)
Review
Hodder et al., Bethesda, United States. In Unknown Journal, 2009
QPCR experiments further confirm that the probe upregulates transcription of the oncogene BCL3.
Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions.
Impact
Siebenlist et al., Bethesda, United States. In Immunity, 1997
Chromosomal translocations of bcl-3 are associated with chronic B cell lymphocytic leukemias.
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B.
Impact
Scheidereit et al., Berlin, Germany. In Nature, 1992
We show here that the proto-oncogene bcl-3, believed to be involved in certain human B-cell leukaemias, encodes a protein that functions as an I kappa B-like molecule for native NF-kappa B but is specific for the p50 subunit.
Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.
Impact
Siebenlist et al., Bethesda, United States. In Nature, 1990
The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans, as well as in the putative human oncogene bcl-3 and in the ankyrin protein.
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.
Impact
McKeithan et al., Chicago, United States. In Cell, 1990
A gene, bcl-3, is found on chromosome 19 adjacent to the breakpoints in the translocation t(14;19)(q32;q13.1),
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