MYC Alterations in Diffuse Large B-Cell Lymphomas.
Barcelona, Spain. In Semin Hematol, 30 Apr 2015
MYC rearrangements, and to a lesser extent gene amplifications, have been detected in approximately 5% to 14% of diffuse large B-cell lymphoma (DLBCL) and these alterations are frequently associated with BCL2 or BCL6 rearrangements.
The Interplay between PP2A and microRNAs in Leukemia.
Houston, United States. In Front Oncol, Dec 2014
Loss of PP2A results in failure to turn off survival signaling cascades that drive drug resistance such as those regulated by protein kinase B. PP2A is responsible for modulating function and controlling expression of tumor suppressors such as p53 and oncogenes such as BCL2 and MYC.
How cell death shapes cancer.
Berlin, Germany. In Cell Death Dis, Dec 2014
Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones.
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
More papers using
Villejuif, France. In Nature, Oct 2014
Resistance to treatment and maintenance of eIF4F complex formation is associated with one of three mechanisms: reactivation of MAPK signalling, persistent ERK-independent phosphorylation of the inhibitory eIF4E-binding protein 4EBP1 or increased pro-apoptotic BCL-2-modifying factor (BMF)-dependent degradation of eIF4G.
Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
In Gastroenterology Research and Practice, 2001
... calculation, four slides carrying two-sections each were immunohistochemically examined for the p53, Ki-67, Bax, and Bcl-2 expression (Biogenex Laboratories, Inc., San Ramon, ... Cdk5 phosphorylates p53 and regulates its activity.
In PLoS ONE, 2001
... to β-actin, Tau, β tubulin III, RARα, RARβ, p-ERK p-JNK, p-p38, p21, caspase 3, Bax, Bcl-2 and HRP-labeled secondary anti-goat, anti-mouse, and anti-rabbit antibodies were all purchased from Santa Cruz Biotechnology (Santa Cruz, USA) ... Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... (1:200, sc-28226, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Bcl-xL (1:500, 610209, BD Transduction Laboratories), anti-Bcl-2 (1:200, sc-492, Santa Cruz Biotechnology), anti-p-eIF2 ... cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
In Evidence-based Complementary and Alternative Medicine : eCAM, 1990
... Anti-Cdc25c (Cell Signaling Technology Inc., Danvers, MA), anticyclin B1 (Cell Signaling Technology Inc., Danvers, MA), anti-Bcl2 (Cell Signaling Technology Inc., Danvers, MA), ...