How I treat Waldenstrom macroglobulinemia.
Boston, United States. In Blood, 22 Jun 2015
Investigational therapies under development for WM include agents that target MYD88, CXCR4, BCL2, and CD27/CD70 signaling, novel proteasome inhibitors, and chimeric antigen receptor modified T-cell therapy.
MYC alterations in diffuse large B-cell lymphomas.
Barcelona, Spain. In Semin Hematol, 30 Apr 2015
MYC rearrangements, and to a lesser extent gene amplifications, have been detected in approximately 5% to 14% of diffuse large B-cell lymphoma (DLBCL) and these alterations are frequently associated with BCL2 or BCL6 rearrangements.
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
More papers using
Villejuif, France. In Nature, Oct 2014
Resistance to treatment and maintenance of eIF4F complex formation is associated with one of three mechanisms: reactivation of MAPK signalling, persistent ERK-independent phosphorylation of the inhibitory eIF4E-binding protein 4EBP1 or increased pro-apoptotic BCL-2-modifying factor (BMF)-dependent degradation of eIF4G.
Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
In Gastroenterology Research and Practice, 2001
... calculation, four slides carrying two-sections each were immunohistochemically examined for the p53, Ki-67, Bax, and Bcl-2 expression (Biogenex Laboratories, Inc., San Ramon, ... Cdk5 phosphorylates p53 and regulates its activity.
In PLoS ONE, 2001
... to β-actin, Tau, β tubulin III, RARα, RARβ, p-ERK p-JNK, p-p38, p21, caspase 3, Bax, Bcl-2 and HRP-labeled secondary anti-goat, anti-mouse, and anti-rabbit antibodies were all purchased from Santa Cruz Biotechnology (Santa Cruz, USA) ... Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... (1:200, sc-28226, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Bcl-xL (1:500, 610209, BD Transduction Laboratories), anti-Bcl-2 (1:200, sc-492, Santa Cruz Biotechnology), anti-p-eIF2 ... cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
In Evidence-based Complementary and Alternative Medicine : eCAM, 1990
... Anti-Cdc25c (Cell Signaling Technology Inc., Danvers, MA), anticyclin B1 (Cell Signaling Technology Inc., Danvers, MA), anti-Bcl2 (Cell Signaling Technology Inc., Danvers, MA), ...