GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
B-cell CLL/lymphoma 2
bcl-2
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Top mentioned proteins:
Bax, PrP, CAN, p53, V1a
Papers using
bcl-2
antibodies
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene.
Supplier
In PLoS ONE, 2010
The RB-E2F1 pathway regulates autophagy.
Supplier
In PLoS ONE, 2010
... Stable empty vector control cells and Bcl-2 over-expressing clones were generated using standard gene transfer techniques and selection in Geneticin (Life Technologies).
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF.
Supplier
In PLoS ONE, 2009
... Antibodies against Bcl-2 (N-19) and 14-3-3 (C-16) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Supplier
In Cell death and differentiation, 2008
... Bcl-2-transgenic mice ...
Microtubules and cadherins: a neglected partnership.
more suppliersSupplier
In PLoS ONE, 2008
... Lake Placid, NY), mouse anti-phospho-Erk1/2 (1/10000; Sigma), mouse anti-Bcl-2 (1/500; Transduction Laboratories, Becton Dickinson Europe, Le Pont de ...
Papers on
bcl-2
Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biologic heterogeneity of the disease.
New
Boston, United States. In Blood, Feb 2016
The remaining 2 DLBCL PDX models were GCB-type, with characteristic alterations of GNA13, CREBBP and EZH2, and chromosomal translocations involving IgH and either BCL2 or MYC.
Venetoclax Adds a New Arrow Targeting Relapsed CLL to the Quiver.
New
Impact
Columbus, United States. In Cancer Cell, Feb 2016
A recent paper by Roberts and colleagues describes an additional therapeutic target by reporting encouraging clinical results with venetoclax, an inhibitor of the antiapoptotic protein BCL2.
The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.
New
Tabrīz, Iran. In Bosn J Basic Med Sci, Feb 2016
Applying quantitative real-time polymerase chain reaction, we measured Six1, B-cell lymphoma/leukemia(BCL-2), BAX, and P53 mRNA expression levels in both non-resistant and resistant cells.
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
New
Impact
Little Rock, United States. In Nat Med, Jan 2016
To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
New
Catania, Italy. In Pathol Res Pract, Jan 2016
The diagnosis was confirmed in the excised specimen, which exhibited a tumor with an immunohistochemical profile consistent with SFT, including diffuse expression of CD34, CD99 and bcl2.
Novel targeted therapeutics for mantle cell lymphoma - What's on the horizon?
Review
New
Villejuif, France. In Expert Rev Hematol, Jan 2016
Several other molecules are currently being evaluated such as cyclin dependent kinase 4/6 (CDK4/6), phosphoinositide 3-kinase (PI3K), B cell lymphoma-2 (BCL2) and Poly ADP-ribose polymerase (PARP) inhibitors.
The Deadly Landscape Of Pro-Apoptotic BCL-2 Proteins In the Outer Mitochondrial Membrane.
Review
New
New York City, United States. In Febs J, Jan 2016
In the past two decades, significant efforts have focused on understanding the function of the BCL-2 proteins, a complex family of pro-survival and pro-apoptotic alpha helical proteins that directly control the mitochondrial pathway of apoptosis.
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia.
New
Impact
Melbourne, Australia. In N Engl J Med, Jan 2016
Venetoclax has a distinct mechanism of action; it targets BCL2, a protein central to the survival of CLL cells.
Using the pathology report in initial treatment decisions for diffuse large B-cell lymphoma: time for a precision medicine approach.
Review
New
Rochester, United States. In Hematology Am Soc Hematol Educ Program, Jan 2016
Rearrangement of the myc oncogene occurs in ∼10% of patients with DLBCL, and confers a very poor prognosis with standard R-CHOP, particularly when there is concomitant rearrangement of bcl-2, a condition referred to as "double-hit" DLBCL.
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
New
Kwangju, South Korea. In Sci Rep, Dec 2015
NFAT1 KO T cells displayed a reduced expression of apoptosis associated BCL-2/BH3 family members.
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
New
Karnāl, India. In Domest Anim Endocrinol, Dec 2015
FSH supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, BCL2-associated X protein (BAX), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as B-cell lymphoma 2 (BCL2) and X-linked inhibitor of apoptosis protein (XIAP) in cumulus cells of mature oocyte.
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
New
Impact
Leipzig, Germany. In Nat Genet, Nov 2015
Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples.
Double-hit and double-protein-expression lymphomas: aggressive and refractory lymphomas.
Review
New
Impact
Lyon, France. In Lancet Oncol, Nov 2015
Double-hit lymphoma (DHL) is a subgroup of aggressive lymphomas with both MYC and BCL2 gene rearrangements, characterised by a rapidly progressing clinical course that is refractory to aggressive treatment and short survival.
Genomic classification of lung cancer: toward a personalized treatment.
Review
New
In Tunis Med, Jun 2015
This has been reported to an inactivation of PTEN resulting in an activation of the PI3K pathway (8).Other authors reported the amplification of the proto-oncogene MET orthe BCl2-interacting mediator of cell death (BIM) (9).
Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective.
Review
Seoul, South Korea. In Int J Mol Sci, 2014
TOB1 antagonizes the v-akt murine thymoma viral oncogene (AKT) signaling and induces cancer cell apoptosis by activating BCL2-associated X (BAX) protein and inhibiting the BCL-2 and BCL-XL expressions.
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2.
GeneRIF
Hangzhou, China. In Febs Lett, 2012
Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2
BCL2 genetic variants are associated with acute kidney injury in septic shock*.
GeneRIF
Boston, United States. In Crit Care Med, 2012
Genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a single nucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury.
Biomarkers of progestin therapy resistance and endometrial hyperplasia progression.
GeneRIF
Seattle, United States. In Am J Obstet Gynecol, 2012
No association was found between Bcl-2 expression and disease persistance/progression in endometrial hyperplasia treated with progestins.
Clinical value of serum hepatocyte growth factor, B-cell lymphoma-2 and nitric oxide in primary breast cancer patients.
GeneRIF
Cairo, Egypt. In Eur Rev Med Pharmacol Sci, 2012
Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
The clinicopathological significance of Bax and Bcl-2 protein expression with tumor infiltrating lymphocytes in ovarian carcinoma.
More papers using
bcl-2
antibodies
GeneRIF
İzmir, Turkey. In Neoplasma, 2011
Low bcl-2 expression is associated with response to therapy in ovarian carcinoma.
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy.
Supplier
In PLoS ONE, 2008
... Antibodies were obtained from the following sources: monoclonal mouse anti Bcl-2 (Santa Cruz Biotechnology, sc-7382), polyclonal rabbit anti ...
G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis
Supplier
In Nucleic Acids Research, 2008
... The anti-Bcl-2 monoclonal antibody was purchased from Dako (Carpinteria, CA, USA) ...
Nonpharmacological approaches to improve bone health and reduce osteoporosis.
Supplier
In PLoS ONE, 2007
... BCL2 transgenic mice at 2 weeks (E), ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Supplier
In Journal of Hematopathology, 2007
... Fluorescent in situ hybridization analysis was performed on formalin-fixed tissue specimens, using a BCL-2 split signal DNA probe (Y5407, DAKO Cytomation, Denmark A/S) ...
Apoptosis signal-regulating kinase 1 in stress and immune response
Supplier
In Chemical Research in Toxicology, 2007
... Bcl-2 was purchased from DAKO, anticatalase antibody was from ...
Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53.
Supplier
In PLoS ONE, 2006
... Anti–Bcl-2 (Ab-1) antibody was purchased from Merck Biosciences (Darmstadt, Germany) ...
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Supplier
In Cell Death & Disease, 2006
... bcl-2-transgenic mice have been described ...
Significance of liquefaction degeneration in oral lichen planus: a study of its relationship with apoptosis and cell cycle arrest markers
Supplier
In Medicina Oral, Patología Oral y Cirugía Bucal, 2006
... were incubated for 40 minutes at room temperature with monoclonal antibodies against p53 (NCI-953DO-7) and bcl-2 proteins (mouse clone 124), both antibodies were purchased from Dako (Carpinteria, CA) ...
Pulmonary and systemic effects of inhaled PACAP38 in healthy male subjects
Supplier
In The FASEB Journal, 2006
... Munich, Munich, Germany) as an antibody against the C terminus of human APP; anti-neprilysin (56C6) and anti-Bcl-2 (C-2; Santa Cruz Biotechnology, Heidelberg, Germany); and anti-pro-brain-derived ...
Neuronal conduction of excitation without action potentials based on ceramide production
Supplier
In PLoS ONE, 2006
... Antibody to Bcl-2 came from Dako (Glostrup, Denmark) ...
Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Supplier
In The Journal of Experimental Medicine, 2006
... Overexpression of Bcl-2 in transgenic mice decreases apoptosis and ...
Improving the solubility and pharmacological efficacy of curcumin by heat treatment
Supplier
In Journal of Translational Medicine, 2006
Elimination of surface debris generated by KrF excimer laser ablation of polyimide
Supplier
In Molecular therapy : the journal of the American Society of Gene Therapy, 2005
... L-NuBCP-9-R8 was from Thermo Fisher Scientific (Ulm, Germany), D-NuBCP-9-r8 (Bcl-2 Converter) was from Merck KGAa (Darmstadt, Germany) and ...
Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2005
... The antibodies for caspase-3 and Bcl-2 were purchased from BD Biosciences (San Diego, CA), while ...
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
Supplier
In PLoS ONE, 2005
... Mouse anti Bcl-2 antibody was purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA) ...
Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis
Supplier
In PPAR Research, 2005
... The primary antibodies directed at Bax and Bcl-2 was obtained from Santa Cruz Biotechnology, Inc ...
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells.
Supplier
In PLoS ONE, 2005
... vav-bcl2 transgenic ( ...
Combined Adjuvant Cisplating and Ifosfamide Chemotherapy and Radiotherapy for Malignant Mixed Mullerian Tumors of the Uterus
Supplier
In World Journal of Surgical Oncology, 2005
... Bcl-2Clone 1241/20Dako ...
Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis
Supplier
In Head and Neck Pathology, 2004
... Dako), 1B16 (CD56; Novocastra), 5A4 (p80; Novocastra), SP4 (Cyclin D1; Nichirei Co., Tokyo, Japan), 124 (bcl-2; Dako), AE1/3 (cytokeratin; Dako) and ...
An essential role for c-FLIP in the efficient development of mature T lymphocytes
Supplier
In The Journal of Experimental Medicine, 2004
... Al Singer for the Bcl-2 transgenic mice ...
Bcl-2 as prognostic factor in head and neck squamous cell carcinoma
Supplier
In World Journal of Surgical Oncology, 2004
... Anti-Bcl-2 BH3 (AP1303a) was from Abgent.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
Supplier
In Molecular Cancer, 2004
... Antibodies against total Lck, Lyn, Blk, Igα, cyclin D2, Egr-1(C-19), ERK1, Bcl-XL and Bcl-2 were obtained from Santa Cruz Biotechnology, Inc ...
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
Supplier
In PLoS ONE, 2003
... Polyclonal antibodies against beta-actin, caspase-3, PARP, cytochrome c, Bcl-2, Tom-40 and FITC-conjugated secondary antibodies were purchased from Santa Cruz Biotechnology Inc ...
Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
Supplier
In The Journal of Experimental Medicine, 2003
... bcl-2-immunoglobulin transgenic mice demonstrate extended B cell ...
Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways
Supplier
In Breast Cancer Research : BCR, 2002
... overnight incubation with mouse anti-Bag-1 IgG (Chemicon, Temecula, CA, USA) at 1:400 and with mouse anti-Bcl-2 IgG (Dako Corp., Carpinteria, CA, USA) ...
Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells.
Supplier
In PLoS ONE, 2002
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
Supplier
In The Journal of Cell Biology, 2002
... vav-bcl-2 transgenic mice (provided by J ...
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
Supplier
In The Journal of Experimental Medicine, 2002
... VavP-Bcl2 transgenic mice develop follicular lymphoma ...
B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice
Supplier
In The Journal of Experimental Medicine, 2001
... , Bcl2-22 transgenic (Bcl2 tg), Bcl2 ...
Topographic association of gastric epithelial expression of Ki-67, Bax, and Bcl-2 with antralization in the gastric incisura, body, and fundus
Supplier
In Gastroenterology Research and Practice, 2001
... calculation, four slides carrying two-sections each were immunohistochemically examined for the p53, Ki-67, Bax, and Bcl-2 expression (Biogenex Laboratories, Inc., San Ramon, ...
The nitric oxide donor NOC12 protects cultured astrocytes against apoptosis via a cGMP-dependent mechanism
Supplier
In Journal of Korean Medical Science, 2001
... Rabbit polyclonal antibodies against PARP, ICAD, Bax, AIF and mouse polyclonal antibody against Bcl-2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, U.S.A.) ...
Effect of intravenous bisphosphonates on release of basic fibroblast growth factor in serum of patients with cancer-associated hypercalcemia
Supplier
In British Journal of Cancer, 2001
... The mouse bax and bcl-2 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Supplier
In Virchows Archiv, 2001
... BCL2124Citrate1:25Dako ...
Design-based stereological methods for counting neurons
Supplier
In Molecular Neurodegeneration, 2001
... to reduce the possibility of effects of other genes co-segregating with the bcl-2 transgene, the Bcl-2 over-expressing transgenic mice were backcrossed to ...
Cdk5 phosphorylates p53 and regulates its activity.
Supplier
In PLoS ONE, 2001
... to β-actin, Tau, β tubulin III, RARα, RARβ, p-ERK p-JNK, p-p38, p21, caspase 3, Bax, Bcl-2 and HRP-labeled secondary anti-goat, anti-mouse, and anti-rabbit antibodies were all purchased from Santa Cruz Biotechnology (Santa Cruz, USA) ...
iNOS and nitrotyrosine expression after spinal cord injury
Supplier
In Naunyn-Schmiedeberg's Archives of Pharmacology, 2000
... ), or with anti-Bcl-2 polyclonal antibody (Santa Cruz Biotechnology, DBA, Milan, Italy) ...
Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes
Supplier
In BMC Cancer, 2000
... Anti-Bax, anti-Bcl-2, anti-cytochrome-c and secondary antibodies were from Santa Cruz Biotechnology (California, USA) ...
c-Myc Is a Critical Target for C/EBPα in Granulopoiesis.
Supplier
In PLoS ONE, 2000
... BCL-2 transgenic, and RAG-2 ...
Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim
Supplier
In The Journal of Experimental Medicine, 2000
... bcl-2 transgenic lines were used: ...
Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide
Supplier
In The Journal of Cell Biology, 2000
... Polyclonal anti-cleaved caspase 3 rabbit IgG, monoclonal anti-Bcl-2 mouse IgG, and monoclonal anti-phospho Bcl-2 antagonist of death mouse IgG were purchased from Cell Signaling.
A contribution to the diagnosis of the small dentigerous cyst or the paradental cyst
Supplier
In International Journal of Dentistry, 2000
... to the cell proliferation-associated antigen Ki-67 (Dako-Denmark) dilution 1 : 100, and monoclonal antibody to the oncoprotein bcl-2 (Novocastra-Leica, New CastleUK) dilution 1 : 100, ...
Deficiency of the stress kinase p38α results in embryonic lethalitycharacterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
Supplier
In The Journal of Experimental Medicine, 1999
... vav-bcl-2-68 and -69 transgenic mouse strains expressing a human ...
Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
Supplier
In The Journal of Experimental Medicine, 1999
... VavP-Bcl2 transgenic mice develop follicular lymphoma ...
NMR-based screening of proteins containing C-13-labeled methyl groups
Supplier
In PLoS Pathogens, 1999
... v-Bcl-2 transgenic mice were generated as ...
Caspase knockoutsmatters of life and death
Supplier
In The Journal of Cell Biology, 1998
... Bcl-xL/S polyclonal antibody and Bcl-2 monoclonal antibody were purchased from Santa Cruz Biotechnology, Inc ...
Effect of recombinant human erythropoietin on endothelial cell apoptosis
Supplier
In Korean Journal of Pediatrics, 1998
... Primary antibodies included the following: Bcl-2 (1:1,000; Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8α+ Dendritic Cells In Vivo
Supplier
In The Journal of Experimental Medicine, 1998
... Bcl-2 transgenic mice in the B6 ...
Cytolytic T lymphocyte-associated antigen-4 and the TcRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
Supplier
In PLoS ONE, 1998
... anti-phospho AKT (Thr-308) from New England Biolabs (Hertfordshire, UK), anti-BcL-XL from Cambridge Bioscience (Cambridge, UK), anti-BcL-2 from BD Biosciences (Oxford, UK) ...
Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone
Supplier
In BMC Cell Biology, 1998
... Specific antibodies against cyclin D and Bcl-2 were obtained from Santa Cruz Biotechnology, Inc ...
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cells
Supplier
In Virchows Archiv, 1998
... Apoptosis-related protein FasL with antibodies from Alexis Biochemicals, San Diego, CA, USA, Fas, Bax and Bcl-2 with antibodies from Santa Cruz Biotechnology, Santa Cruz, California, USA ...
Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells
Supplier
In The Journal of Experimental Medicine, 1998
... ) and Bcl-2 transgenic ( ...
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
Supplier
In British Journal of Cancer, 1997
The Bcl-2 protein family: arbiters of cell survival
Supplier
In International Journal of Medical Sciences, 1997
... Bcl-2 antibody was from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk
Supplier
In The Journal of Experimental Medicine, 1997
... Eμ–bcl-2 transgenic B6 ...
Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
Supplier
In The Journal of Cell Biology, 1997
... purchased from Oncogene Research Products, anti-avian-Src antibody from Upstate Biotechnology, anti-Golgi 58K antibody from Sigma-Aldrich, anti-Bcl-2 antibody from Santa Cruz Biotechnology, Inc., and anti-CoxI, -CoxII, ...
Expression of α-catenin in α-catenin–deficient cells increases resistance to sphingosine-induced apoptosis
Supplier
In The Journal of Cell Biology, 1997
An mAb against Bcl-2 was obtained from Santa Cruz Biotechnology, Inc ...
Injected cytochrome c induces apoptosis
Supplier
In The Journal of Cell Biology, 1997
... Rabbit pAb raised against amino acids 4–21 of human Bcl-2 was from Santa Cruz Biotechnology ...
Inhibition of HIV-1 infection by the beta-chemokine MDC
Supplier
In The Journal of Experimental Medicine, 1996
... RAG-2–deficient, bcl-2 transgenic pro B cells (R2BFL) and ...
Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of primary and committed T cells in EAU
Supplier
In The Journal of Experimental Medicine, 1996
... Bcl-2 transgenic mice expressing human Bcl-2 ...
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
Supplier
In Virus Research, 1996
... The spliced sequences encoding the mouse Bcl-2 alpha protein (locus AAA37282), the EMCV-IRES (pIRES2-EGFP; BD Clontech) and the 148 bp CR-IRES ...
A common inhibitory receptor for major histocompatability complex class I molecules on human lymphoid and myelomonocytic cells
Supplier
In The Journal of Experimental Medicine, 1996
... , Bar Harbor, ME) were mated with B6 MD4 Ig-transgenic mice and with bcl2-22–transgenic mice (22; more than ...
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
Supplier
In The Journal of Cell Biology, 1996
... mAb (19; Transduction), anti–caspase-7 mAb (4G2; MBL International Corporation), anti–β-actin mAb (C4; CHEMICON International Inc.), anti–Bcl-2 mAb (#100; BD Biosciences), Alexa 588–conjugated anti–mouse IgG ...
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
Supplier
In The Journal of Experimental Medicine, 1996
... ) mice and Eμ-bcl-2-36 transgenic mice, which express a human ...
The cyclin dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker
Supplier
In The Journal of Experimental Medicine, 1996
... p53 gene–deficient, Bcl-2 transgenic (Tg), DO.11.10 OVA TCR-α/β ...
Bcl-2 prevents nitric oxide-mediated apoptosis and poly(ADP-ribose) polymerase cleavage
Supplier
In Nucleic Acids Research, 1996
... The antibodies against Bcl-2 were from Upstate Biotechnology or Santa Cruz Biotechnology.
BCL11B is required for positive selection and survival of double-positive thymocytes
Supplier
In The Journal of Experimental Medicine, 1995
... Al Singer (NCI) for the BCL2 transgenic mice.
Molecular thanatopsis: a discourse on the BCL2 family and cell death
Supplier
In British Journal of Cancer, 1995
... (M-125, SC-7195) antibodies were purchased from Santa Cruz (Santa Cruz, CA, USA); anti-Bcl-2 antibody was from DAKO (Copenhagen, Denmark); anti-caspase-8 and ...
B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation.
Supplier
In PLoS ONE, 1995
... Bcl-2 transgenic mice ...
Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell–derived neural transplants
Supplier
In The Journal of Cell Biology, 1995
... nestin mouse monoclonal IgG (clone Rat 401), anti-desmin mouse monoclonal IgG (clone RD 301), and anti-Bcl-2 monoclonal mouse IgG (clone 7) were obtained from BD Biosciences.
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
Supplier
In British Journal of Cancer, 1994
... -Integrin was detected using CD29 antibody diluted 1 : 100 (Novocastra, Newcastle, UK), and Bcl-2 was detected using Clone 124 antibody diluted 1 : 200 (Dako, Glostrup, Denmark) ...
Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
Supplier
In International Journal of Nanomedicine, 1994
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Supplier
In Cell Death & Disease, 1994
... (1:200, sc-28226, Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-Bcl-xL (1:500, 610209, BD Transduction Laboratories), anti-Bcl-2 (1:200, sc-492, Santa Cruz Biotechnology), anti-p-eIF2 ...
Pharmacology of oleanolic acid and ursolic acid.
Supplier
In PLoS ONE, 1994
... Bcl-2 antibody (clone 124) was from DAKO (Carpinteria, CA, USA) and ...
Gelsolin displaces phalloidin from actin filaments. A new fluorescence method shows that both Ca2+ and Mg2+ affect the rate at which gelsolin severs F-actin
Supplier
In Cell research, 1993
... BCL2 cDNA (Accession: NM__00063, OriGene Technologies) into the Not ...
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors
Supplier
In The Journal of Experimental Medicine, 1991
... , mIgμ, and Bcl-2 transgenic strains have been previously ...
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 1990
Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
Supplier
In The Journal of Experimental Medicine, 1990
... Cytoplasmic staining with FITC-conjugated anti–Bcl-2 mAb (clone 124; DAKO A/S, Glostrup, Denmark) was ...
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
Supplier
In The Journal of Experimental Medicine, 1990
... -2-22 Bcl-2 transgenic mice ...
Electrophoresis transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
Supplier
In International Journal of Molecular Sciences, 1978
... Polyclonal antibodies against beta-actin, Tom-40, NF-κB, iNOS and Bcl-2 were purchased from Santa Cruz Biotechnology Inc ...
Methodologic studies of the quantitative microdetermination of ATP in biological materials with the firefly enzyme system.
Supplier
In PLoS ONE, 1966
... Anti BAD and anti Bcl-2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
