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BRCA2 and CDKN1A interacting protein

BCCIP, BCCIPalpha, BCCIPbeta, BRCA2 and CDKN1A interacting protein, Tok-1alpha
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p21, p53, Rad51, CAN, V1a
Papers on BCCIP
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53.
New
Pandey et al., Newark, United States. In J Virol, Aug 2015
We found that FBP1 promotes HCV replication by inhibiting p53 and regulating BCCIP and TCTP, which are positive and negative regulators of p53, respectively.
The beta-isoform of the BRCA2 and CDKN1A(p21)-interacting protein (BCCIP) stabilizes nuclear RPL23/uL14.
Kutay et al., Zürich, Switzerland. In Febs Lett, 2014
BRCA2 and CDKN1A(p21,CIP1)-interacting protein (BCCIP) is an evolutionary conserved protein implicated in maintenance of genome stability and cell cycle progression.
BCCIP suppresses tumor initiation but is required for tumor progression.
Shen et al., New Brunswick, United States. In Cancer Res, 2014
Using a BRCA2-interacting protein BCCIP as the platform, we found that a conditional BCCIP knockdown and concomitant p53 deletion caused rapid development of medulloblastomas, which bear a wide spectrum of alterations involving the Sonic Hedgehog (Shh) pathway, consistent with a caretaker responsibility of BCCIP on genomic integrity.
Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53.
Pandey et al., Newark, United States. In Bmc Cancer, 2013
METHODS: Western blotting was carried out to detect the expression level of FBP1, p21 and p53, and also p53 regulatory factors, BCCIP and TCTP; real-time quantitative PCR was done to determine the fold change in mRNA levels of target proteins; immunoprecipitation was carried out to determine the interaction of FBP1 with p53, BCCIP and TCTP.
Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues.
Jin et al., Changchun, China. In Int J Oncol, 2013
Human BCCIP, a protein which interacts with BRCA2 and CDKN1A (Cip1, p21), has been implicated in many cellular processes including cell cycle regulation, DNA recombination and damage repair, telomere maintenance, embryonic development and genomic stability.
Mutation analysis of the BCCIP gene for breast cancer susceptibility in breast/ovarian cancer families.
Diez et al., Barcelona, Spain. In Gynecol Oncol, 2013
The BCCIP gene plays an important role in the regulation of gene transcription and cell proliferation and could be involved in the maintenance of genomic integrity.
Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer.
Konecny et al., Los Angeles, United States. In Mol Cancer Ther, 2013
Low expression of other genes involved in homologous repair (e.g., BCCIP, BRCC3, ATM, RAD51L1), amplification of AURKA or EMSY, and response to platinum-based chemotherapy was associated with sensitivity to rucaparib.
17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration.
Lin et al., Québec, Canada. In Breast Cancer Res, 2011
17β-HSD1 regulates the expression of important genes and proteins that are relevant to cell growth control, such as BRCA2 and CDKN1A interacting protein (BCCIP) and proliferating cell nuclear antigen (PCNA) which are down- and upregulated in MCF7-17βHSD1 cells, respectively.
Requirement of mouse BCCIP for neural development and progenitor proliferation.
Shen et al., New Brunswick, United States. In Plos One, 2011
BCCIP is a BRCA2 and CDKN1A interacting protein implicated in HR and inhibition of DNA replication stress.
Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes.
Shen et al., New Brunswick, United States. In Plos Genet, 2011
BCCIP is a BRCA2- and CDKN1A(p21)-interacting protein that has been implicated in the maintenance of genomic integrity.
Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways.
Zhu et al., New Haven, United States. In Bmc Cancer, 2009
These included BCCIP (Q = 0.002), BCL2 (Q = 0.049), CCND1 (Q = 0.009), CDKN1A (Q < 0.001), GADD45A (Q = 0.002), HERC5 (Q < 0.001), MCM5 (Q = 0.042), PPP1R15A (Q < 0.001), SUMO1 (Q < 0.001), and UBA1 (Q = 0.023).
The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair.
Shen et al., New Brunswick, United States. In Cancer Res, 2009
Proximate to the COOH terminus of the BRCA2 protein, a conserved and DNA binding domain (BRCA2-DBD) interacts with filamin-A and BCCIP.
BCCIP is required for the nuclear localization of the p21 protein.
GeneRIF
Shen et al., New Brunswick, United States. In Cell Cycle, 2009
regulation of p21 intracellular distribution is a new mechanism for BCCIP to modulate p21 functions
Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin.
Hansen et al., Gainesville, United States. In J Cell Biochem, 2009
At 24 h, rOvUS decreased expression of 16 genes related to regulation and progression through M (BIRC5, CCNB1, CKS2, CDK5RAP1, CDC20, E2F4, MAD2L2) and G(1) (CDK4, CDKN3, TFDP2), DNA damage checkpoints and repair (RAD17, BRCA1, BCCIP, KPNA2, RAD1).
Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas.
GeneRIF
Shen et al., New Brunswick, United States. In Bmc Cancer, 2008
BCCIP protein expression was not detectable in approximately 45% of all astrocytic tumors.
BCCIP associates with the receptor protein tyrosine phosphatase PTPmu.
GeneRIF
Brady-Kalnay et al., Cleveland, United States. In J Cell Biochem, 2008
BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway.
LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells.
GeneRIF
Britt et al., Providence, United States. In Biochem Biophys Res Commun, 2008
LYRIC/AEG-1 is a negative regulator of BCCIPalpha, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NF-kappaB signaling pathway.
Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.
GeneRIF
Shen et al., Albuquerque, United States. In Cancer Res, 2008
BCCIP-dependent repair of double strand breaks by homologous recombination is an early RAD51 response to ionizing radiation-induced DNA damage.
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