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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

AT rich interactive domain 4B

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, CAN, HAD, Serum albumin
Papers on BCAA
Overexpression of the pleiotropic regulator CodY decreases sporulation, attachment and pellicle formation in Bacillus anthracis.
Bhatnagar et al., New Delhi, India. In Biochem Biophys Res Commun, Feb 2016
It is activated by metabolic effectors like BCAA and GTP.
Living related versus deceased donor liver transplantation for maple syrup urine disease.
Strauss et al., São Paulo, Brazil. In Mol Genet Metab, Feb 2016
Mutant heterozygous liver segments effectively maintain steady-state BCAA and BCKA homeostasis on an unrestricted diet and during most catabolic states, but might have different metabolic effects than grafts from unrelated deceased donors.
System-L amino acid transporters play a key role in pancreatic β-cell signalling and function.
Herbert et al., Australia. In J Mol Endocrinol, Jan 2016
UNASSIGNED: The branched-chain amino acids (BCAA) leucine, isoleucine and valine, are essential amino acids that play a critical role in cellular signalling and metabolism.
A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids.
Walford et al., Boston, United States. In Food Nutr Res, Dec 2015
Fasting BCAA levels are influenced by non-dietary factors.
Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation.
Burant et al., Ann Arbor, United States. In Cell Metab, Apr 2015
Our data suggest that efficient FA and BCAA utilization contribute to high intrinsic exercise capacity and the health and longevity benefits associated with enhanced fitness.
Ammonia and amino acid profiles in liver cirrhosis: effects of variables leading to hepatic encephalopathy.
Holecek, Hradec Králové, Czech Republic. In Nutrition, 2015
Branched-chain amino acids (BCAA; valine, leucine, and isoleucine) decrease due to activated GLN synthesis in muscle.
Evaluation of congruence among dietary supplement use and motivation for supplementation in young, Canadian athletes.
Erdman et al., Calgary, Canada. In J Int Soc Sports Nutr, 2014
Branched chain amino acids (BCAA) and glutamine were linked to improving diet and immune function (p < 0.01), but were more strongly associated with performance reasons, as were performance foods (protein powder, sport bars, sport gels, etc.).
Nutritional and regulatory roles of leucine in muscle growth and fat reduction.
Yin et al., Key West, United States. In Front Biosci, 2014
The metabolic roles for L-leucine, an essential branched-chain amino acid (BCAA), go far beyond serving exclusively as a building block for de novo protein synthesis.
Branched-chain amino acids in metabolic signalling and insulin resistance.
Adams et al., United States. In Nat Rev Endocrinol, 2014
A BCAA dysmetabolism model proposes that the accumulation of mitotoxic metabolites (and not BCAAs per se) promotes β-cell mitochondrial dysfunction, stress signalling and apoptosis associated with T2DM.
The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus.
Melnik, Osnabrück, Germany. In Curr Diabetes Rev, 2014
MicroRNA-29b downregulates branchedchain α-ketoacid dehydrogenase, a potential explanation for increased BCAA serum levels, the metabolic signature of insulin resistance and type 2 diabetes mellitus (T2DM).
Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.
Buettner et al., New York City, United States. In Cell Metab, 2014
Circulating branched-chain amino acid (BCAA) levels are elevated in obesity/diabetes and are a sensitive predictor for type 2 diabetes.
Effects of dairy protein and fat on the metabolic syndrome and type 2 diabetes.
Hermansen et al., Århus, Denmark. In Rev Diabet Stud, 2013
It has been confirmed by observations that the insulinotropic effect of dairy proteins is associated with the amino acid composition; in particular branched-chain amino acids (BCAA) seem to be of vital importance.
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.
Radlwimmer et al., Heidelberg, Germany. In Nat Med, 2013
These findings suggest a central role for BCAT1 in glioma pathogenesis, making BCAT1 and BCAA metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.
Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.
Hunter et al., Bethesda, United States. In Plos Genet, 2012
These studies support a causative role of ARID4B in metastatic progression of breast cancer.
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice.
Nisoli et al., Pavia, Italy. In Cell Metab, 2010
Here, we show that a BCAA-enriched mixture (BCAAem) increased the average life span of mice.
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Svetkey et al., Durham, United States. In Cell Metab, 2009
Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance.
Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.
Beaudet et al., Houston, United States. In J Natl Cancer Inst, 2008
10 of 12 Arid4a(-/-)Arid4b(+/-) mice progressed to acute myeloid leukemia (AML) and had rapid further increases of leukocyte counts.
Characterization of BRCAA1 and its novel antigen epitope identification.
Sarai et al., Stuttgart, Germany. In Cancer Epidemiol Biomarkers Prev, 2004
Immunohistochemistry analysis showed that the antigen epitope exhibited positive expression in 65% (39 of 60) breast cancer specimens and negative expression in 60 non-cancerous tissues. A novel breast cancer antigen epitope, SSKKQKRSHK, is identified
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