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Charged multivesicular body protein 2A

CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, SET, Tenascin
Papers on BC2
Recognition of human telomeric G-quadruplex DNA by berberine analogs: effect of substitution at the 9 and 13 positions of the isoquinoline moiety.
Suresh Kumar et al., Calcutta, India. In J Mol Recognit, Dec 2015
9-ω-amino hexyl ether analog (BC1) showed highest affinity (1.8 × 10(6)  M(-1) ) while the affinity of the 13-phenylpropyl analog (BC2) was 1.09 × 10(6)  M(-1) .
The genetic architecture of leaf number and its genetic relationship to flowering time in maize.
Tian et al., Beijing, China. In New Phytol, Dec 2015
Here, using a large set of 866 maize-teosinte BC2 S3 recombinant inbred lines genotyped by using 19 838 single nucleotide polymorphism markers, we conducted a comprehensive genetic dissection to assess the genetic architecture of leaf number and its genetic relationship to flowering time.
Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine treatment and radiotherapy.
Fernö et al., Lund, Sweden. In Eur J Cancer, Nov 2015
We hereby investigate phenotypical and prognostic features of the second tumour (BC2) in relation to prior endocrine treatment and radiotherapy.
Bean common mosaic virus Isolate Exhibits a Novel Pathogenicity Profile in Common Bean, Overcoming the bc-3 Resistance Allele Coding for the Mutated eIF4E Translation Initiation Factor.
Karasev et al., Moscow, Russia. In Phytopathology, Nov 2015
Here, we characterized a novel BCMV isolate 1755a that was able to overcome bc-2 and bc-3 alleles in common bean.
ESCRT-III controls nuclear envelope reformation.
Carlton et al., Bristol, United Kingdom. In Nature, Jul 2015
The ESCRT-III component charged multivesicular body protein 2A (CHMP2A) is directed to the forming NE through binding to CHMP4B, and provides an activity essential for NE reformation.
Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity.
Vitali et al., Bologna, Italy. In Plos One, 2014
In particular, L. crispatus BC2, L. gasseri BC10 and L. gasseri BC11 appeared to be the most active strains in reducing pathogen adhesion, as their effects were mediated by both cells and supernatants.
Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing.
Gruvberger-Saal et al., Lund, Sweden. In Breast Cancer Res, 2014
Although there have been indications that the second tumor (BC2) sometimes may represent a metastatic spread of BC1, this has never been conclusively shown.
Characterization of Chromosome Inheritance of the Intergeneric BC2 and BC3 Progeny between Saccharum spp. and Erianthus arundinaceus.
Zhang et al., Fuzhou, China. In Plos One, 2014
To investigate the introgression of the E. arundinaceus genome into sugarcane in the higher generations, intergeneric BC2 and BC3 progeny generated between Saccharum spp.
The Orthology Clause in the Next Generation Sequencing Era: Novel Reference Genes Identified by RNA-seq in Humans Improve Normalization of Neonatal Equine Ovary RT-qPCR Data.
Steinborn et al., Vienna, Austria. In Plos One, 2014
The expression stability of eleven novel RGs (C1orf43, CHMP2A, EMC7, GPI, PSMB2, PSMB4, RAB7A, REEP5, SNRPD3, VCP and VPS29) was assessed by RT-qPCR in ovaries of seven neonatal fillies and compared to that of the expressed repetitive element ERE-B, two universal (OAZ1 and RPS29) and four traditional RGs (ACTB, GAPDH, UBB and B2M).
Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits.
Lippincott-Schwartz et al., Bethesda, United States. In Science, 2014
We observed ESCRT subunits localized within the head of budding virions and released particles, with head-localized levels of CHMP2A decreasing relative to Tsg101 and CHMP4B upon virus abscission.
γ2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits.
Prange et al., Mainz, Germany. In Biochim Biophys Acta, 2010
Data show that gamma2-adaptin in MVB sorting specifically interacts with the ESCRT subunits Vps28 and CHMP2A.
Structure and function of ESCRT-III.
Weissenhorn et al., Grenoble, France. In Biochem Soc Trans, 2009
At least CHMP (charged multivesicular body protein) 2A and CHMP3 assemble into helical tubular structures that provide a platform for membrane interaction and VPS (vacuolar protein sorting) 4-catalysed effects leading to disassembly of ESCRT-III CHMP2A-CHMP3 polymers in vitro.
Helical structures of ESCRT-III are disassembled by VPS4.
Weissenhorn et al., Grenoble, France. In Science, 2008
study found the ESCRT-III proteins CHMP2A & CHMP3 could assemble in vitro into helical tubular structures that expose their membrane interaction sites on the outside of the tubule; VPS4 could bind on the inside of the tubule & disassemble the tubes
Alien introgression in rice.
Khush et al., Manila, Philippines. In Plant Mol Biol, 1997
The rapid recovery of recurrent phenotypes in BC2 and BC3 generations from wide crosses is an indication of limited recombination.
Control of neuronal gene expression.
Reynolds et al., In Science, 1984
The identifier sequences are transcribed by RNA polymerase III exclusively in neurons to produce two RNA species, BC1 and BC2, of 160 and 100 to 110 nucleotides.
Identifier sequences are transcribed specifically in brain.
Lerner et al., In Nature, 1984
An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo exclusively in neural tissues.
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