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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

BCL6 corepressor

BC or
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: HAD, CAN, bcl-6, AGE, ACID
Papers on BC or
Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type.
New
Takeuchi et al., Tokyo, Japan. In Genes Chromosomes Cancer, Feb 2016
We identified several recurrent somatic mutations involving BCOR (32%), TP53 (16%), DDX3X (12%), FAT4 (8%), NRAS (8%), MLL3 (12%) and MIR17HG (8%).
Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas.
New
Antonescu et al., Birmingham, United Kingdom. In Am J Surg Pathol, Feb 2016
About two-thirds of EWSR1-negative SBRCTs are associated with CIC-DUX4-related fusions, whereas another small subset shows BCOR-CCNB3 X-chromosomal paracentric inversion.
Myelodysplastic syndromes: Contemporary review and how we treat.
Review
New
Tefferi et al., Rochester, United States. In Am J Hematol, Jan 2016
With the advent of next generation sequencing, recurrent somatic mutations in genes involved in epigenetic regulation (TET2, ASXL1, EZH2, DNMT3A, IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1, ZRSR2), DNA damage response (TP53), transcriptional regulation (RUNX1, BCOR, ETV6) and signal transduction (CBL, NRAS, JAK2) have been identified in MDS.
Identification of the BRAF V600E mutation in gastroenteropancreatic neuroendocrine tumors.
New
Kim et al., Seoul, South Korea. In Oncotarget, Jan 2016
Among 12 GEP-NETs, eight showed mutations of more than one cancer-related gene, including TP53, CNBD1, RB1, APC, BCOR, BRAF, CTNNB1, EGFR, EP300, ERBB3, KDM6A, KRAS, MGA, MLL3, PTEN, RASA1, SMARCB1, SPEN, TBC1D12, and VHL.
Ossifying fibromyxoid tumor: morphology, genetics, and differential diagnosis.
Review
New
Thway et al., London, United Kingdom. In Ann Diagn Pathol, Jan 2016
It is now established that OFMTs represent translocation-associated tumors, with up to 85% associated with recurrent gene rearrangements, mostly involving the PHF1 gene (including in typical, atypical, and malignant neoplasms), with EP400-PHF1 in approximately 40% of tumors, and ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions also described.
Contemporary Occupational Carcinogen Exposure and Bladder Cancer: A Systematic Review and Meta-analysis.
Review
New
Catto et al., Sheffield, United Kingdom. In Jama Oncol, Jan 2016
We excluded reports in which BC or occupation were not the main focus, and those with insufficient case, risk, or confidence interval data.
Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.
New
Impact
Kiyokawa et al., Tokyo, Japan. In Nat Genet, Aug 2015
We identified internal tandem duplications in the BCOR gene (BCL6 corepressor) affecting the C terminus in 100% (20/20) of CCSK tumors but in none (0/193) of the other pediatric renal tumors.
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
Cagney et al., Dublin, Ireland. In Sci Rep, 2014
PCGF1 is a component of a variant PRC1 complex that also contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B.
Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations.
Review
Fukayama et al., Tokyo, Japan. In Pathobiology, 2014
In addition to having the highest level of DNA methylation in CpG islands of promoter regions, EBVaGC harbors particular gene alterations, including a high frequency of mutations in PIK3CA and ARID1A, mutation in BCOR, and amplification of PD-L1 and PD-L2.
High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review.
Review
Kraut et al., Southfield, United States. In Am J Case Rep, 2014
BACKGROUND: A subset of undifferentiated small round cell sarcomas (USRCSs) is currently being recognized as emerging entities with unique gene fusions: CIC-DUX4 (the area of focus in this article), BCOR-CCNB3, or CIC-FOXO4 gene fusions.
AGER genetic polymorphisms increase risks of breast and lung cancers.
Liu et al., Jinzhou, China. In Genet Mol Res, 2014
An increased frequency of the AGER rs1800625 T>C polymorphism was observed in patients with either BC or LC.
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Impact
Cho et al., Cambridge, United States. In Nature, 2012
Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.
A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion.
Impact
GeneRIF
Delattre et al., Paris, France. In Nat Genet, 2012
A new fusion was observed between BCOR (encoding the BCL6 co-repressor) and CCNB3 (encoding the testis-specific cyclin B3) on the X chromosome.
A family of oculofaciocardiodental syndrome (OFCD) with a novel BCOR mutation and genomic rearrangements involving NHS.
GeneRIF
Matsumoto et al., Yokohama, Japan. In J Hum Genet, 2012
the mutation in BCOR is likely to be the major determinant for the phenotypes in this Oculofaciocardiodental syndrome (OFCD) family.
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype.
GeneRIF
Falini et al., M√ľnchen, Germany. In Blood, 2012
Our results for the first time implicate BCOR in normal karyotype acute myeloid leukemia pathogenesis.
BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.
GeneRIF
Emi et al., Japan. In Blood, 2010
BCOR is a fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. BCOR-RARA possesses common features with other RARA fusion proteins.
BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.
Impact
GeneRIF
Wang et al., Los Angeles, United States. In Nat Cell Biol, 2009
Data show that AP-2alpha was identified as a repressive target of BCOR, and BCOR mutation resulted in abnormal activation of AP-2alpha.
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