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Ribosomal protein L13

BBC1, mti1, RPL13
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: GAPDH, Actin, SET, CAN, L13
Papers on BBC1
Phloem-specific methionine recycling fuels polyamine biosynthesis in a sulfur-dependent manner and promotes flower and seed development.
New
Pommerrenig et al., Erlangen, Germany. In Plant Physiol, Jan 2016
We analyzed Arabidopsis thaliana mutants with defects in the Met Cycle enzymes 5-METHYLTHIORIBOSE-1-PHOSPHATE-ISOMERASE1 (MTI1) and DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1 (DEP1) under different S conditions and assayed the contribution of the Met Cycle to the regeneration of S for these pathways.
Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.
New
Ito et al., Hirosaki, Japan. In Br J Haematol, Mar 2015
Additional novel mutations were found in eight patients, including RPL3L, RPL6, RPL7L1T, RPL8, RPL13, RPL14, RPL18A and RPL31.
Identification and validation of reference genes for normalization of gene expression analysis using qRT-PCR in Helicoverpa armigera (Lepidoptera: Noctuidae).
New
Liu et al., Beijing, China. In Gene, Feb 2015
Results showed that the most suitable candidate combinations of reference genes were as follows: 28S and RPS15 for developmental stages; RPS15 and RPL13 for larvae tissues; EF and RPL27 for adult tissues; GAPDH, RPL27, and β-TUB for nuclear polyhedrosis virus infection; RPS15 and RPL32 for insecticide treatment; RPS15 and RPL27 for temperature treatment; and RPL32, RPS15, and RPL27 for all samples.
Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma.
Kmiec et al., Gdańsk, Poland. In Tumour Biol, 2014
RPL13 gene was the most stable RG in analysis of 35 primary tumor nonmetastatic versus 35 mccRCC samples and matched metastasized T/C/M samples (n = 12, each group).
Stably expressed housekeeping genes across developmental stages in the two-spotted spider mite, Tetranychus urticae.
Zhou et al., Changsha, China. In Plos One, 2014
In this study, ten housekeeping genes, including beta-actin (Actin) , elongation factor 1 α (EF1A) , glyceralde hyde-3-phosphate dehydrogenase (GAPDH) , ribosomal protein L13 (RPL13) , ribosomal protein 49 (RP49) , α-tubulin (Tubulin) , vacuolar-type H+-ATPase (v-ATPase) , succinate dehydrogenase subunit A (SDHA) , 28S ribosomal RNA (28S) , and 18S ribosomal RNA (18S) from the two-spotted spider mite, Tetranychus urticae, were selected as the candidate reference genes.
The epigenetic landscape of Alzheimer's disease.
Cruchaga et al., Saint Louis, United States. In Nat Neurosci, 2014
Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease.
Growth inhibitory effects of large subunit ribosomal proteins in melanoma.
Robertson et al., United States. In Pigment Cell Melanoma Res, 2014
RPL13 represents the second category, where siRNA-mediated targeting inhibited tumor development through decreased cellular proliferation.
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
Bennett et al., Boston, United States. In Nat Neurosci, 2014
Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2.
The Machinery of Authoritarian Care: Dramatising Breast Cancer Treatment in 1970s Britain.
Toon, In Soc Hist Med, 2014
This article examines the professional and public response to the television play Through the Night, which aired on BBC1 in December 1975.
Excitation energies with linear response density matrix functional theory along the dissociation coordinate of an electron-pair bond in N-electron systems.
Baerends et al., Amsterdam, Netherlands. In J Chem Phys, 2014
With the example of an elementary primitive NO functional (BBC1) it is shown that current density matrix functional theory ground state functionals, which were designed to produce decent approximations to the total energy, fail to deliver a qualitatively correct structure of the (inverse) response function, due to essential deficiencies in the reconstruction of the two-body reduced density matrix (2RDM).
Time-dependent expression of SNAT2 mRNA in the contused skeletal muscle of rats: a possible marker for wound age estimation.
Wang et al., Taiyuan, China. In Forensic Sci Med Pathol, 2013
Sequence-specific primers and TaqMan fluorogenic probes for SNAT2 mRNA and RPL13 mRNA were designed using the AlleleID 6 software, and the expression levels of SNAT2 mRNA were determined by real-time PCR.
Selection of reference genes for quantitative real-time PCR normalization in Panax ginseng at different stages of growth and in different organs.
Zhao et al., Changchun, China. In Plos One, 2013
GAPDH/30S RPS20, CYP/60S RPL13 and CYP/QCR were the optimum pair of reference genes in the roots, stems, and leaves.
Validation of suitable reference genes for expression normalization in Echinococcus spp. larval stages.
Zaha et al., Rio Grande, Brazil. In Plos One, 2013
The gene expression stability of eleven candidate reference genes (βTUB, NDUFV2, RPL13, TBP, CYP-1, RPII, EF-1α, βACT-1, GAPDH, ETIF4A-III and MAPK3) was assessed using geNorm, Normfinder, and RefFinder.
Reference genes for quantitative gene expression studies in multiple avian species.
Gruber et al., Berlin, Germany. In Plos One, 2013
Here we report testing a set for 14 candidate reference genes (18S, ABL, GAPDH, GUSB, HMBS, HPRT, PGK1, RPL13, RPL19, RPS7, SDHA, TFRC, VIM, YWHAZ) on different tissues of the mallard (Anas platyrhynchos), domestic chicken (Gallus gallus domesticus), common crane (Grus grus), white-tailed eagle (Haliaeetus albicilla), domestic turkey (Meleagris gallopavo f. domestica), cockatiel (Nymphicus hollandicus), Humboldt penguin (Sphenicus humboldti), ostrich (Struthio camelus) and zebra finch (Taeniopygia guttata), spanning a broad range of the phylogenetic tree of birds.
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
GeneRIF
Dias-Neto et al., São Paulo, Brazil. In J Neural Transm, 2009
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.
GeneRIF
Shinomura et al., Sapporo, Japan. In Int J Mol Med, 2006
Ribosomal protein L13 plays an essential role in the progression of some gastrointestinal malignancies.
Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress.
GeneRIF
de la Torre-Ruiz et al., Lleida, Spain. In J Biol Chem, 2005
Mtl1 is characterized for as a cell-wall sensor of oxidative stress.
Systematic genetic analysis with ordered arrays of yeast deletion mutants.
Impact
Boone et al., Toronto, Canada. In Science, 2002
SGA analysis of genes with roles in cytoskeletal organization (BNI1, ARP2, ARC40, BIM1), DNA synthesis and repair (SGS1, RAD27), or uncharacterized functions (BBC1, NBP2) generated a network of 291 interactions among 204 genes.
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