Hematopoietic stem cell injury induced by ionizing radiation.
Little Rock, United States. In Antioxid Redox Signal, 2014
The mechanisms include (i) induction of HSC apoptosis via the p53-Puma pathway; (ii) promotion of HSC differentiation via the activation of the G-CSF/Stat3/BATF-dependent differentiation checkpoint; (iii) induction of HSC senescence via the ROS-p38 pathway; and (iv) damage to the HSC niche.
Transcriptional control of dendritic cell development.
Saint Louis, United States. In Adv Immunol, 2012
Currently, the basis for DC development into the recognized subsets/lineages is only partially understood, based on the requirements for several transcription factors including PU.1, Bcl11a, Irf8, E2-2, Id2, Irf4, Irf8, Batf3, and other BATF family members.
Molecular signatures of T-cell inhibition in HIV-1 infection.
Linköping, Sweden. In Retrovirology, 2012
We also highlight the ensemble of transcriptional factors such as BATF, BLIMP-1/PRDM1, FoxP3, DTX1 and molecular pathways that facilitate the recruitment and differentiation of suppressor T cells in response to HIV infection.