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Basonuclin 1

basonuclin, BNC, basonuclin 1
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on basonuclin
BNC1 is required for maintaining mouse spermatogenesis.
GeneRIF
Tseng et al., Philadelphia, United States. In Genesis, 2012
BNC1 is required for the maintenance of spermatogenesis.
p63 Transcriptionally regulates BNC1, a Pol I and Pol II transcription factor that regulates ribosomal biogenesis and epithelial differentiation.
GeneRIF
Nylander et al., UmeƄ, Sweden. In Eur J Cancer, 2012
p63 induces the expression of the basal epithelial transcription factor, Basonuclin 1.
Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.
GeneRIF
Tseng et al., Philadelphia, United States. In Plos One, 2006
Basonuclin likely coordinates functions of a subset of ribosomal RNA genes (rDNA) and a group of protein coding genes in cellular processes critical for the regulation of cell proliferation
Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.
GeneRIF
Djian et al., Paris, France. In Proc Natl Acad Sci U S A, 2006
Data show that basonuclin (Bn)2 but not bn1 colocalizes with SC35 in nuclear speckles, and may have a function in nuclear processing of mRNA.
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