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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BarH-like homeobox 2

Barx2, Barx2b
This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, RGS, beta 2-adrenoceptor, SMG, Chordin
Papers on Barx2
Low expression of BARX2 in human primary hepatocellular carcinoma correlates with metastasis and predicts poor prognosis.
Zhu et al., Guangzhou, China. In Hepatol Res, 2015
AIM: The homeobox gene Barx2 was recently identified as a regulator of ovarian and breast cancer; however, the expression level of BARX2 and its significance in hepatocellular carcinoma (HCC) remain unknown.
The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea.
Zacharias et al., Ann Arbor, United States. In Dev Dyn, 2014
Finally, the cellular expression patterns of FOXC2, PITX1, and BARX2 in Pitx2 and Dkk2 mutants suggest that these transcription factors may be involved in specifying cell fate and establishing angiogenic privilege within the corneal mesenchyme.
Barx2 is expressed in satellite cells and is required for normal muscle growth and regeneration.
Makarenkova et al., Australia. In Stem Cells, 2012
Barx2 is an important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation.
Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling.
Makarenkova et al., San Diego, United States. In Development, 2011
data suggest a functional network involving Barx2, Fgf10 and matrix metalloproteinases that plays an essential role in regulating branching morphogenesis of the ocular glands.
The homeobox transcription factor Barx2 regulates plasticity of young primary myofibers.
Makarenkova et al., Los Angeles, United States. In Plos One, 2009
Study show that Barx2 regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation.
Barx2 controls myoblast fusion and promotes MyoD-mediated activation of the smooth muscle alpha-actin gene.
Meech et al., Los Angeles, United States. In J Biol Chem, 2009
Barx2 cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation.
Immunohistochemical localization of barx2 in the developing fetal mouse submandibular glands.
Yokose et al., Kōriyama, Japan. In Acta Histochem Cytochem, 2009
The Barx2 containing Homeobox exerts several key roles in development.
barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches.
Dawid et al., Bethesda, United States. In Dev Biol, 2008
Barx1 is expressed in the rhombencephalic neural crest, the pharyngeal arches, the pectoral fin buds and the gut in contrast to its paralogue barx2, which is most prominently expressed in the arch epithelium.
BARX2 and estrogen receptor-alpha (ESR1) coordinately regulate the production of alternatively spliced ESR1 isoforms and control breast cancer cell growth and invasion.
Meech et al., Los Angeles, United States. In Oncogene, 2006
BARX2 and estrogen receptor alpha may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression.
Identification of novel binding elements and gene targets for the homeodomain protein BARX2.
Meech et al., Los Angeles, United States. In J Biol Chem, 2004
BARX2 can coordinate the expression of a network of genes that influence the growth of tumor cells
Expression of the homeobox gene barx2 in the gut.
Powell et al., Adelaide, Australia. In J Histochem Cytochem, 2004
Barx2 is a member of the Bar class of homeobox genes and has been shown to regulate specific cell adhesion molecules, L1, Ng-CAM, N-CAM, and cadherin 6.
The homeobox gene BARX2 can modulate cisplatin sensitivity in human epithelial ovarian cancer.
Gabra et al., Edinburgh, United Kingdom. In Int J Oncol, 2002
The human homeobox gene BARX2 is located within a minimal region at 11q25 that is associated with frequent loss of heterozygosity (LOH) and adverse survival in EOC.
BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression.
Gabra et al., Edinburgh, United Kingdom. In Cancer Res, 2001
The human homeobox BARX2 is located at 11q24-q25, within a minimal region associated with frequent loss of heterozygosity and adverse survival in epithelial ovarian cancer.
Identification of Barx2b, a serum response factor-associated homeodomain protein.
Hoggatt et al., Indianapolis, United States. In J Biol Chem, 2001
A novel homeodomain-containing transcription factor, called Barx2b, was identified that specifically interacts with SRF and promotes the DNA binding activity of SRF.
Cloning and chromosomal localization of the human BARX2 homeobox protein gene.
Nelkin et al., Baltimore, United States. In Gene, 2000
The human BARX2 gene encodes a homeodomain-containing protein of 254 amino acids, which binds optimally to the DNA consensus sequence YYTAATGRTTTTY.
The human BARX2 gene: genomic structure, chromosomal localization, and single nucleotide polymorphisms.
Murray et al., Iowa City, United States. In Genomics, 2000
In this report, we present the genomic structure, chromosomal localization, and polymorphic markers in BARX2.
Chick Barx2b, a marker for myogenic cells also expressed in branchial arches and neural structures.
Tabin et al., Boston, United States. In Mech Dev, 1999
We have isolated a new chicken gene, cBarx2b, which is related to mBarx2 in sequence, although the expression patterns of the two genes are quite different from one another.
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