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BarH-like homeobox 1

Barx1
This gene encodes a member of the Bar subclass of homeobox transcription factors. Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GDF5, Foxf1, mTORC1, FOXP1, BMP4
Papers on Barx1
Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma.
New
Schumacher et al., Bonn, Germany. In Cancer Med, Nov 2015
They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1.
Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.
New
Shivdasani et al., Boston, United States. In Dev Biol, Oct 2015
Diverse functions of the homeodomain transcription factor BARX1 include Wnt-dependent, non-cell autonomous specification of the stomach epithelium, tracheo-bronchial septation, and Wnt-independent expansion of the spleen primordium.
A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson's Disease in the Han Population of Chinese Mainland.
New
Xu et al., Nanchang, China. In Mol Neurobiol, Aug 2015
We revealed that among the 22 potential loci implicated, PRDM2/KIAA1026 (kgp8090149), TSG1/MANEA (kgp154172), PDE10A (kgp8130520), MDGA2 (rs9323124), ATPBD4/LOC100288892 (kgp11333367), ZFP64/TSHZ2 (kgp4156164), PAQR3/ARD1B (kgp9482779), FLJ23172/FNDC3B (kgp760898), C18orf1 (kgp348599), FLJ43860/NCRNA00051 (kgp4105983), CYP1B1/C2orf58 (kgp11353523), WNT9A/LOC728728 (rs849898), ANXA1/LOC100130911 (rs10746953), FLJ35379/LOC100132423 (kgp9550589), PLEKHN1 (kgp7172368), DMRT2/SMARCA2 (kgp10769919), ZNF396/INO80C (rs1362858), C3orf67/LOC339902 (rs6783485), LOC285194/IGSF11 (rs1879553), FGF10/MRPS30 (rs13153459), BARX1/PTPDC1 (kgp6542803), and COL5 A2 (rs11186), the peak significance was at the kgp4105983 of FLJ43860 gene in chromosome 8, the first top strongest associated locus with sPD was PRDM2 (kgp8090149) in chromosome 1, and the 24 pathways including 100 significantly associated genes were strongly associated with sPD from HPCM.
Gene-expression analysis of cementoblasts and osteoblasts.
New
Kalajzic et al., Farmington, United States. In J Periodontal Res, Aug 2015
In addition, the transcription factor BARX homeobox 1 (Barx1) was expressed at higher levels in cementoblasts, and immunohistochemistry indicated that BARX1 was expressed in apical cementoblasts and cementocytes, but not in osteoblasts or odontoblasts.
Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
New
Jankowski et al., Rotterdam, Netherlands. In Gastroenterology, Feb 2015
Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1.
A gene expression map of the larval Xenopus laevis head reveals developmental changes underlying the evolution of new skeletal elements.
New
Medeiros et al., Boulder, United States. In Dev Biol, Feb 2015
In the first pharyngeal arch we observed a shift in the expression of the joint inhibitor barx1, and new expression of the joint marker gdf5, shortly before skeletal differentiation.
Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma.
Dinjens et al., Rotterdam, Netherlands. In J Carcinog, 2014
OBJECTIVE: Recently, single nucleotide polymorphisms (SNPs) associated with esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) were identified; rs10419226 (CRTC1), rs11789015 (BARX1), rs2687201 (FOXP1), rs2178146 (FOXF1), rs3111601 (FOXF1), and rs9936833 (FOXF1).
Genome-wide analysis of gene expression in human embryonic tooth germ.
Zhang et al., Fuzhou, China. In J Mol Histol, 2014
Moreover, in situ hybridization assay demonstrated tooth type specific expression of ISL1 and BARX1 in the incisor, canine, and molar respectively, consistent with microarray results.
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
Impact
Vaughan et al., Seattle, United States. In Nat Genet, 2013
A second is at 9q22 (rs11789015: P = 1.0 × 10(-9)) in BARX1, which encodes a transcription factor important in esophageal specification.
Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development.
Muller et al., Liège, Belgium. In Differentiation, 2013
Depletion of any of these two receptors by microinjection of antisense morpholinos results in severe defects in cartilage formation at 4 dpf and a decrease in expression of the late chondrocyte markers barx1 and runx2b.
barx1 represses joints and promotes cartilage in the craniofacial skeleton.
Kimmel et al., Eugene, United States. In Development, 2013
Genetic manipulation experiments in zebrafish demonstrate that functional loss, or gain, of the homeobox-containing gene barx1 produces gain, or loss, of joints, respectively.
Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates.
West et al., Alameda, United States. In Regen Med, 2013
RESULTS: In the undifferentiated progenitor state, each line displayed unique combinations of site-specific markers, including AJAP1, ALDH1A2, BMP5, BARX1, HAND2, HOXB2, LHX1, LHX8, PITX1, TBX15 and ZIC2, but none of the lines expressed the MSC marker CD74.
Redundant roles of PRDM family members in zebrafish craniofacial development.
Artinger et al., Aurora, United States. In Dev Dyn, 2013
Knockdown of prdm3 and prdm16 results in a reduction in the neural crest markers dlx2a and barx1 and defects in both the viscerocranium and the neurocranium.
Regulation of mouse stomach development and Barx1 expression by specific microRNAs.
GeneRIF
Shivdasani et al., Boston, United States. In Development, 2011
miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1.
Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation.
GeneRIF
Shivdasani et al., Boston, United States. In Plos One, 2010
Barx1 control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt pathway activity
Hoxa2 plays a direct role in murine palate development.
GeneRIF
Nazarali et al., Saskatoon, Canada. In Dev Dyn, 2009
Hoxa2 also repressed the expression of its downstream targets Barx1 within the palate.
barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches.
GeneRIF
Dawid et al., Bethesda, United States. In Dev Biol, 2008
These results indicate an essential role for barx1 at early stages of chondrogenesis within the developing zebrafish viscerocranium.
Barx1, growth factors and apoptosis in facial tissue of children with clefts.
GeneRIF
Akota et al., Rīga, Latvia. In Stomatologija, 2007
Regional expression of barx1 was observed in epithelium before mixed dentition, while during mixed dentition gene appeared in hyaline cartilage. Expression of barx1 appears in cleft lip palate affected structures mainly in mixed dentition.
Development of articular cartilage: what do we know about it and how may it occur?
Review
Gentili et al., Philadelphia, United States. In Connect Tissue Res, 1999
These factors include: the homeobox gene Barx-1; the bone morphogenetic protein (BMP) family member GDF-5; the growth factors HGF and PTHrP; and the transcription factor ERG. We summarize current thinking on how these factors participate in joint development and how some of these factors may influence development and behavior of epiphyseal chondrocytes.
Transformation of tooth type induced by inhibition of BMP signaling.
Impact
Sharpe et al., London, United Kingdom. In Science, 1998
BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10.
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