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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

BarH-like 1

Barhl1, BarH2, BarH-like, Mbh2
has similarity to D. melanogastar homeotic protein BarH2 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: BarH1, beta 2-adrenoceptor, Math1, HAIR, FATE
Papers on Barhl1
Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development.
Fritzsch et al., Iowa City, United States. In Development, Sep 2015
Replacement of Atoh1 with Neurog1 maintains limited expression of Pou4f3 and Barhl1 and rescues HCs quantitatively, but not qualitatively.
Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3.
Durand et al., New York City, United States. In Genesis, Feb 2015
The BarH-like (Barhl) proteins are homeodomain-containing transcription factors.
Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog.
Puelles et al., Alacant, Spain. In Front Neuroanat, 2014
We have identified Barhl1, Nhlh1 and Six3 as appropriate molecular markers to the adjacent domains of this transition.
Opportunities and limits of the one gene approach: the ability of Atoh1 to differentiate and maintain hair cells depends on the molecular context.
Fritzsch et al., Iowa City, United States. In Front Cell Neurosci, 2014
However, other gene mutations also result in loss of initially forming HCs, notably null mutants for Pou4f3, Barhl1, and Gfi1.
Bar represses dPax2 and decapentaplegic to regulate cell fate and morphogenetic cell death in Drosophila eye.
Choi et al., Taejŏn, South Korea. In Plos One, 2013
Here we present evidence that BarH1 and BarH2 homeobox genes are essential for eye patterning by inhibiting excess cone cell differentiation and promoting programmed death of IOM cells.
Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.
Maricich et al., Pittsburgh, United States. In Dev Biol, 2013
Furthermore, we show that maintained expression of Barhl1 and Gfi1, two transcription factors implicated in cochlear hair cell survival, depends upon continued Atoh1 expression.
Conditional induction of Math1 specifies embryonic stem cells to cerebellar granule neuron lineage and promotes differentiation into mature granule neurons.
El Ghouzzi et al., Paris, France. In Stem Cells, 2013
Math1 triggered expression of Mbh1 and Mbh2, two target genes directly involved in granule neuron precursor formation and strong expression of early cerebellar territory markers En1 and NeuroD1.
Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.
Fritzsch et al., Iowa City, United States. In Dev Dyn, 2013
The late-onset hair cell death in the absence of early N-Myc expression could be due to mis-regulation of genes necessary for neurosensory formation and maintenance, such as Neurod1, Atoh1, Pou4f3, and Barhl1.
N-Myc and L-Myc are essential for hair cell formation but not maintenance.
Fritzsch et al., Iowa City, United States. In Brain Res, 2012
Previous studies have shown that the deletion of Atoh1 results in embryonic loss of hair cells while the absence of Barhl1, Gfi1, and Pou4f3 leads to the progressive loss of hair cells in newborn mice.
BARHL2 transcription factor regulates the ipsilateral/contralateral subtype divergence in postmitotic dI1 neurons of the developing spinal cord.
Gan et al., Rochester, United States. In Proc Natl Acad Sci U S A, 2012
Here, we show that a single transcription factor (TF), BARHL2, regulates this choice in proprioceptive dI1 interneurons by selectively suppressing cardinal dI1contra features in dI1ipsi neurons, despite expression by both subtypes.
A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability.
Fritzsch et al., Iowa City, United States. In Plos One, 2011
Gene expression analyses of Atoh1, Barhl1 and Pou4f3, genes required for survival and maturation of hair cells, reveal earlier and higher expression levels in the inner compared to the outer hair cells.
Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Schüller et al., München, Germany. In Oncogene, 2011
expression of Barhl1 decelerates tumor growth both in human and in murine medulloblastomas.
Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice.
Wade et al., Ottawa, Canada. In Biochem Biophys Res Commun, 2011
Given the important role of Barhl1 in brain development, it was proposed that perturbations of thyroid hormone -mediated transcriptional control of Barhl1 may play a role in the impaired neurodevelopment induced by hypothyroidism.
Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase.
Kumar et al., Scranton, United States. In J Alzheimers Dis, 2009
We propose that the cycling of MB between the reduced leucomethylene blue (MBH2) and the oxidized (MB) forms may explain, in part, the mitochondria-protecting activities of MB.
Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation.
Saito et al., Chiba, Japan. In Dev Biol, 2008
Math1 directly regulates the Mbh genes in CGCs. Furthermore, a dominant-negative form of the Mbh proteins disrupted proper
Novel approaches to treating sensorineural hearing loss. Auditory genetics and necessary factors for stem cell transplant.
Ferekidis et al., Athens, Greece. In Med Sci Monit, 2008
Brn3c, Gfi1, and Barhl1 are also specific transcription factors that have been implicated in hair cell maintenance and consequent survival.
Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system.
Xiang et al., United States. In Mol Cell Biol, 2008
High-level, cell-specific Bargl1expression in the inner ear & CNS depends on both its 5' promoter & 3' enhancer sequences. 2 homeoprotein binding motifs can be occupied & activated by Barhl1.
Functions of BarH transcription factors during embryonic development.
Concha et al., Santiago, Chile. In Dev Biol, 2007
These genes received the name of BarH due to the Drosophila "Bar" mutant phenotype and, since then, vertebrate homologues (named BarH-like or Barhl) have been described in a number of species of fish, amphibians and mammals.
Expression of Drosophila BarH1-H2 homeoproteins in developing dopaminergic cells and segmental nerve a (SNa) motoneurons.
Carroll et al., Montpellier, France. In Eur J Neurosci, 2006
describe the restricted expression pattern of the B-H2 homeoprotein within the embryonic ventral nerve cord of Drosophila
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