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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NK3 homeobox 2

Bapx1, Nkx3.2
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Shh, Runx2, FATE, COL2A1
Papers on Bapx1
Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.
New
Kim et al., Seoul, South Korea. In Cell Signal, Dec 2015
Here we show that PI3K signaling can down-regulate Nkx3.2 at both mRNA and protein levels in various chondrocyte cultures in vitro.
BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.
Lassar et al., Boston, United States. In Development, 2014
Here we document that SHH-mediated induction of Nkx3.2 maintains the competence of somitic cells to initiate chondrogenesis in response to subsequent BMP signals by repressing BMP-dependent induction of GATA genes.
Pax1 acts as a negative regulator of chondrocyte maturation.
Shukunami et al., Kyoto, Japan. In Exp Cell Res, 2014
Paired box gene 1 (Pax1) indirectly promotes the early stages of chondrogenic differentiation through induction and transactivation of Nk3 homeobox 2 (Nkx3.2),
Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis.
Liao et al., Boston, United States. In Dev Biol, 2013
Further, we found that bapx1 was specifically downregulated in the wnt9a/frzb/fzd7a morphants, while general neural crest markers were unaffected.
Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7.
Welting et al., Maastricht, Netherlands. In Osteoarthritis Cartilage, 2013
Expression of Col2a1, Sox9, Acan, Col10a1, Runx2, ALP, Mmp13, Mef2c and Bapx1/Nkx3.2 was determined by reverse transcription-quantitative PCR (RT-qPCR) and immunoblotting.
Severe neurologic manifestations from cervical spine instability in spondylo-megaepiphyseal-metaphyseal dysplasia.
Superti-Furga et al., Rotterdam, Netherlands. In Am J Med Genet C Semin Med Genet, 2012
Spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD; OMIM 613330) is a dysostosis/dysplasia caused by recessive mutations in the homeobox-containing gene, NKX3-2 (formerly known as BAPX1).
Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem J, 2012
Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation
Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes.
GeneRIF
Myoui et al., Suita, Japan. In Biochem Biophys Res Commun, 2012
These results demonstrated that Nkx3.2-dependent suppression of Runx2 was a crucial factor in hypoxia-dependent maintenance of chondrocyte identity.
Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells.
GeneRIF
Zeng et al., Boston, United States. In Plos One, 2011
the balance of Pax3, Nkx3.2 and Sox9 may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells, which may be important for fracture healing.
Nkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcription.
Myoui et al., Suita, Japan. In Plos One, 2011
BACKGROUND: The Nkx3.2 transcription factor promotes chondrogenesis by forming a positive regulatory loop with a crucial chondrogenic transcription factor, Sox9.
Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
GeneRIF
Kim et al., Seoul, South Korea. In Mol Cell Biol, 2011
Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha.
Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.
GeneRIF
Mortier et al., Gent, Belgium. In Am J Hum Genet, 2009
NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans
Syndromes of the first and second pharyngeal arches: A review.
Review
Fanganiello et al., São Paulo, Brazil. In Am J Med Genet A, 2009
Based on the molecular analysis of balanced translocation in an OAVS patient, it has been suggested that abnormal expression of BAPX1 possibly due to epigenetic disregulation might be involved with the etiology of OAVS.
Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability.
Impact
GeneRIF
Kim et al., Seoul, South Korea. In Nat Cell Biol, 2007
Nkx3.2 supports chondrocyte survival by constitutively activating RelA.
Transcriptional control of chondrocyte fate and differentiation.
Review
Smits et al., Cleveland, United States. In Birth Defects Res C Embryo Today, 2005
This review summarizes and discusses our current knowledge and lack of knowledge about the chondrocyte differentiation pathway, from mesenchymal cells to growth plate and articular chondrocytes, with a main focus on how it is controlled by tissue patterning and cell differentiation transcription factors, such as, but not limited to, Pax1 and Pax9, Nkx3.1 and Nkx3.2,
The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton.
Review
Hill et al., Edinburgh, United Kingdom. In J Anat, 2001
The bagpipe-related homeobox-containing genes are members of the NK family, bagpipe (bap) was first identified in Drosophila and there are three different bagpipe-related genes in vertebrates.
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