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B-cell receptor-associated protein 31

This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: PrP, caspase-8, CAN, bcl-2, Bax
Papers on BAP31
Chimeric transcripts resulting from complex duplications in chromosome Xq28.
Lupski et al., Houston, United States. In Hum Genet, Feb 2016
We experimentally demonstrated the expression of splicing variants of in silico predicted chimeric genes F8/CSAG1 and BCAP31/TEX28 in two individuals with de novo complex genomic rearrangements of Xq28; F8/CSAG1 includes exonization of an ERVL-MaLR intronic repetitive element.
VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis.
Aridor et al., Pittsburgh, United States. In J Biol Chem, Feb 2016
Using this information, we defined functional and physical interactions between VAPB and proteostasis regulators (ligands), including the UPR sensor ATF6 and the ER degradation cluster that included FAF1, VCP, BAP31 and Derlin-1.
Short Report - Clinical Genetics Genomic copy number alterations in non-syndromic hearing loss.
Mingroni-Netto et al., São Paulo, Brazil. In Clin Genet, Nov 2015
Rare copy number variants (CNVs) were detected in 12 probands; four of the detected CNVs comprised genes previously associated with hearing loss (POU4F3, EYA4, USH2A, BCAP31) and were considered causative, stressing the contribution of genomic imbalance to non-syndromic deafness.
Identification of interacting partners of Human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage.
Yasuda et al., Fukui, Japan. In Free Radic Biol Med, Oct 2015
In this study, we investigated the proteins that interact with M-LPH, and identified four: H2A histone family, member X (H2AX), ribosomal protein S14 (RPS14), ribosomal protein S3 (RPS3) and B-cell receptor-associated protein 31 (Bap31).
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.
Hajji et al., London, United Kingdom. In Aging (albany Ny), Sep 2015
We show that there is an adaptive response (AR) to lead, orchestrated by the BAP31-calcium signalling system operating between the ER and mitochondria.
TRAIL-Induced Caspase Activation is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways.
Lee et al., Seoul, South Korea. In J Cell Biochem, Aug 2015
TRAIL-induced ER stress was triggered by caspase-8-mediated cleavage of BAP31 (B cell receptor-associated protein 31).
Epitope Mapping of Antibodies Suggests the Novel Membrane Topology of B-Cell Receptor Associated Protein 31 on the Cell Surface of Embryonic Stem Cells: The Novel Membrane Topology of BAP31.
Ryu et al., Seoul, South Korea. In Plos One, 2014
When located in the endoplasmic reticulum (ER) membrane, B-cell receptor associated protein 31 (BAP31) is involved in the export of secreted proteins from the ER to the plasma membrane.
Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31.
Shore et al., Montréal, Canada. In Biochim Biophys Acta, 2012
Data suggest that endoplasmic reticulum-localized Bcl2 protects against a Bax/Bak-independent cell death pathway initiated by the p20 fragment of Bap31.
The ER-mitochondria interface: the social network of cell death.
Grimm, London, United Kingdom. In Biochim Biophys Acta, 2012
Recent work has also described a reverse transfer of apoptosis signals, from mitochondria to the ER, via cytochrome c release and prolonged IP3R opening or through the mitochondrial fission factor Fis1 and Bap31 at the ER, which form the ARCosome, a novel caspase-activation complex.
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Helenius et al., Zürich, Switzerland. In Nat Cell Biol, 2011
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.
Grimm et al., London, United Kingdom. In Embo J, 2011
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.
Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.
Früh et al., Gainesville, United States. In Plos One, 2009
Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV associate with Bap31 and target CD81 and CD44 to lysosomes
Novel immunohistochemical monoclonal antibody against rat B cell receptor Associated Protein 31 (BAP31).
Jin et al., Xi'an, China. In Hybridoma (larchmt), 2009
generated a novel MAb specific for rat BAP31 in immunohistochemistry and localized BAP31 in some rat tissues. Immunoreactivity of BAP31 was prominent in fundic glands, colon, pancreatic acinuses, and liver but not in skeleton muscle and lung
Viral subversion of immunogenic cell death.
Kroemer et al., Villejuif, France. In Cell Cycle, 2009
CRT normally resides in the lumen of the endoplasmic reticulum (ER), yet can translocate to the plasma membrane surface through a complex pathway that involves elements of the ER stress response (e.g., the eIF2alpha-phosphorylating kinase PERK), the apoptotic machinery (e.g., caspase-8 and its substrate BAP31, Bax, Bak), the anterograde transport from the ER to the Golgi apparatus, and SNARE-dependent exocytosis.
BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.
Shore et al., Montréal, Canada. In Cell, 2008
BAP31 associates with the N terminus of one of its newly synthesized client proteins, the DeltaF508 mutant of CFTR, and promotes its retrotranslocation from the endoplasmic reticulum and degradation by the cytoplasmic 26S proteasome system.
Influence of protein-protein interactions on the cellular localization of cytochrome P450.
Kemper et al., Urbana, United States. In Expert Opin Drug Metab Toxicol, 2008
An ER retention 'receptor' remains elusive, but BAP31 is important for the proper cellular localization of CYPs and Dap1p is a CYP-binding protein that is a candidate for such a receptor.
Assembly of MHC class I molecules within the endoplasmic reticulum.
Williams et al., Toronto, Canada. In Immunol Res, 2005
These include the molecular chaperones calnexin and calreticulin, which enhance the proper folding and subunit assembly of class I molecules and also retain assembly intermediates within the ER; ERp57, a thiol oxidoreductase that promotes heavy chain disulfide formation and proper assembly of the peptide loading complex; tapasin, which recruits class I molecules to the TAP peptide transporter and enhances the loading of high affinity peptide ligands; and Bap31, which is involved in clustering assembled class I molecules at ER exit sites for export along the secretory pathway.
Endoplasmic reticulum quality control and apoptosis.
Michalak et al., Edmonton, Canada. In Acta Biochim Pol, 2004
The luminal environment of the ER contains Ca(2+) which is involved in regulating chaperones such as calnexin and calreticulin, as well as apoptotic proteins caspase-12 and Bap31, which may play an important role in determining cellular sensitivity to ER stress and apoptosis.
Selective export of MHC class I molecules from the ER after their dissociation from TAP.
Edidin et al., Baltimore, United States. In Immunity, 2000
In addition, we show that MHC class I molecules associate with the putative cargo receptor BAP31.
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