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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

B-cell scaffold protein with ankyrin repeats 1

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Kir2.1, STAT4, IRF5, PTPN22, HAD
Papers on BANK
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.
Tsuruyama et al., Kyoto, Japan. In Oncogene, Dec 2015
The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway.
Gene-gene interaction of ATG5, ATG7, BLK and BANK1 in systemic lupus erythematosus.
Liu et al., Jinan, China. In Int J Rheum Dis, Oct 2015
AIM: Autophagy-related gene 5 (ATG5), ATG7, B-lymphoid tyrosine kinase (BLK) and B-cell scaffold protein with ankyrin repeats 1 (BANK1) are involved in B-cell signaling; several genome-wide association studies detected these genes as candidates involved in systemic lupus erythematosus (SLE).
Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Jun 2015
In addition to association to certain MHC alleles and haplotypes, we identified 11 genes (WFDC3, HOMER2, VRK1, PTPN3, WHAMM, BANK1, AP3B2, DAPP1, LAMTOR3, DDIT4L and PPP3CA) located on five chromosomes that contain multiple risk haplotypes correlated with gene expression and disease sub-phenotypes in an intricate manner.
A nonsynonymous SNP in BANK1 is associated with serum LDL cholesterol levels in three Korean populations.
Kim et al., Ch'ŏngju, South Korea. In J Hum Genet, Mar 2015
The rs3733197 is located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1), and the minor allele (A) resulted in the replacement of the Alanine at position 383 with Threonine.
Antiphospholipid syndrome: 30 years and our contribution.
Koike, Sapporo, Japan. In Int J Rheum Dis, Feb 2015
BANK1, BLK and SNP in 1q25.1 region were associated with not only SLE but also APS in Japanese population.
Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia.
Masmoudi et al., Sfax, Tunisia. In Gene, 2014
We aimed to investigate the genetic association of polymorphisms in genes previously linked with other AIDs, namely BANK1, IL15 and IL2/IL21 region.
Lack of association of IRF5 gene polymorphisms with autoimmune thyroid disease: a case-control study. IRF5 gene and AITD.
Zhang et al., Xi'an, China. In Ann Endocrinol (paris), 2014
We further investigated the association between BANK1 gene and IRF5 gene in AITD patients.
Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.
S et al., Recife, Brazil. In Curr Genomics, 2014
IRF5, PTPN22, CTLA4, STAT4 and BANK1).
Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.
Zhou et al., Houston, United States. In Open Rheumatol J, 2013
These genes include HLA genes, STAT4, CD247, TBX21, PTPN22, TNFSF4, IL23R, IL2RA, IL-21, SCHIP1/IL12A, CD226, BANK1, C8orf13-BLK, PLD4, TLR-2, NLRP1, ATG5, IRF5, IRF8, TNFAIP3, IRAK1, NFKB1, TNIP1, FAS, MIF, HGF, OPN, IL-6, CXCL8, CCR6, CTGF, ITGAM, CAV1, MECP2, SOX5, JAZF1, DNASEIL3, XRCC1, XRCC4, PXK, CSK, GRB10, NOTCH4, RHOB, KIAA0319, PSD3 and PSOR1C1.
Survival of red blood cells after transfusion: processes and consequences.
Bosman, Nijmegen, Netherlands. In Front Physiol, 2012
THE CURRENTLY AVAILABLE DATA SUGGEST THAT EFFORTS TOWARD IMPROVING THE QUALITY OF RED BLOOD CELL (RBC) BLOOD BANK PRODUCTS SHOULD CONCENTRATE ON: (1) preventing the removal of a considerable fraction of the transfused RBCs that takes place within the first hours after transfusion; (2) minimizing the interaction of the transfused RBCs with the patient's immune system.
The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization.
Castillejo-López et al., Uppsala, Sweden. In Genes Immun, 2012
short Delta2 isoform of BANK1 displays a homogeneous cytoplasmic distribution
Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.
Alarcón-Riquelme et al., Oklahoma City, United States. In Ann Rheum Dis, 2012
This study shows a genetic interaction between BANK1 and BLK, and demonstrates that these molecules interact physically.
Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.
Kere et al., Huddinge, Sweden. In Rheumatology (oxford), 2012
Association between SLE and TNFAIP3, FAM167A-BLK, BANK1 and KIAA1542 was also confirmed, although at a lower significance level and contribution to individual risk.
Association analysis of BANK1 gene with psoriasis in Southern Han Chinese.
Guan et al., Shanghai, China. In Int J Immunogenet, 2011
Polymorphism in BANK1 is associated with susceptibility to psoriasis in Southern Han Chinese.
Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes.
van der Pol et al., Utrecht, Netherlands. In J Peripher Nerv Syst, 2011
allelic variation in BANK1 does not play a major role in determining multifocal motor neuropathy susceptibility.
The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
Ye et al., Hefei, China. In Int J Immunogenet, 2011
This meta-analysis demonstrates a significant association between BANK1 and TNFAIP3 gene polymorphism and systemic lupus erythematosus in multiple ethnic populations.
Genetic susceptibility to systemic lupus erythematosus in the genomic era.
Tsao et al., Los Angeles, United States. In Nat Rev Rheumatol, 2010
These techniques have identified more than 30 robust genetic associations with SLE including genetic variants of HLA and Fcγ receptor genes, IRF5, STAT4, PTPN22, TNFAIP3, BLK, BANK1, TNFSF4 and ITGAM.
What can we learn from genetic studies of systemic lupus erythematosus? Implications of genetic heterogeneity among populations in SLE.
Bae et al., Seoul, South Korea. In Lupus, 2010
One might assign these candidate genetic factors into several pre-existing biological pathways: (i) innate immune response including TLR/interferon signaling pathways (IRF5, STAT4, TNFAIP3, and TREX1); (ii) adaptive immune response (HLA-DR, PTPN22, PDCD1, STAT4, LYN, BLK, and BANK1) including B, T cells, and antigen-presenting cells; and (iii) immune complex clearance mechanism (FCGRs, CRP, and ITGAM).
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.
Alarcón-Riquelme et al., Uppsala, Sweden. In Nat Genet, 2008
Functional variants in the B-cell gene BANK1 are assoicated with systemic lupus erythematosus.
BANK negatively regulates Akt activation and subsequent B cell responses.
Kurosaki et al., Yokohama, Japan. In Immunity, 2006
BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses.
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