Activins and activin antagonists in hepatocellular carcinoma.
Vienna, Austria. In World J Gastroenterol, 2008
Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG, and at the cell membrane antagonistic co-receptors like Cripto or BAMBI.
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
New York City, United States. In Nat Med, 2007
In quiescent HSCs, TLR4 activation not only upregulates chemokine secretion and induces chemotaxis of Kupffer cells, but also downregulates the transforming growth factor (TGF)-beta pseudoreceptor Bambi to sensitize HSCs to TGF-beta-induced signals and allow for unrestricted activation by Kupffer cells.
Antagonists of activin signaling: mechanisms and potential biological applications.
Australia. In Trends Endocrinol Metab, 2005
Recent studies have revealed details of the roles of inhibin, betaglycan, follistatin and its related protein follistatin-related gene (FLRG), Cripto and BAMBI in antagonizing activin action, and exogenous antagonists against the activin type I (SB-431542 and SB-505124) and type II (activin-M108A) receptors have been developed.