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BMP and activin membrane-bound inhibitor homolog

BAMBI, BMP and activin membrane-bound inhibitor
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SFRP1, TGF-beta, CAN, BMP4, V1a
Papers on BAMBI
Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis.
New
McLoughlin et al., Dublin, Ireland. In Am J Pathol, Feb 2016
We report significant increases in mRNA expression of gremlin 1, noggin, follistatin, and follistatin-like 1 (Fstl1), and significant decreases in mRNA expression of chordin, kielin/chordin-like protein, nephroblastoma overexpressed gene, and BMP and activin membrane-bound inhibitor (BAMBI).
BAMBI a TGFβ rheostat that controls regulatory T/TH 17 differentiation and the development of autoimmune arthritis by reducing IL-2 signaling.
New
Merino et al., Santander, Spain. In Arthritis Rheumatol, Jan 2016
Here, we explore the contribution of BAMBI (BMP and Activin Membrane Bound Inhibitor) to the modulation of TGFβ activity during the differentiation of CD4(+) cells and in the control of immunological tolerance.
Myocardial expression of transforming growth factor beta family and endothelin-1 in the progression from heart failure to ascites in broilers with cold-induced pulmonary hypertension.
New
Sánchez et al., Mexico. In J Recept Signal Transduct Res, Dec 2015
UNASSIGNED: We determined mRNA expression of genes of endothelin-1 (ET-1), and of the transforming growth factor beta ligands (TGFβ1, TGFβ2 and TGFβ3), their receptors (TβRI and TβRII) and their pseudoreceptor BAMBI in the heart of broilers raised under cold temperature conditions and affected by pulmonary hypertension.
Investigation of common and rare genetic variation in the BAMBI genomic region in light of human obesity.
New
Van Hul et al., Antwerp, Belgium. In Endocrine, Nov 2015
UNASSIGNED: The aim of this study was to confirm the previously identified link between BAMBI and human obesity by means of a genetic and functional analysis.
Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.
Mason et al., Philadelphia, United States. In Plos One, 2014
Expression of TGFβ target genes, such as TGFBI, BAMBI, COL3A1 and SERPINE1 was significantly increased in the DBA iPSCs.
BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/β-Catenin Signaling.
Li et al., China. In Int J Mol Sci, 2014
Bone morphogenic protein and activin membrane-bound inhibitor (BAMBI) is regarded as an essential regulator of cell proliferation and differentiation that represses transforming growth factor-β and enhances Wnt/β-catenin signaling in various cell types.
BAMBI inhibits skin fibrosis in keloid through suppressing TGF-β1-induced hypernomic fibroblast cell proliferation and excessive accumulation of collagen I.
Huang et al., Yantai, China. In Int J Clin Exp Med, 2014
Here, we found that BMP and activin membrane-bound inhibitor (BAMBI), a pseudo-receptor of TGF-β1, was being decreased during the human keloid development and in vitro keloid cell growth.
BMP-7 counteracting TGF-beta1 activities in organ fibrosis.
Review
Meurer et al., Aachen, Germany. In Front Biosci, 2012
CCN proteins), Endoglin, Betaglycan, BAMBI and the members of the repulsive guidance molecule family that modulate cellular proliferation, migration, adhesion and extracellular matrix production.
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.
GeneRIF
Downes et al., Sydney, Australia. In Cancer Prev Res (phila), 2012
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling
Transforming growth factor-β in normal nociceptive processing and pathological pain models.
Review
Hurlé et al., Santander, Spain. In Mol Neurobiol, 2012
The strategy of increasing TGF-β signaling by deleting "BMP and activin membrane-bound inhibitor" (BAMBI), a TGF-β pseudoreceptor, has demonstrated the inhibitory role of TGF-β signaling pathways in normal nociception and in inflammatory and neuropathic pain models.
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.
GeneRIF
Whitehead et al., China. In Diabetes, 2012
Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function.
Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes.
GeneRIF
Buechler et al., Regensburg, Germany. In Febs Lett, 2011
Data show that hepatoprotective effects of adiponectin include induction of BAMBI which is reduced in human fatty liver.
The TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae.
GeneRIF
Goldmann et al., Lübeck, Germany. In Respir Res, 2009
Expression of the TGF pseudoreceptor BAMBI in the human lung, which is upregulated in response to nontypeable Haemophilus influenzae infection in COPD lung tissue in vivo and in vitro.
BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.
GeneRIF
Schlondorff et al., New York City, United States. In Plos One, 2009
BAMBI protein is expressed in endothelial cells and is regulated by autophagy and lysosomal degradation.
Activins and activin antagonists in hepatocellular carcinoma.
Review
Grusch et al., Vienna, Austria. In World J Gastroenterol, 2008
Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG, and at the cell membrane antagonistic co-receptors like Cripto or BAMBI.
TLR4 enhances TGF-beta signaling and hepatic fibrosis.
Impact
Schwabe et al., New York City, United States. In Nat Med, 2007
In quiescent HSCs, TLR4 activation not only upregulates chemokine secretion and induces chemotaxis of Kupffer cells, but also downregulates the transforming growth factor (TGF)-beta pseudoreceptor Bambi to sensitize HSCs to TGF-beta-induced signals and allow for unrestricted activation by Kupffer cells.
Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
Impact
De Robertis et al., Los Angeles, United States. In Cell, 2006
The ventral BMP antagonists Sizzled and Bambi further refine the pattern.
Antagonists of activin signaling: mechanisms and potential biological applications.
Review
Robertson et al., Australia. In Trends Endocrinol Metab, 2005
Recent studies have revealed details of the roles of inhibin, betaglycan, follistatin and its related protein follistatin-related gene (FLRG), Cripto and BAMBI in antagonizing activin action, and exogenous antagonists against the activin type I (SB-431542 and SB-505124) and type II (activin-M108A) receptors have been developed.
Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators.
Review
Van Hul et al., Antwerp, Belgium. In Dev Biol, 2002
Second, at the membrane site, the pseudoreceptor BAMBI/Nma is able to inhibit further signaling within the cells.
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
Impact
Niehrs et al., Heidelberg, Germany. In Nature, 1999
Here, we have cloned a transmembrane protein, BAMBI, which is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain.
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