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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dual adaptor of phosphotyrosine and 3-phosphoinositides

Bam32, DAPP1
Top mentioned proteins: Src, V1a, PI3K, BCR, JNK
Papers on Bam32
Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Jun 2015
In addition to association to certain MHC alleles and haplotypes, we identified 11 genes (WFDC3, HOMER2, VRK1, PTPN3, WHAMM, BANK1, AP3B2, DAPP1, LAMTOR3, DDIT4L and PPP3CA) located on five chromosomes that contain multiple risk haplotypes correlated with gene expression and disease sub-phenotypes in an intricate manner.
Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface.
Sansom et al., Yokohama, Japan. In Sci Rep, 2014
We use multiscale molecular dynamics simulations to characterize the localization and anomalous dynamics of the DAPP1 PH domain on the surface of a PIP-containing lipid bilayer.
[Whole genome methylation profiles of myelodysplastic syndrome and its diagnostic value].
Lin et al., Shanghai, China. In Zhonghua Xue Ye Xue Za Zhi, 2014
The hypermethylated genes were ABAT (97%), DAPP1 (98%), FADD (89%), LRRFIP1 (96%), PLBD1 (89%), and SMPD3 (85%).
Genome-wide association study reveals genetic architecture of eating behavior in pigs and its implications for humans obesity by comparative mapping.
Kadarmideen et al., Frederiksberg, Denmark. In Plos One, 2012
Synapse genes (GABRR2, PPP1R9B, SYT1, GABRR1, CADPS2, DLGAP2 and GOPC), dephosphorylation genes (PPM1E, DAPP1, PTPN18, PTPRZ1, PTPN4, MTMR4 and RNGTT) and positive regulation of peptide secretion genes (GHRH, NNAT and TCF7L2) were highly significantly associated with feeding behavior traits.
A discovery resource of rare copy number variations in individuals with autism spectrum disorder.
Scherer et al., Toronto, Canada. In G3 (bethesda), 2012
Several of the CGH-specific CNVs are rare in population frequency and impact previously reported ASD genes (e.g., NRXN1, GRM8, DPYD), as well as novel ASD candidate genes (e.g., CIB2, DAPP1, SAE1), and all were inherited except for a de novo CNV in the GPHN gene.
High-dimensional gene expression profiling studies in high and low responders to primary smallpox vaccination.
Poland et al., Rochester, United States. In J Infect Dis, 2012
DAPP1, P = .0003;
The adaptor protein Bam32 in human dendritic cells participates in the regulation of MHC class I-induced CD8+ T cell activation.
Heufler et al., Innsbruck, Austria. In J Immunol, 2011
we propose a role for Bam32 in the signaling of MHC class I molecules in professional Ag-presenting DC for the regulation of CD8(+) T cell activation.
The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain FcɛRI-induced calcium flux and granule release.
Marshall et al., Winnipeg, Canada. In Mol Immunol, 2010
our results identify Bam32 as a novel regulator of mast cell activation
Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.
Marshall et al., Winnipeg, Canada. In J Immunol, 2010
Bam32 serves to integrate PI3K and Src kinase signaling to promote Rac-dependent B cell adhesive interactions important for Ag presentation function.
The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression.
Marshall et al., Canada. In J Immunol, 2010
Bam32 is not required for germinal center (GC) initiation, but rather functions in a late checkpoint of GC progression associated with T cell recruitment and GC B cell survival.
Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation.
Marshall et al., Winnipeg, Canada. In Immunol Rev, 2009
Bam32/DAPP1 and SKAPs function to promote activation of monomeric guanosine triphosphatases, including Rac and Rap, and promote integrin activation, lymphocyte adhesion to matrix proteins, and cell:cell interactions between B and T lymphocytes.
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Sommers et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2009
Data show that Erk activation was diminished in LAT knock-in Bam32 knockout CD4(+) T cells.
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains.
Cho et al., Chicago, United States. In J Biol Chem, 2007
To understand how these PH domains differentially respond to PtdIns(3,4)P2 and PtdIns(3,4,5)P3 signals, we quantitatively determined the PtdIns(3,4)P2 and PtdIns(3,4,5)P3 binding properties of several PH domains, including Akt, ARNO, Btk, DAPP1, Grp1, and C-terminal TAPP1 PH domains by surface plasmon resonance and monolayer penetration analyses.
Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1.
Al-Alwan et al., Winnipeg, Canada. In Biochem Soc Trans, 2007
Here, we review data on the PH domain-containing adaptor protein Bam32 (B-cell adaptor molecule of 32 kDa)/DAPP1 (dual adaptor for phosphotyrosine and 3-phosphoinositides 1), focusing on its functions in B-lymphocyte activation.
Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms.
Junop et al., Canada. In Acta Crystallogr D Biol Crystallogr, 2006
Structural comparisons between the phosphoinositide-binding loops of the C-PH crystal structure and the PH domains of DAPP1 and TAPP1, the N-terminal PH domain of pleckstrin and a recently described solution structure of C-PH are presented and discussed.
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Marshall et al., Winnipeg, Canada. In Immunol Lett, 2005
Bam32/DAPP1 and the related adaptor proteins TAPP1 and TAPP2 were identified by multiple groups about 5 years ago and considerable progress has been made in elucidating the structure, interaction partners and function of these molecules.
The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses.
Skolnik et al., New York City, United States. In Curr Biol, 2003
BACKGROUND: Bam32/DAPP1 is a B cell adaptor composed of both a PH and an SH2 domain.
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