IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response
In The Journal of Cell Biology, 2003
... IKKβ, phospho-JNK, JNK, phospho-MKK4, MKK4, phospho-MKK7, MKK7, phospho-c-Jun, c-Jun, caspase3, PARP, Bcl-2, Bcl-XL, Bax, and Bak were purchased from Cell Signaling Technology ...
Lovastatin induces platelet apoptosis.
Suzhou, China. In Environ Toxicol Pharmacol, Feb 2016
In the current study, we show that lovastatin dose-dependently induces depolarization of mitochondrial inner transmembrane potential, leading to up-regulation of Bak, down-regulation of Bcl-XL, and activation of caspase-3/8/9.
Regulated necrotic cell death: the passive aggressive side of Bax and Bak.
Cincinnati, United States. In Circ Res, Jun 2015
In apoptosis, the B-cell leukemia/lymphoma 2 (Bcl-2) family members Bcl-2-associated protein x (Bax) and Bcl-2 homologues antagonist/killer (Bak) undergo oligomerization in the outer mitochondrial membrane resulting in the release of apoptosis inducing substrates and the activation of caspases and nucleases.
Apoptosis and in vivo models to study the molecules related to this phenomenon.
São Paulo, Brazil. In Einstein (sao Paulo), 2010
Antiapoptotic members of the Bcl-2 family (B cell CLL/lymphoma 2), that belong to the intrinsic route of the activation of caspases, such as Bcl-xL (extra-large B-cell lymphoma) and Bcl-w (Bcl-2-like 2), act predominantly to prevent that pro-apoptotic members, such as Bax (Bcl-2-associated X protein) and Bak (Bcl-2 relative bak) lead to cell death.