Germline and somatic mutations in meningiomas.
Manchester, United Kingdom. In Cancer Genet, Apr 2015
Recently, a second SWI/SNF complex subunit, SMARCE1, was identified as a cause of clear cell meningiomas, indicating a wider role for this complex in meningioma disease.
SWI/SNF chromatin remodeling complexes and cancer.
In Am J Med Genet C Semin Med Genet, 2014
These include germline mutations and copy number alterations in SMARCB1, SMARCA4, SMARCE1, and PBRM1 that predispose carriers to both benign and malignant neoplasms.
Seattle, United States. In Unknown Journal, 2013
With the recent detection of heterozygous pathogenic variants in ARID1A, ARID1B, SMARCA4, SMARCB1, or SMARCE1 in some (but not all) individuals with CSS, it is likely that diagnostic criteria will evolve.
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.
Los Angeles, United States. In Cell, 1998
E-RC1 contains BRG1, BAF170, BAF155, and INI1 (BAF47) homologs of yeast SWI/SNF subunits, as well as a subunit unique to higher eukaryotes, BAF57, which is critical for chromatin remodeling and transcription with EKLF.