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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

BAF170, SMARCC2
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BRG1, SWI, SWI3, INI1, BAF57
Papers using BAF170 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Supplier
Copenhaver Gregory P., In PLoS Genetics, 2006
... 1) anti-Ini1 (C-20), Santa Cruz Biotechnology, sc-16189; 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), Santa Cruz Biotechnology, sc-10757; 4) anti-Brg1 (G-7), ...
Papers on BAF170
Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.
New
Tuoc et al., Göttingen, Germany. In Cell Rep, Jan 2016
Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in active chromatin marks (H3K9Ac), a global increase in repressive marks (H3K27me2/3), and downregulation of gene expression.
MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs.
New
Archer et al., United States. In Stem Cells, Oct 2015
Here, we provide data to show that miR-302 regulates Brg1 chromatin remodeling complex composition in human embryonic stem cells (hESCs) through direct repression of the BAF53a and BAF170 subunits.
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.
New
Gursoy et al., İstanbul, Turkey. In Biophys J, Oct 2015
They further suggest that a BAF60a/BAF155 and/or BAF60a/BAF170 interaction is critical for association between the core and variant subunits.
Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling.
New
Kohtz et al., Chicago, United States. In Development, Sep 2015
In this report, mass spectrometry shows that the Evf2-DLX1 ribonucleoprotein (RNP) contains the SWI/SNF-related chromatin remodelers Brahma-related gene 1 (BRG1, SMARCA4) and Brahma-associated factor (BAF170, SMARCC2) in the developing mouse forebrain.
Transcriptional repression by the BRG1-SWI/SNF complex affects the pluripotency of human embryonic stem cells.
Wang et al., Shanghai, China. In Stem Cell Reports, 2014
A unique composition of the BRG1-SWI/SNF complex in hESCs was further defined by the presence of BRG1, BAF250A, BAF170, BAF155, BAF53A, and BAF47.
Genetic variants in SMARC genes are associated with DNA damage levels in Chinese population.
Shen et al., Nanjing, China. In Toxicol Lett, 2014
To test this hypothesis, we genotyped a total of 20 polymorphisms in five key SMARC genes (SMARCA5, SMARCC2, SMARCD1, SMARCD2, SMARCD3) to evaluate their associations with DNA damage levels in 307 subjects.
SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability.
Yasui et al., Chiba, Japan. In Cancer Res, 2014
The suppression of other SWI/SNF factors, namely SNF5, BAF60a, BAF60c, BAF155, or BAF170, exhibits a similar phenotype.
Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.
Krupitza et al., Vienna, Austria. In Br J Cancer, 2013
The hSWI/SNF (human SWItch/Sucrose NonFermentable) chromatin remodelling complex, which is tightly linked to nucleosome acetylation and repositioning, was also affected, because as a stress response to FUL treatment-naive cells altered the expression of five subunits within a few hours (BRG1, BAF250A, BAF170, BAF155, BAF47).
BAF chromatin remodeling complex: cortical size regulation and beyond.
Stoykova et al., Göttingen, Germany. In Cell Cycle, 2013
Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to control cortical size and volume.
ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome.
Morris et al., Sydney, Australia. In Mol Biol Rep, 2013
At the FDR ≤1.3 significance level we found that ZRANB2 influenced the alternative splicing of primary transcripts of CENTB1, WDR78, C10orf18, CABP4, SMARCC2, SPATA13, OR4C6, ZNF263, CAPN10, SALL1, ST18 and ZP2.
Chromatin regulation by BAF170 controls cerebral cortical size and thickness.
Stoykova et al., Göttingen, Germany. In Dev Cell, 2013
Here, we show that mammalian BAF170, a subunit of the chromatin remodeling complex mSWI/SNF, is an intrinsic factor that controls cortical size.
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Xu et al., New York City, United States. In Development, 2012
We demonstrate that EYA1 and SIX1 interact directly with the SWI/SNF chromatin-remodeling subunits BRG1 and BAF170 to drive neurogenesis cooperatively in 3T3 cells and cochlear nonsensory epithelial cells, and that SOX2 cooperates with these factors to mediate neuronal differentiation.
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.
Bjørås et al., Oslo, Norway. In Plos One, 2011
Immunofluorescence microscopy revealed that SMARCB1 along with BRG-1, BAF170 and BAF155, which are the core SWI/SNF components required for efficient chromatin remodeling, were present in virus replication foci 24-48 hours post infection (hpi).
Varying modulation of HIV-1 LTR activity by Baf complexes.
GeneRIF
Kashanchi et al., Manassas, United States. In J Mol Biol, 2011
study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells
BRIT1/MCPH1 links chromatin remodelling to DNA damage response.
Impact
Lin et al., Houston, United States. In Nat Cell Biol, 2009
After damage to DNA, BRIT1 increases its interaction with SWI-SNF through ATM/ATR-dependent phosphorylation on the BAF170 subunit.
Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.
GeneRIF
Archer et al., United States. In Mol Cell Biol, 2005
protein levels of BAF155/170 dictate the maximum cellular amount of BAF57
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.
Impact
Emerson et al., Los Angeles, United States. In Cell, 1998
E-RC1 contains BRG1, BAF170, BAF155, and INI1 (BAF47) homologs of yeast SWI/SNF subunits, as well as a subunit unique to higher eukaryotes, BAF57, which is critical for chromatin remodeling and transcription with EKLF.
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