BH3-only proteins: a 20-year stock-take.
Melbourne, Australia. In Febs J, Mar 2015
Since the discovery of the first BH3-only protein BAD almost 20 years ago, at least seven more BH3-only proteins have been identified in mammals.
Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy.
London, United Kingdom. In Nat Rev Gastroenterol Hepatol, 2014
Increasing evidence, including that from several large case series using SeHCAT (selenium homocholic acid taurine) tests for diagnosis, indicates that bile acid diarrhoea (BAD) accounts for a sizeable proportion of patients who would otherwise be diagnosed with IBS.
Nitric oxide as a mediator of estrogen effects in osteocytes.
San Diego, United States. In Vitam Horm, 2013
Moreover, we found that 17β-estradiol protects osteocytes against apoptosis via the NO/cGMP signaling pathway: type II PKG mediates estradiol-induced activation of the prosurvival kinases Erk and Akt, whereas type I PKG contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein BAD.
[Concept, pathophysiology and treatment for branch atheromatous disease].
Kyoto, Japan. In Rinsho Shinkeigaku, 2013
Small deep brain infarcts are often caused by two different vascular pathologies: 1. atheromatous occlusion at the orifice of large caliber penetrating arteries termed branch atheromatous disease (BAD) and 2. lipohyallinotic degenerative changes within the course of penetrating arteries termed lipohyalinitic degeneration.
When BAD is good for beta cells.
Chicago, United States. In Cell Metab, 2008
BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation.