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BTB and CNC homology 1, basic leucine zipper transcription factor 2

Bach2
Top mentioned proteins: CAN, SET, HAD, bcl-6, OUT
Papers on Bach2
Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.
New
Noble et al., Berkeley, United States. In J Autoimmun, Feb 2016
Initial results showed modest methylation differences between discordant MZ twins for the MHC region and T1D-associated CpG sites, BACH2, INS-IGF2, and CLEC16A (DNAm difference range: 2.2%-5.0%).
The transcription factor BACH2 promotes tumor immunosuppression.
New
Restifo et al., In J Clin Invest, Feb 2016
The transcription factor (TF) BACH2 regulates the differentiation of multiple innate and adaptive cellular lineages, but its role in controlling tumor immunity has not been elucidated.
DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer.
New
Flanagan et al., Salt Lake City, United States. In Epigenetics, Feb 2016
Three validated markers (BACH2, C8orf31, and LOC654342) were combined with sequence bioinformatics in a model to predict pathogenicity of 27 variants (independent test set).
A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis.
New
Jawaheer et al., Tochigi, Japan. In Arthritis Res Ther, Dec 2015
Potential candidate genes in these regions include MAP3K7, BACH2 (6q15), GFRA1 (10q25.3),
Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes.
New
Type 1 Diabetes Genetics Consortium et al., Copenhagen, Denmark. In Diabetes Care, Oct 2015
In addition to the MHC region, we identify SNPs in five susceptibility loci (IFIH1, PTPN22, SH2B3, BACH2, and CTLA4) as significantly associated with more than one autoantibody at a false discovery rate less than 5%.
Super-enhancers delineate disease-associated regulatory nodes in T cells.
New
Impact
O'Shea et al., Bethesda, United States. In Nature, May 2015
Nonetheless, the locus encoding Bach2, a key negative regulator of effector differentiation, emerged as the most prominent T-cell SE, revealing a network in which SE-associated genes critical for T-cell biology are repressed by BACH2.
Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation.
McManus et al., Dublin, Ireland. In Plos One, 2014
Two modules were particularly highly enriched for differentially expressed genes (P<2.2x10(-16)) and highlighted IFNy and the genetically associated transcription factor BACH2 which showed significantly reduced expression in coeliac samples (log2FC -1.75; P(adjusted) = 3.6x10(-3)) as key regulatory genes in CD.
Transcriptional and metabolic pre-B cell receptor-mediated checkpoints: implications for autoimmune diseases.
Review
Zouali, Paris, France. In Mol Immunol, 2014
Thus, the transcription factor BACH2, which represents a susceptibility locus for rheumatoid arthritis, has recently emerged as a crucial mediator of negative selection at a pre-BCR checkpoint.
Common Viral Integration Sites Identified in Avian Leukosis Virus-Induced B-Cell Lymphomas.
Beemon et al., Baltimore, United States. In Mbio, 2014
In addition to the four genes implicated previously, we identify other genes as common integration sites, including TNFRSF1A, MEF2C, CTDSPL, TAB2, RUNX1, MLL5, CXorf57, and BACH2.
Uncovering MicroRNA Regulatory Hubs that Modulate Plasma Cell Differentiation.
Lin et al., Taipei, Taiwan. In Sci Rep, 2014
Cohorts of differentially expressed miRNAs cooperating as miRNA hubs were predicted and validated to modulate key TFs, including a down-regulated miRNA hub containing miR-101-3p, -125b-5p, and -223-3p contributing to induction of PRDM1 as well as an up-regulated miRNA hub containing miR-34a-5p, -148a-3p, and -183-5p suppressing BCL6, BACH2, and FOXP1.
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
Impact
Hughes et al., Frederick, United States. In Science, 2014
There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells.
BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
Review
Müschen et al., San Francisco, United States. In Trends Immunol, 2014
This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint.
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.
Impact
Müschen et al., San Francisco, United States. In Nat Med, 2013
The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells.
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.
Impact
Restifo et al., Bethesda, United States. In Nature, 2013
Genetic polymorphisms within a single locus encoding the transcription factor BACH2 are associated with numerous autoimmune and allergic diseases including asthma, Crohn's disease, coeliac disease, vitiligo, multiple sclerosis and type 1 diabetes.
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
Impact
Spritz et al., Aurora, United States. In Nat Genet, 2012
× 10(-13)), IFIH1 (P = 4.91 × 10(-15)), CD80 (P = 3.78 × 10(-10)), CLNK (P = 1.56 × 10(-8)), BACH2 (P = 2.53 × 10(-8)), SLA (P = 1.58 × 10(-8)), CASP7 (P = 3.56 × 10(-8)), CD44 (P = 1.78 × 10(-9)), IKZF4 (P = 2.75 × 10(-14)), SH2B3 (P = 3.54 × 10(-18)) and TOB2 (P = 6.81 × 10(-10)).
The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond.
GeneRIF
Wright et al., Leeds, United Kingdom. In Acta Crystallogr D Biol Crystallogr, 2012
crystal structure of the human Bach2 POZ domain is reported at 2.1 A resolution
A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1.
GeneRIF
Burmeister et al., Berlin, Germany. In Genes Chromosomes Cancer, 2011
This is the first report that shows the involvement of both BCL2L1 and the transcription factor BACH2 in a chromosomal rearrangement.
Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2.
GeneRIF
Igarashi et al., Sendai, Japan. In Blood, 2011
Heme oxygenase-1, which is known to be regulated by heme, was repressed by both Bach2 and Bach1 in B cells.
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch.
GeneRIF
Igarashi et al., Sendai, Japan. In Embo J, 2011
In the absence of Bach2 encoding a transcription factor required for class switch DNA recombination, mouse splenic B cells more frequently and rapidly expressed Blimp-1 and differentiated to IgM plasma cells as compared with wild-type cells.
Identification of novel Bach2 transcripts and protein isoforms through tagging analysis of retroviral integrations in B-cell lymphomas.
GeneRIF
Pedersen et al., Århus, Denmark. In Bmc Mol Biol, 2008
An alternative Bach2 promoter was identified within intron 2.
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