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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G-2 and S-phase expressed 1

b99, GTSE-1
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, p53, ACID, OUT, PA26
Papers on b99
Combined analysis identifies six genes correlated with augmented malignancy from non-small cell to small cell lung cancer.
Shou et al., Beijing, China. In Tumour Biol, Oct 2015
Transcript levels of BUB1, E2F1, ESPL1, GTSE1, RAB3B, and U2AF2 were found significantly elevated from normal, ADC, SQC, LCC to SCLC.
Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome.
Levine et al., New York City, United States. In Neoplasia, Feb 2015
External validation confirmed differential expression in 31 genes (P < 4.4 × 10(-4), Bonferroni corrected), with 84% of the overexpressed genes, including CDC7, CDC20, GTSE1, CCNA2, CCNB1, and CCNB2, participating in cell cycle regulation.
Biological effects of passive versus active scanning proton beams on human lung epithelial cells.
Luo-Owen et al., Loma Linda, United States. In Technol Cancer Res Treat, Feb 2015
In contrast, many more genes had >2-fold difference with ABS protons: BRCA1, BRCA2, CDC25A, CDC25C, CCNB2, CDK1, DMC1, DNMT1, E2F1, EXO1, FEN1, GADD45A, GTSE1, IL-6, JUN, KRAS, MDM4, PRC1, PTTG1, RAD51, RPA1, TNF, WT1, XRCC2, XRCC3 and XRCC6BP1.
GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.
Yong et al., Singapore, Singapore. In Bmc Cancer, 2014
In this study, we aimed to identify the expression of GTSE1 and its correlation with cisplatin resistance in gastric cancer cells.
Differentially expressed genes in metastatic advanced Egyptian bladder cancer.
Abu-Taleb et al., Cairo, Egypt. In Asian Pac J Cancer Prev, 2014
RESULTS: Five hundred and sixteen genes were differentially expressed of which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1, and SRP68 genes were involved in 33 different pathways.
Mmp-9 inhibition: a therapeutic strategy in ischemic stroke.
Kaczmarek et al., Warsaw, Poland. In Mol Neurobiol, 2014
In next part, the literature is organized as various approaches which have proven neuroprotective effects through direct or indirect decrease in MMP-9 activity, namely, using biotherapeutics, involving MMP-9 gene inhibition using viral vectors; using endogenous inhibitor of MMP-9, repurposing of old drugs such as minocycline, new chemical entities like DP-b99, and finally other approaches like therapeutic hypothermia.
DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity.
Figiel et al., Warsaw, Poland. In Plos One, 2013
DP-b99 is a membrane-activated chelator of zinc and calcium ions, recently proposed as a therapeutic agent.
Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.
Brechbiel et al., Bethesda, United States. In Plos One, 2013
Differentially expressed genes following therapy with Pac/²¹²Pb-trastuzumab included those involved in apoptosis (BRCA1, CIDEA, GADD45α, GADD45γ, GML, IP6K3, PCBP4, PPP1R15A, RAD21, and p73), cell cycle (BRCA1, CHK1, CHK2, GADD45α, GML, GTSE1, NBN, PCBP4, PPP1R15A, RAD9A, and SESN1), and damaged DNA repair (ATRX, BTG2, EXO1, FEN1, IGHMBP2, OGG1, MSH2, MUTYH, NBN, PRKDC, RAD21, and p73).
Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs.
Shapiro et al., Baltimore, United States. In Parasitol Int, 2013
A dose-response relationship study using validated viability assays revealed that two MAC drugs, DP-b99 and DP-460, were cytotoxic for these parasites in vitro.
Gene expression profiling upon (212) Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model.
Brechbiel et al., Bethesda, United States. In Cancer Med, 2013
These included genes involved in apoptosis (ABL, GADD45α, GADD45γ, PCBP4, and p73), cell cycle (ATM, DDIT3, GADD45α, GTSE1, MKK6, PCBP4, and SESN1), and damaged DNA binding (DDB) and repair (ATM and BTG2).
Results of Membrane-Activated Chelator Stroke Intervention randomized trial of DP-b99 in acute ischemic stroke.
MACSI Investigators et al., Glasgow, United Kingdom. In Stroke, 2013
BACKGROUND AND PURPOSE: DP-b99, a lipophilic moderate-affinity chelator of zinc, was postulated to improve recovery after acute ischemic stroke.
Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation.
Papoutsakis et al., Evanston, United States. In Physiol Genomics, 2012
Among substantially downregulated p53 targets in p53-KD megakaryocytes were cell cycle regulators CDKN1A (p21) and PLK2, proapoptotic FAS, TNFRSF10B, CASP8, NOTCH1, TP53INP1, TP53I3, DRAM1, ZMAT3 and PHLDA3, DNA-damage-related RRM2B and SESN1, and actin component ACTA2, while antiapoptotic CKS1B, BCL2, GTSE1, and p53 family member TP63 were upregulated in p53-KD cells.
Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene.
Park et al., Seoul, South Korea. In Plos One, 2011
RESULTS: We first delineated six candidate genes for metastasis including ATM, CCND2, RBL2, CDKN3, CCNB1, and GTSE1.
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
Bird et al., Trieste, Italy. In Plos One, 2011
Here we identify a +TIP, GTSE1, that promotes cell migration.
Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.
Xing et al., Beijing, China. In Asian Pac J Cancer Prev, 2010
GTSE1 is overexpressed dramatically in lung cancer patients' tissues.
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.
Liu et al., West Lafayette, United States. In Embo Rep, 2010
Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization.
Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.
Schneider et al., Trieste, Italy. In J Biol Chem, 2010
hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel.
hGTSE-1 expression stimulates cytoplasmic localization of p53.
Schneider et al., Trieste, Italy. In J Biol Chem, 2004
requires an intact nuclear export signal and functional Mdm2 for the regulation of p53
DP-b99 (D-Pharm).
Yeung, Halifax, Canada. In Curr Opin Investig Drugs, 2004
DP-b99 is a derivative of the calcium chelator BAPTA that is under development as a neuroprotectant for the potential treatment of stroke, head trauma and neurological damage associated with coronary artery bypass graft.
The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.
Schneider et al., Trieste, Italy. In J Biol Chem, 2003
GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function
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