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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Icos ligand

B7RP-1, ICOSL, ICOS ligand, B7h, B7-H2
Top mentioned proteins: ICOS, CD28, CD4, CD80, CD86
Papers on B7RP-1
Development of a Novel Functional Monoclonal Antibody to Human CD275: Characterization and Biological Activity.
New
Zhang et al., Suzhou, China. In Monoclon Antib Immunodiagn Immunother, Feb 2016
UNASSIGNED: CD275 (B7-H2, ICOSL), a co-stimulatory molecule of the B7 superfamily, plays a critical role in immune response.
The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.
New
Stumhofer et al., Little Rock, United States. In J Immunol, Feb 2016
Moreover, treatment of mice with anti-ICOS ligand Abs to modulate ICOS-ICOS ligand signaling revealed a requirement for ICOS in TFH differentiation only after day 6 postinfection.
Regulation of Immunity by Butyrophilins.
New
Impact
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276).
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Review
New
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
In addition, ILC2 function is also influenced by inducible T cell costimulator (ICOS)/ICOS-ligand (ICOS-L) interactions via direct contact between immune cells.
[Dynamic alteration of CD154/CD40 and its effects on Th1/Th2 polarization in inducible co-stimulator ligand knockout mice infected with Schistosoma japonicum].
New
Xia et al., Huainan, China. In Beijing Da Xue Xue Bao, Jan 2016
OBJECTIVE: To analyze effect on the CD154-CD40 signaling pathway and Th1/Th2 polarization by deficient inducible co-stimulator (ICOS)-ICOS ligand (ICOSL) signaling in mice infected with Schistosoma japonicum.
Association of polymorphisms in the ICOS and ICOSL genes with the pathogenesis of autoimmune thyroid diseases.
New
Iwatani et al., Ōsaka, Japan. In Endocr J, Dec 2015
Inducible co-stimulator (ICOS) (CD278) and co-stimulator ligand (ICOSL) (CD275) are important costimulatory molecules.
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Aug 2015
Unexpectedly, ILC2-intrinsic IL-33 activation was required for Treg cell accumulation in vivo and was independent of ILC2 type 2 cytokines but partially dependent on direct co-stimulatory interactions via ICOSL-ICOS.
Local triggering of the ICOS coreceptor by CD11c(+) myeloid cells drives organ inflammation in lupus.
New
Impact
Shlomchik et al., Bonn, Germany. In Immunity, Apr 2015
Here we show that selective ablation of ICOS ligand (ICOSL) in CD11c(+) cells, but not in B cells, dramatically ameliorates kidney and lung inflammation in lupus-prone MRL.Fas(lpr) mice.
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.
New
Impact
Hedrick et al., San Diego, United States. In Immunity, Mar 2015
We report that ICOS signaling inactivates the transcription factor FOXO1, and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand.
T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction.
New
Impact
Qi et al., Beijing, China. In Nature, Feb 2015
Using competitive mixed chimaera, we show here that, beyond the role in promoting TFH development, ICOSL (inducible T-cell co-stimulator ligand, also known as ICOSLG) is important for individual B cells to competitively participate in the GC reaction and to develop into BMPCs.
Increased circulating follicular helper T cells with decreased programmed death-1 in chronic renal allograft rejection.
Xia et al., Changzhou, China. In Bmc Nephrol, 2014
METHODS: The frequency of Tfh, B cells and the levels of their alloimmune-regulating molecules including chemokine receptor type 5 (CXCR5), inducible T cell co-stimulator (ICOS), programmed death-1 (PD-1), ICOSL, PDL-1 and interleukin-21 (IL-21), of peripheral blood were comparatively measured in 42 primary renal allograft recipients within 1-3 years after transplantation.
Effect of TACI signaling on humoral immunity and autoimmune diseases.
Review
Tao et al., Wuhan, China. In J Immunol Res, 2014
The mechanisms underlying these effects probably involve changed expressions of some crucial molecules, such as B lymphocyte induced maturation protein-1 (Blimp-1) and inducible T-cell costimulator ligand (ICOSL) in B cells and/or plasma cells.
Mechanistic effects of IVIg in neuroinflammatory diseases: conclusions based on clinicopathologic correlations.
Review
Dalakas, Athens, Greece. In J Clin Immunol, 2014
In repeated muscle biopsies of IBM patients who did not respond to IVIg, the mRNA or protein expression for chemokines, IFN-γ, TGF-ß, IL-10, Ubiquitin and aB-crystallin is reduced, but not for the key molecules ICOS, ICOSL, IL-6, IL1-β, perforin, APP, nitric oxide synthase and nitrotyrosine, in spite of good IVIg penetration in muscles.
The targeting of β-cells by T lymphocytes in human type 1 diabetes: clinical perspectives.
Review
Boitard et al., Paris, France. In Diabetes Obes Metab, 2013
We report here the role of genes encoding co-activation molecules involved in the activation of T lymphocytes, ICOS and ICOS ligand (B7RP1).
Co-stimulatory molecules as targets for treatment of lupus.
Review
Merrill, Oklahoma City, United States. In Clin Immunol, 2013
To date biologics which provide direct blockade of interactions between CD40 and CD154, B7RP-1 and ICOS, and CD80 or CD86 with CD28 have been assessed in multicenter clinical trials.
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation.
GeneRIF
Waibler et al., Langen, Germany. In Blood, 2012
A model of positive feedback conferred by ICOS-LICOS interaction between TGN1412-treated T cells and endothelial cells.
Expression of ICOSLG on mouse hematologic neoplasm cell lines and their influence on cytotoxicity in allogeneic mixed lymphocyte reactions.
GeneRIF
Wang et al., Shanghai, China. In Leuk Lymphoma, 2012
Results indicate that ICOSLG blockade may enhance cytotoxity in allogeneic mixed lymphocyte-hematologic neoplasm cell reactions.
Lipopolysaccharide mediated mast cells induce IL-10 producing regulatory T cells through the ICOSL/ICOS axis.
GeneRIF
Shen et al., Shanghai, China. In Clin Immunol, 2012
Induction of IL-10 producing regulatory T cells mainly relied on the inducible costimulator ligand (ICOSL)/ICOS axis
Inhibition of T-cell expansion caused by inducible costimulator/B7h costimulation blockade in direct allorecognition pathway.
GeneRIF
Yu et al., Beijing, China. In Transplant Proc, 2011
ICOS/B7h signal plays an important role in direct allorecognition, eliciting allogeneic responses in vitro.
Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development.
GeneRIF
Sun et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
Findings suggest that the noncanonical NF-kappaB pathway regulates the development of Tfh cells by mediating ICOSL gene expression in B cells.
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