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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-set domain containing T cell activation inhibitor 1

B7-H4, B7x
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: H4, PD-L1, B7-H3, CAN, H1
Papers on B7-H4
Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.
New
Savinov et al., Sioux Falls, United States. In J Immunol, Feb 2016
Recently, we demonstrated that the phenotype of impaired negative costimulation, due to reduced levels of V-set domain-containing T cell activation inhibitor 1 (VTCN1) protein on APCs, is shared between diabetes-susceptible NOD mice and human T1D patients.
Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide.
New
Zhang et al., Harbin, China. In Mol Med Report, Feb 2016
UNASSIGNED: Arsenic trioxide (As2O3; ATO), a compound which is characterized by its ability to function as a potent anticancer agent, has been investigated in a variety of carcinomas.
Prognostic investigations of B7-H1 and B7-H4 expression levels as independent predictor markers of renal cell carcinoma.
New
Ahmadi et al., Tehrān, Iran. In Tumour Biol, Jan 2016
UNASSIGNED: In order to evaluate the correlation of B7-H4 and B7-H1 with renal cell carcinoma (RCC), we analyzed B7-H1 and B7-H4 expressions and their clinical significance by immunohistochemical method.
Expression of immune checkpoint molecules in endometrial carcinoma.
New
Che et al., Zhengzhou, China. In Exp Ther Med, Nov 2015
The present study aimed to analyze the expression levels of indoleamine 2,3-dioxygenase (IDO), programmed death-ligand (PD-L) 1, PD-L2, B7-H4, galectin-1 and galectin-3 in tissue samples from patients with endometrial carcinoma, in order to detect the immunosuppressive environment of endometrial carcinomas.
Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma.
New
Shan et al., Shijiazhuang, China. In Tumour Biol, Oct 2015
UNASSIGNED: The coinhibitory molecules, B7-H3 and B7-H4, have shown negative regulation in T cell activation and tumor-associated macrophage (TAM) polarization in tumor-specific immunity.
B7-H4 as a protective shield for pancreatic islet beta cells.
Review
Warnock et al., Vancouver, Canada. In World J Diabetes, 2015
An attractive approach is offered by the newly-identified negative T cell co-signaling molecule B7-H4 which is expressed in normal human islets, and its expression co-localizes with insulin.
Circulating B7-H4 in serum predicts prognosis in patients with hepatocellular carcinoma.
Li et al., Fuzhou, China. In Genet Mol Res, 2014
B7-H4 is member of the B7 family that negatively regulates the immune response, which are important for fine-tuning of the tumor microenvironment.
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy.
Review
Suh et al., Montréal, Canada. In Immune Netw, 2014
Murine tumor models have provided significant support for the targeting of multiple immune checkpoints involving CTLA-4, PD-1, ICOS, B7-H3 and B7-H4 during tumor growth, and clinical studies investigating the therapeutic effects of CTLA-4 and PD-1 blockade have shown exceptionally promising results in patients with advanced melanoma and other cancers.
Novel Immune Check-Point Regulators in Tolerance Maintenance.
Review
Wang et al., Palo Alto, United States. In Front Immunol, 2014
In this review, we discuss the function of newly identified B7 family molecules, B7-H4 and V-domain Ig Suppressor of T cell Activation (VISTA), and the butyrophilin/butyrophilin-like family members.
[Research progress of negative costimulator B7-H4 in urologic tumors].
Review
Hong et al., Lanzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2014
B7-H4 is a recently-identified member of B7 costimulation superfamily.
B7-H4 as a potential target for immunotherapy for gynecologic cancers: a closer look.
Review
Powell et al., Philadelphia, United States. In Gynecol Oncol, 2014
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production.
The immunohistochemical analysis of antigens such as RCAS1 and B7H4 in the cervical cancer nest and within the fibroblasts and macrophages infiltrating the cancer microenvironment.
GeneRIF
Wicherek et al., Kraków, Poland. In Am J Reprod Immunol, 2012
The intensity of the suppressive profile of the cervical cancer microenvironment indicated by the presence of both RCAS1 and B7H4 on the front of the tumor and in the macrophages and fibroblasts infiltrating the cancer stroma
Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: a potential mechanism of immune escape.
GeneRIF
Huang et al., Suzhou, China. In Cancer Lett, 2012
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.
Novel genetic association of the VTCN1 region with rheumatoid arthritis.
GeneRIF
Toes et al., Leiden, Netherlands. In Ann Rheum Dis, 2012
These results indicate a novel genetic association with the VTCN1 region in rheumatoid arthritis susceptibility.
Enhanced T cell immunity by B7-H4 downregulation in nonsmall-cell lung cancer cell lines.
GeneRIF
Huang et al., Nanjing, China. In J Int Med Res, 2011
study concludes B7-H4 negatively regulates T cell-mediated antitumour immunity in nonsmall-cell lung cancer
The inhibitory role of b7-h4 in antitumor immunity: association with cancer progression and survival.
Review
GeneRIF
Sun et al., Harbin, China. In Clin Dev Immunol, 2010
paper summarizes the pertinent data on the inhibitory role of B7-H4 in antitumor immunity and its association with cancer progression and survival [review]
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.
Impact
Murphy et al., Saint Louis, United States. In Nat Immunol, 2005
Previously, indirect observations suggested that B7x was a ligand for BTLA.
The B7 family revisited.
Review
Impact
Sharpe et al., Boston, United States. In Annu Rev Immunol, 2004
The five new B7 family members, ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1) are expressed on professional antigen-presenting cells as well as on cells within nonlymphoid organs, providing new means for regulating T cell activation and tolerance in peripheral tissues.
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Impact
Murphy et al., Saint Louis, United States. In Nat Immunol, 2003
B7x, a peripheral homolog of B7, is a ligand of BTLA.
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Impact
GeneRIF
Chen et al., Rochester, United States. In Immunity, 2003
May participate in negative regulation of cell-mediated immunity in peripheral tissues
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