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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

CD276 molecule

B7-H3, CD276
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: PD-L1, HAD, B7-H4, H1, CAN
Papers on B7-H3
B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
New
Hua et al., Wuxi, China. In Tumour Biol, Feb 2016
UNASSIGNED: B7-H3, a member of the B7 family, has been reported to be highly expressed in colorectal cancer and is associated with poor prognosis and overall survival.
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors.
New
Fodstad et al., Oslo, Norway. In Oncotarget, Feb 2016
We have used human triple-negative breast cancer cell lines with different expression levels of B7-H3 to evaluate its effects on the sensitivity to 22 different anticancer compounds in a drug screen.
Regulation of Immunity by Butyrophilins.
New
Impact
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276).
Preferential induction of the T cell auxiliary signaling molecule B7-H3 on synovial monocytes in rheumatoid arthritis.
New
Lee et al., Tokyo, Japan. In J Biol Chem, Jan 2016
UNASSIGNED: B7-H3, a newly identified B7 family member, has functional duality as a costimulator and coinhibitor that fine-tunes T-cell mediated immune responses.
B7-H3 overexpression in oral cancer.
New
P Leme et al., Piracicaba, Brazil. In Oral Dis, Jan 2016
UNASSIGNED: In a recent study published in Proceedings of the National Academy of Sciences of the United States of America, Chen and collaborators (2015), aiming to discover predictive markers with impact on treatment and survival of patients with oral squamous cell carcinoma (OSCC), described an important role of the transmembrane receptor B7 homolog 3 (B7-H3), also known as CD276 and B7RP-2, in OSCCs.
[Research Progress on Co-stimulating Molecule B7-H3 in Hematological Malignancies].
Review
New
Ke et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
Costimulatory molecule B7-H3 is a new member of the B7 immunoregulatory family identified in 2001.
Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphisms with Schizophrenia in Chinese Han Population.
Yue et al., Beijing, China. In Plos One, 2014
Moreover, 12 genes (HLA-A, HLA-C, HLA-DOB, HLA-DPB1, HLA-DQA2, HLA-DRB1, MPZ, CD276, NLGN1, NRCAM, CLDN1 and ICAM3) were modestly significantly associated with schizophrenia (P<0.01).
The CD28-B7 Family in Anti-Tumor Immunity: Emerging Concepts in Cancer Immunotherapy.
Review
Suh et al., Montréal, Canada. In Immune Netw, 2014
Murine tumor models have provided significant support for the targeting of multiple immune checkpoints involving CTLA-4, PD-1, ICOS, B7-H3 and B7-H4 during tumor growth, and clinical studies investigating the therapeutic effects of CTLA-4 and PD-1 blockade have shown exceptionally promising results in patients with advanced melanoma and other cancers.
B7-H3-mediated tumor immunology: Friend or foe?
Review
Shan et al., Shijiazhuang, China. In Int J Cancer, 2014
B7-H3 (CD276), a newly identified member of the B7 family of molecules, is often induced in human tumors and its overexpression is closely correlated with survival, prognosis or tumor grade.
Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches.
Review
Castriconi et al., Genova, Italy. In Front Immunol, 2013
PVR (Poliovirus Receptor) and B7-H3 are promising targets, since they are expressed by most high-risk NB, are upregulated in tumor vasculature and are essential for tumor survival/invasiveness.
Targeting the B7 family of co-stimulatory molecules: successes and challenges.
Review
Miller et al., Chicago, United States. In Biodrugs, 2013
Examples of the more recently identified B7/CD28 family members are PD-L1, PD-L2, inducible co-stimulatory molecule-ligand (ICOS-L), B7-H3, and B7-H4, all of which may emerge as potential fusion protein therapeutics, each with unique, yet often overlapping functions.
B7-H3 participates in the development of experimental pneumococcal meningitis by augmentation of the inflammatory response via a TLR2-dependent mechanism.
GeneRIF
Feng et al., Suzhou, China. In J Immunol, 2012
Exogenous administration of B7-H3 strongly amplifies the inflammatory response, exacerbates blood-brain barrier disruption, and aggravates the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN wild-type mice.
Immunoexpression of B7-H3 in endometrial cancer: relation to tumor T-cell infiltration and prognosis.
GeneRIF
Brustmann et al., Vienna, Austria. In Gynecol Oncol, 2012
B7-H3 expression on cancer cells is correlated with the number of T cells infiltrating the tumor. Endometrium tumor development and progression may be associated with downregulation of T-cell-mediated antitumor immunity through B7-H3.
Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.
GeneRIF
Wang et al., Beijing, China. In J Viral Hepat, 2012
The reduced expression of B7-H3 in the livers might temper the inhibition of T-cell responses mediated by B7-H3 expressed on hepatocytes and thus promote the hepatic inflammation and hepatitis progression in the chronic HBV-infected patients.
Stimulation of B7-H3 (CD276) directs the differentiation of human marrow stromal cells to osteoblasts.
GeneRIF
Zhang et al., Suzhou, China. In Immunobiology, 2011
regulates differentiation of bone marrow stromal cells to osteoblasts
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Impact
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
Expression and regulation of B7-H3 immunoregulatory receptor, in human mesothelial and mesothelioma cells: immunotherapeutic implications.
GeneRIF
Maio et al., Siena, Italy. In J Cell Physiol, 2011
Analysis of B7-H3 protein expression indicates that comparable levels of B7-H3 are expressed on both primary human mesothelial and malignant mesothelial cell types.
The B7 family revisited.
Review
Impact
Sharpe et al., Boston, United States. In Annu Rev Immunol, 2004
The five new B7 family members, ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1) are expressed on professional antigen-presenting cells as well as on cells within nonlymphoid organs, providing new means for regulating T cell activation and tolerance in peripheral tissues.
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.
Impact
GeneRIF
Mak et al., Toronto, Canada. In Nat Immunol, 2003
preferentially down-regulates t helper type 1-mediated immune responses
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
Impact
Chen et al., Rochester, United States. In Nat Immunol, 2001
We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family members.
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