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NEDD4 binding protein 2
B3BP, BCL-3-binding protein, Nedd4-binding protein 2
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. [provided by RefSeq, Jul 2008] (from
Folkers et al., Utrecht, Netherlands. In J Mol Biol, 2008
The solution structure of the functionally active Smr domain of the Bcl3-bindingprotein (also known as Nedd4-bindingprotein2), a protein with unknown function that lacks other domains present in MutS proteins, is determined.