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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal-regulatory protein alpha

B it, SHPS-1, SIRPalpha, CD172a, SIRP
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD47, SHP1, NS1, Src, CAN
Papers using B it antibodies
Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression
Supplier
Moestrup Søren K et al., In Molecular Therapy, 2010
... the Lighting LINK PerCP Conjugation Kit (Innova Bioscience, Cambridge, UK), anti-rat CD4-APC (Invitrogen), and anti-rat CD172a-PE (ED-9) (AbD Serotec)(0.2–0.5 µg) in 100 µl PBS pH ...
TIMP-2 is required for efficient activation of proMMP-2 in vivo
Supplier
Clemmons David R. et al., In Experimental Diabetes Research, 1999
... The anti-SHPS-1 antibody was purchased from Upstate Cell Signaling Solutions (Charlottesville, VA) ...
Papers on B it
Beneficial Effects of CpG-Oligodeoxynucleotide Treatment on Trauma and Secondary Lung Infection.
New
Lederer et al., München, Germany. In J Immunol, Feb 2016
We found increased expression of CD14, CD64, and PD-L1 on F4-80(+) and F4-80(+)CD11c(+) macrophages, CD11c(+) dendritic cells, and CD14(+)CD172a(+) cells after burn-injury and infection, supporting previous reports of innate immune cell activation in sepsis.
Innate Immune Response of the Pig Laryngeal Mucosa to Endotracheal Intubation.
New
Birchall et al., London, United Kingdom. In Otolaryngol Head Neck Surg, Jan 2016
Based on quantitative immunohistochemistry, percentage areas of positive staining for CD172a, CD163, MHC class II, CD14, and CD16 were calculated separately for the epithelium and lamina propria of each biopsy.
Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs.
New
Sangild et al., Frederiksberg, Denmark. In Innate Immun, Jan 2016
Neutrophils gradually matured after preterm birth with increasing CD14 and decreasing CD172a expressions.
Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance.
New
Zhao et al., Wuhan, China. In Small, Dec 2015
Biomimetic RBC membrane-coated Fe3 O4 nanoparticles (Fe3 O4 @RBC NPs) rely on CD47, which is a "don't eat me" marker on the RBC surface, to escape immune clearance through interactions with the signal regulatory protein-alpha (SIRP-α) receptor.
The Trojan Horse Tale Revisited: An Eye on Metastatic Spread of Carcinoma Cells.
New
Heindl et al., Köln, Germany. In Cancer Immunol Res, Dec 2015
These Ber-EP4-expressing cells exhibited a monocytic-myeloid phenotype with coexpression of CD11b, CD115, and the macrophage marker CD172a (SIRP-α).
Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon.
New
Jing et al., Kunming, China. In Immunol Res, Nov 2015
Signal regulator protein α (SIRP-α) plays an important role in negative regulation of innate immunity.
SIRP/CD47 signaling in neurological disorders.
Review
New
Hu et al., Pittsburgh, United States. In Brain Res, Nov 2015
This review will focus on the signal regulatory protein (SIRP) and its ligand CD47, two surface receptors expressed on microglia and other cells in the central nervous system (CNS) such as neurons.
The immunology of the porcine skin and its value as a model for human skin.
Review
New
Ricklin et al., Switzerland. In Mol Immunol, Jul 2015
The equivalent of the human CD141(+) DC subset is CD1a(-)CD4(-)CD172a(-)CADM1(high), that of the CD1c(+) subset is CD1a(+)CD4(-)CD172a(+)CADM1(+/low), and porcine plasmacytoid dendritic cells are CD1a(-)CD4(+)CD172a(+)CADM1(-).
The CD47-SIRPα signalling system: its physiological roles and therapeutic application.
Review
Matozaki et al., Kōbe, Japan. In J Biochem, 2014
Signal regulatory protein α (SIRPα), also known as SHPS-1/BIT/ CD172a, is an immunoglobulin superfamily protein that binds to the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region.
The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target.
Review
Impact
Van den Berg et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPα (also termed CD172a or SHPS-1).
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.
Impact
Discher et al., Philadelphia, United States. In Science, 2013
The membrane protein CD47 is reportedly a "marker of self" in mice that impedes phagocytosis of self by signaling through the phagocyte receptor CD172a.
Mechanisms tagging senescent red blood cells for clearance in healthy humans.
Review
Bogdanova et al., Zürich, Switzerland. In Front Physiol, 2012
Exoplasmically accessible phosphatidylserine (PS) and the alterations in the interplay between CD47 on RBC and its receptor on macrophages, signal regulatory protein alpha (SIRPalpha protein), were also reported to induce erythrocyte clearance.
SIRPα interacts with nephrin at the podocyte slit diaphragm.
GeneRIF
Igarashi et al., Tokyo, Japan. In Febs J, 2012
In the glomeruli of CNS patients carrying mutations in NPHS1, where SD formation is disrupted, the expression of SIRPalpha as well as Neph1 and nephrin was significantly decreased, indicating that SIRPalpha is closely associated with the nephrin complex
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein α (SIRPα), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein β (SIRPβ).
GeneRIF
Parkos et al., Atlanta, United States. In J Biol Chem, 2012
Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein alpha (SIRPalpha), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein beta (SIRPbeta).
SIRPα/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen.
GeneRIF
Fingeroth et al., Boston, United States. In J Immunol, 2012
SIRPalpha/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen.
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
GeneRIF
Weissman et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
data, taken together with similar findings with other human neoplasms, show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor phagocytosis and elimination
[The expression and significance of signal regulatory protein a1 in autoimmune hepatitis].
GeneRIF
Liu et al., Weihai, China. In Zhonghua Gan Zang Bing Za Zhi, 2011
SIRPalpha1 in hepatic sinusoid Kupffer cells is associated with the extent of autoimmune hepatitis.
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.
Impact
Weissman et al., Stanford, United States. In Cell, 2009
Cell-surface CD47 interacts with its receptor on macrophages, SIRPalpha, to inhibit phagocytosis of normal, healthy cells.
The counterbalance theory for evolution and function of paired receptors.
Impact
Hatherley et al., Oxford, United Kingdom. In Immunity, 2008
We evaluate recent structural data on SIRPalpha (signal regulatory protein) and LILRB1 (leukocyte immunoglobulin-like receptor subfamily B member 1) showing evidence of pathogen pressure in nonligand-binding regions of these receptors together with data on pathogen binding to PIRs (paired Ig-like receptors) to provide support for this theory.
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.
Impact
Danska et al., Toronto, Canada. In Nat Immunol, 2007
NOD SIRP-alpha showed enhanced binding to the human CD47 ligand, and its expression on mouse macrophages was required for support of human hematopoiesis.
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