SIRP/CD47 signaling in neurological disorders.
Pittsburgh, United States. In Brain Res, Nov 2015
This review will focus on the signal regulatory protein (SIRP) and its ligand CD47, two surface receptors expressed on microglia and other cells in the central nervous system (CNS) such as neurons.
SIRPα interacts with nephrin at the podocyte slit diaphragm.
Tokyo, Japan. In Febs J, 2012
In the glomeruli of CNS patients carrying mutations in NPHS1, where SD formation is disrupted, the expression of SIRPalpha as well as Neph1 and nephrin was significantly decreased, indicating that SIRPalpha is closely associated with the nephrin complex
The counterbalance theory for evolution and function of paired receptors.
Oxford, United Kingdom. In Immunity, 2008
We evaluate recent structural data on SIRPalpha (signal regulatory protein) and LILRB1 (leukocyte immunoglobulin-like receptor subfamily B member 1) showing evidence of pathogen pressure in nonligand-binding regions of these receptors together with data on pathogen binding to PIRs (paired Ig-like receptors) to provide support for this theory.