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Cysteine-serine-rich nuclear protein 1

AXUD1, CSRNP1, Taip3, AXIN1 up-regulated
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Axin, HAD, Interleukin-2, PrP, G1P3
Papers on AXUD1
Compression of human primary cementoblasts leads to apoptosis: A possible cause of dental root resorption?
Erber et al., Heidelberg, Germany. In J Orofac Orthop, 2014
There is evidence from genome-wide expression analysis (Illumina HumanHT-12 v4 Expression BeadChip Kit; > 30,000 genes) that apoptotic processes are upregulated after the compression of cementoblasts, which is particularly true of the pro-apoptotic gene AXUD1.
Gene expression profile of compressed primary human cementoblasts before and after IL-1β stimulation.
Erber et al., Heidelberg, Germany. In Clin Oral Investig, 2014
Prominent gene expression alterations (COX2, AXUD1, FOSB, CCL2, IFI6, and PTGES) were verified by quantitative RT-PCR (qRT-PCR) in two HPCB populations.
[AXIN1-related CSRNP1 mRNA expression and its transcriptional regulation in TGF-β1-induced tumor cells].
Zeng et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2013
OBJECTIVE: To investigate AXIN1-related CSRNP1 gene expression and the mechanism of its transcriptional regulation in TGF-β1-induced tumor cells.
Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma.
Zhang et al., Changsha, China. In Oncol Rep, 2013
Three genes, GNAT1, SEMA3B and AXUD1, with low or no expression in OSCC tissues and the cell line TCA8113 were selected, and the promoter methylation status was further analyzed by methylation-specific PCR (MS-PCR).
Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafish.
Glavic et al., Santiago, Chile. In Dev Dyn, 2009
Phylogenetic examination shows that axud1 is likely to be the ortholog of the only member of this family present in Drosophila, as well as to the previously described mouse CSRNP1 and to human AXUD1 (Axin upregulated-1).
Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity.
de Celis et al., Santiago, Chile. In Mech Dev, 2009
Analysis of human cancer cells with mutation in AXIN gene has uncovered the potential function of AXUD1 as a tumour suppressor.
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).
Ihle et al., Memphis, United States. In Plos One, 2006
Our studies identified an immediate early gene that is strongly induced in response to IL-2 in mouse T cells which we named cysteine- serine-rich nuclear protein-1 (CSRNP-1).
Transcriptional analysis of doxorubicin-induced cardiotoxicity.
Shohet et al., Dallas, United States. In Am J Physiol Heart Circ Physiol, 2006
These include STARS, a hypertrophy-responsive gene; SNF1-kinase, a potential modulator of ATP levels; and AXUD1, a downstream target of the proapoptotic regulator AXIN1.
Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney.
Furukawa et al., Tokyo, Japan. In Oncogene, 2001
Among the genes showing altered expression, we focused on one, termed AXUD1 (AXIN1 up-regulated), that revealed enhanced expression in response to exogenously expressed AXIN1 but not to LacZ, a control gene.
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