Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.
Lucknow, India. In Tumour Biol, Jan 2016
In this study, we assessed the association of common germline variants of Wnt pathway genes (SFRP2, SFRP4, DKK2, DKK3, WISP3, APC, β-catenin, AXIN-2, GLI-1) to evaluate their contribution in predisposition to GBC and treatment outcomes.
The roles of AXIN2 in tumorigenesis and epigenetic regulation.
Changchun, China. In Fam Cancer, Jun 2015
AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on.
Genetic basis of dental agenesis--molecular genetics patterning clinical dentistry.
Delhi, India. In Med Oral Patol Oral Cir Bucal, 2014
To date, the mutation spectra of non-syndromic form of familial and sporadic tooth agenesis in humans have revealed defects in various such genes that encode transcription factors, MSX1 and PAX9 or genes that code for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1).
Genetic background of nonsyndromic oligodontia: a systematic review and meta-analysis.
Gießen, Germany. In J Orofac Orthop, 2013
All these genes vary both in terms of number of identified mutations and in terms of number of documented patients: 33 mutations and 93 patients are on record for PAX9, 10 mutations and 51 patients for EDA, 12 mutations and 33 patients for MSX1, 6 mutations and 17 patients for AXIN2, and 1 mutation in 1 patient for EDARADD, NEMO, and KRT17 each.