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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Axin 2

AXIN2, conductin
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: APC, Axin, CAN, MSX1, PAX9
Papers using AXIN2 antibodies
The antitumor activity of the fungicide ciclopirox
Supplier
Virshup D M et al., In Oncogene, 2009
... Antibodies to axin2 were from Cell Signaling (Danvers, MA, USA) ...
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.
Supplier
Mei Lin, In PLoS ONE, 2007
... Polyclonal anti-phospho-LRP6 (Ser1490) and anti-Dvl2 and monoclonal anti-Axin2 were purchased from Cell Signaling Technology ...
The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.
Supplier
Hotchin Neil A., In PLoS ONE, 2004
... AXIN1 and AXIN2 were detected with rabbit monoclonal antibodies C95H11 and 76G6, respectively (Cell Signaling Technology) ...
Papers on AXIN2
AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth.
New
Goldkorn et al., Philadelphia, United States. In Prostate, Feb 2016
Of these, low AXIN2 expression was internally validated in the discovery cohort.
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
To detect changes in canonical Wnt/β-catenin signaling occurring within the cornea epithelium, axin2 expression was measured over the course of regeneration.
Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.
New
Mittal et al., Lucknow, India. In Tumour Biol, Jan 2016
In this study, we assessed the association of common germline variants of Wnt pathway genes (SFRP2, SFRP4, DKK2, DKK3, WISP3, APC, β-catenin, AXIN-2, GLI-1) to evaluate their contribution in predisposition to GBC and treatment outcomes.
Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.
New
Buchsbaum et al., Birmingham, United States. In Lab Invest, Jan 2016
Expression of R-spondin 2 (RSPO2), RSPO3, PORCN, WLS, AXIN2, and three previously characterized RSPO fusion transcripts were assessed using Taqman assays.
Wnt/βcatenin-signaling and the formation of Müller glia-derived progenitors in the chick retina.
New
Fischer et al., United States. In Dev Neurobiol, Jan 2016
In NMDA-damaged retinas where MGPCs are known to form, we find dynamic changes in retinal levels of potential readouts of Wnt-signaling, including dkk1, dkk3, axin2, c-myc, tcf-1 and cd44.
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia.
New
Lin et al., Shanghai, China. In Sci Rep, Dec 2015
We scanned another female with non-syndromic anodontia and her younger brother with the same gene mutations of the PAX9,MSX1,AXIN2 and EDA, but without developmental abnormalities in the dentition.
Novel PAX9 gene polymorphisms and mutations and susceptibility to tooth agenesis in the Czech population.
New
In Neuro Endocrinol Lett, Dec 2015
Among genes involved in tooth morphogenesis, mutations in PAX9, MSX1, AXIN2, WNT10a, and EDA genes have been associated with tooth agenesis.
The roles of AXIN2 in tumorigenesis and epigenetic regulation.
Review
New
Liu et al., Changchun, China. In Fam Cancer, Jun 2015
AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on.
AXIN1 and AXIN2 variants in gastrointestinal cancers.
Review
Fearon et al., Ann Arbor, United States. In Cancer Lett, 2015
The AXIN1 and AXIN2 proteins function in the canonical Wnt pathway, and AXIN1/2 alterations have been proposed as key defects in some cancers.
The role of CDX2 in inflammatory bowel disease.
Review
Coskun, Denmark. In Dan Med J, 2014
The role of CDX2 in the transcriptional regulation of MEP1A and the β-catenin degradation complex genes APC, AXIN2, and GSK3β were investigated in Caco-2 cells.
Genetic basis of dental agenesis--molecular genetics patterning clinical dentistry.
Review
Chhabra et al., Delhi, India. In Med Oral Patol Oral Cir Bucal, 2014
To date, the mutation spectra of non-syndromic form of familial and sporadic tooth agenesis in humans have revealed defects in various such genes that encode transcription factors, MSX1 and PAX9 or genes that code for a protein involved in canonical Wnt signaling (AXIN2), and a transmembrane receptor of fibroblast growth factors (FGFR1).
Genetic background of nonsyndromic oligodontia: a systematic review and meta-analysis.
Review
Jabir et al., Gießen, Germany. In J Orofac Orthop, 2013
All these genes vary both in terms of number of identified mutations and in terms of number of documented patients: 33 mutations and 93 patients are on record for PAX9, 10 mutations and 51 patients for EDA, 12 mutations and 33 patients for MSX1, 6 mutations and 17 patients for AXIN2, and 1 mutation in 1 patient for EDARADD, NEMO, and KRT17 each.
Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity.
GeneRIF
Weiss et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2012
Axin2 acts as a potent promoter of carcinoma behavior by up-regulating the activity of the transcriptional repressor, Snail1, inducing a functional epithelial-mesenchymal transition (EMT) program and driving metastatic activity
Association of AXIN2 with non-syndromic oral clefts in multiple populations.
GeneRIF
Silva et al., Houston, United States. In J Dent Res, 2012
results continue to support a role for AXIN2 in the etiology of human clefting
Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20.
GeneRIF
Behrens et al., Erlangen, Germany. In Embo Rep, 2012
CDC20-mediated degradation of conductin regulates Wnt/beta-catenin signalling for maximal activity during G1/S.
Gone with the Wnt: the canonical Wnt signaling axis is present and androgen dependent in the rodent gubernaculum.
GeneRIF
Hutson et al., Melbourne, Australia. In J Pediatr Surg, 2011
Axin2 expression in the E19 gubernaculum confirms canonical Wnt pathway activation. Its absence in the core of flutamide-treated gubernacula indicates Wnt down-regulation
Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.
GeneRIF
Smith et al., Cambridge, United Kingdom. In Plos One, 2011
Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos.
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.
Impact
Peltomäki et al., Helsinki, Finland. In J Clin Oncol, 2005
The AXIN2 gene was screened for mutations by sequencing.
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.
Impact
Baylin et al., Baltimore, United States. In Nat Genet, 2004
It occurs through mutations mainly of APC and less often of CTNNB1 (encoding beta-catenin) or AXIN2 (encoding axin-2, also known as conductin).
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.
Impact
Birchmeier et al., Berlin, Germany. In Science, 1998
Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC).
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