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Axin 1

Axin, Kinky, AXIN1
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: APC, CAN, TCF, PKI, AML1
Papers using Axin antibodies
Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2
Malbon Craig C et al., In Journal of Molecular Signaling, 1998
... from Abcam (Cambridge, MA); polyclonal anti-phospho-serine antibody from Zymed Laboratories (South San Francisco, CA); a second anti-Axin antibody from R&D systems (Minneapolis, MN); Ni-NTA resin from Qiagen (Valencia, CA); glutathione-coupled agarose ...
Papers on Axin
Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.
Bossé et al., Québec, Canada. In Am J Cardiol, Mar 2016
Nine genes previously associated with BAV (NOTCH1, AXIN1, EGFR, ENG, GATA5, NKX2-5, NOS3, PDIA2, and TGFBR2) were sequenced in 48 patients with BAV using the Ion Torrent Personal Genome Machine.
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
Krappmann et al., München, Germany. In Oncogene, Feb 2016
By a proteomic approach we identified recruitment of β-catenin and its destruction complex consisting of APC, AXIN1, CK1α and GSK3β to oncogenic CARMA1.
The TDP-43 N-Terminal Domain Structure at High Resolution.
Laurents et al., Madrid, Spain. In Febs J, Feb 2016
The fold is topologically similar to the reported structure of Axin 1.
Association of Wnt signaling pathway genetic variants in gallbladder cancer susceptibility and survival.
Mittal et al., Lucknow, India. In Tumour Biol, Jan 2016
In this study, we assessed the association of common germline variants of Wnt pathway genes (SFRP2, SFRP4, DKK2, DKK3, WISP3, APC, β-catenin, AXIN-2, GLI-1) to evaluate their contribution in predisposition to GBC and treatment outcomes.
Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures.
Stefansson et al., Reykjavík, Iceland. In Nat Commun, Dec 2015
Additional new BMD signals were also found at the AXIN1 and SOST loci and a new lead SNP at the EN1 locus.
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
Llovet et al., Paris, France. In Gastroenterology, Oct 2015
TP53 and CTNNB1 are the next most prevalent mutations, affecting 25%-30% of HCC patients, that, in addition to low-frequency mutated genes (eg, AXIN1, ARID2, ARID1A, TSC1/TSC2, RPS6KA3, KEAP1, MLL2), help define some of the core deregulated pathways in HCC.
Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma.
Lu et al., Beijing, China. In World J Gastroenterol, Jun 2015
APC and AXIN1 were mutated in HCC.
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Zucman-Rossi et al., Paris, France. In Nat Genet, May 2015
Associations of mutations defined 3 groups of genes related to risk factors and centered on CTNNB1 (alcohol), TP53 (hepatitis B virus, HBV) and AXIN1.
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Xu et al., Seattle, United States. In Nature, Feb 2015
Recent studies have shown that PARylation can serve as a signal for the polyubiquitination and degradation of several crucial regulatory proteins, including Axin and 3BP2 (refs 7, 8, 9).
Emerging roles of Axin in cerebral cortical development.
Ip et al., Hong Kong, Hong Kong. In Front Cell Neurosci, 2014
Axin is a scaffold protein that regulates neuronal differentiation and morphogenesis in vitro.
[β-Catenin: Structure, Function and Role in Malignant Transformation of Epithelial Cells].
Novitskii et al., In Vestn Ross Akad Med Nauk, 2014
Primary structure of β-catenin allows it to interact with many factors and ligands, including transcription factors, α-catenin, cadherin, Axin, Rho family GTPases, Bcl9 et al.
The cellular story of dishevelleds.
Pećina-Šlaus et al., Zagreb, Croatia. In Croat Med J, 2014
These multifunctional proteins, originally discovered in the fruit fly, through their different domains mediate complex signal transduction: DIX (dishevelled, axin) and PDZ (postsynaptic density 95, discs large, zonula occludens-1) domains serve for canonical beta-catenin signaling, while PDZ and DEP (dishevelled, Egl-10, pleckstrin) domains serve for non-canonical signaling.
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Lin et al., Xiamen, China. In Cell Metab, 2014
Under glucose starvation, the v-ATPase-Ragulator complex is accessible to AXIN/LKB1 for AMPK activation.
AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.
Lin et al., Xiamen, China. In Cell Metab, 2013
Here, we show that it is AMP, but not ADP, that drives AXIN to directly tether LKB1 to phosphorylate AMPK.
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.
He et al., Boston, United States. In Science, 2013
The Axin scaffold and associated glycogen synthase kinase-3 (GSK3) have central roles in both assemblies, but the transduction mechanism from the receptor to the destruction complex is contentious.
GSK3β/axin-1/β-catenin complex is involved in semaphorin3A signaling.
Goshima et al., Yokohama, Japan. In J Neurosci, 2012
Phosphorylation of axin-1 by glycogen synthase kinase(GSK)-3beta accelerates the association of axin-1 with beta-catenin.
In pulmonary sclerosing hemangioma expression of β-catenin, Axin, and C-myc differs between the two cell types.
Wang et al., Shenyang, China. In Virchows Arch, 2012
respiratory epithelial polygonal and cuboidal cells have distinct expression of beta-catenin, Axin, and C-myc
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Clevers et al., Utrecht, Netherlands. In Cell, 2012
Results demonstrate that beta-catenin is not only phosphorylated inside the APC/Axin1 destruction complex, but also ubiquinated and degraded via the proteasome, all within an intact Axin1 complex.
Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells.
Sun et al., Chicago, United States. In Plos One, 2011
Axin1 apparently has a preventive effect on bacterial invasiveness and inflammatory response during the early stages of infection. The results suggest a distinct biological function of Axin1 and Axin2 in infectious disease and intestinal inflammation
Clinical significance of axin and β-catenin protein expression in primary hepatocellular carcinomas.
Zhang et al., Zhanjiang, China. In Asian Pac J Cancer Prev, 2011
Low axin1 is associated with hepatocellular carcinoma.
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