gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Autism susceptibility candidate 2

AUTS2, Autism susceptibility candidate 2
Top mentioned proteins: CAN, HAD, SET, Pax5, POLYMERASE
Papers on AUTS2
Association between AUTS2 haplotypes and alcohol dependence in a Japanese population.
New
Iwahashi et al., Sagamihara, Japan. In Acta Neuropsychiatr, Feb 2016
OBJECTIVE: Recent genome-wide analysis has indicated that the autism susceptibility candidate 2 (AUTS2) gene is involved in the regulation of alcohol consumption.
Penetrance of pathogenic mutations in haploinsufficient genes for intellectual disability and related disorders.
New
Wienker et al., Mainz, Germany. In Eur J Med Genet, Dec 2015
Apparently benign LOF variants were also detected in several other genes for ID and related disorders, including CDH15, KATNAL2, DEPDC5, ARID1B and AUTS2, both in the ExAC database and in the 6,500 exomes of the Exome Variant Server (http://evs.gs.washington.edu/EVS/).
Identification of disrupted AUTS2 and EPHA6 genes by array painting in a patient carrying a de novo balanced translocation t(3;7) with intellectual disability and neurodevelopment disorder.
New
Geneviève et al., Montpellier, France. In Am J Med Genet A, Dec 2015
Using microarray analysis, array painting (AP) technology combined with molecular study, we have identified the interruption of the autism susceptibility candidate 2 gene (AUTS2) and EPH receptor A6 gene (EPHA6).
Exonic deletions of AUTS2 in Chinese patients with developmental delay and intellectual disability.
New
Yu et al., Shanghai, China. In Am J Med Genet A, Dec 2015
Increasing evidences suggest copy number variations (CNVs) of autism susceptibility candidate gene 2 (AUTS2) are associated with a syndromic form of developmental delay and intellectual disability.
AUTS2 is a potential therapeutic target for pancreatic cancer patients with liver metastases.
New
Huang et al., Hangzhou, China. In Med Hypotheses, Aug 2015
In this study, we show that (A) AUTS2 is overexpressed in liver metastases of pancreatic cancer and could be a biomarker for defining cancer subtypes.
De novo exon 1 deletion of AUTS2 gene in a patient with autism spectrum disorder and developmental delay: a case report and a brief literature review.
New
Gai et al., China. In Am J Med Genet A, Jun 2015
Exonic deletions disrupting the autism susceptibility candidate 2 (AUTS2) gene have been demonstrated as causal variants leading to neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and developmental delay (DD).
Fetal DNA methylation of autism spectrum disorders candidate genes: association with spontaneous preterm birth.
New
Menon et al., Atlanta, United States. In Am J Obstet Gynecol, Apr 2015
STUDY DESIGN: A literature search for genes that have been implicated in ASD yielded 14 candidate genes (OXTR, SHANK3, BCL2, RORA, EN2, RELN, MECP2, AUTS2, NLGN3, NRXN1, SLC6A4, UBE3A, GABA, AFF2) that were epigenetically modified in relation to ASD.
An AUTS2-Polycomb complex activates gene expression in the CNS.
Impact
Reinberg et al., New York City, United States. In Nature, 2015
Naturally occurring variations of Polycomb repressive complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, autism susceptibility candidate 2 (AUTS2).
Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory.
Hoshino et al., Tokyo, Japan. In Plos One, 2014
Mutations in the Autism susceptibility candidate 2 gene (AUTS2) have been associated with a broad range of psychiatric illnesses including autism spectrum disorders, intellectual disability and schizophrenia.
A genome-wide association study of antidepressant response in Koreans.
Kim et al., Seoul, South Korea. In Transl Psychiatry, 2014
The two SNPs significantly associated with antidepressant response are rs7785360 and rs12698828 of the AUTS2 gene, located on chromosome 7 in 7q11.22.
The role of AUTS2 in neurodevelopment and human evolution.
Review
Ahituv et al., San Francisco, United States. In Trends Genet, 2013
The autism susceptibility candidate 2 (AUTS2) gene is associated with multiple neurological diseases, including autism, and has been implicated as an important gene in human-specific evolution.
Genetics and alcoholism.
Review
Foroud et al., Indianapolis, United States. In Nat Rev Gastroenterol Hepatol, 2013
Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2.
PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia.
Review
GeneRIF
Strehl et al., Vienna, Austria. In Leuk Res, 2012
PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia.
Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.
Impact
Gusella et al., Boston, United States. In Cell, 2012
We sequenced BCAs in patients with autism or related NDDs, revealing disruption of 33 loci in four general categories: (1) genes previously associated with abnormal neurodevelopment (e.g., AUTS2, FOXP1, and CDKL5), (2) single-gene contributors to microdeletion syndromes (MBD5, SATB2, EHMT1, and SNURF-SNRPN), (3) novel risk loci (e.g., CHD8, KIRREL3, and ZNF507), and (4) genes associated with later-onset psychiatric disorders (e.g., TCF4, ZNF804A, PDE10A, GRIN2B, and ANK3).
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
GeneRIF
Elliott et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2011
SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10(-8) to P = 4 x 10(-9)).
Disentangling the myriad genomics of complex disorders, specifically focusing on autism, epilepsy, and schizophrenia.
Review
Bourgeron et al., Utrecht, Netherlands. In Cytogenet Genome Res, 2010
We illustrate some of these mechanisms with a detailed analysis of recent studies of CNVs involving MCPH1, AUTS2, CNTNAP2, and mutations in GRIN2B.
A de novo balanced translocation breakpoint truncating the autism susceptibility candidate 2 (AUTS2) gene in a patient with autism.
GeneRIF
Milunsky et al., Boston, United States. In Am J Med Genet A, 2010
A de novo balanced translocation breakpoint truncating the autism susceptibility candidate 2 gene is associated with autism.
Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.
GeneRIF
Hevner et al., Seattle, United States. In Gene Expr Patterns, 2010
Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology.
share on facebooktweetadd +1mail to friends