GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
IplI-aurora-like kinase
Aurora B, Aurora B kinase, DmAurora B
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Papers using
Aurora B
antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on
Aurora B
Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.
New
Impact
Oklahoma City, United States. In Science, 01 Apr 2013
The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear.
The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.
New
Bordeaux, France. In Biochem Biophys Res Commun, 27 Mar 2013
Here we demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and we observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population.
S39, a novel Aurora B kinase inhibitor, shows potent antineoplastic activity in human Hela cervical cancer cell line.
New
Shanghai, China. In Biotechnol Lett, 27 Mar 2013
S39 is a novel potent inhibitor of Aurora B kinase with the IC(50) 90.07 nM in the biochemical assay in an ATP competitive manner.
Alternariol induces abnormal nuclear morphology and cell cycle arrest in murine RAW 264.7 macrophages.
New
Oslo, Norway. In Toxicol Lett, 26 Mar 2013
AOH treatment also induced abnormal Aurora B bridges, suggesting that cytokinesis was interfered within cells undergoing karyokinesis.
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21 (Cip1).
New
Madrid, Spain. In Cell Cycle, 21 Mar 2013
By using conditional knockout cells and chemical inhibition, we show here that inactivation of Aurora B results in delayed G₁/S transition and premature mitotic exit.
Expression patterns of cell cycle proteins in the livers of rats treated with hepatocarcinogens for 28 days.
New
Fuchū, Japan. In Arch Toxicol, 15 Mar 2013
All hepatocarcinogens, irrespective of their cytomegaly inducing potential, increased liver cells immunoreactive for p21(Cip1), which acts on cells arrested in G(1) phase, and for Aurora B or Incenp, which is suggestive of an increase in a cell population with chromosomal instability caused by overexpression.
Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo.
New
Florence, Italy. In Cancer Lett, 01 Mar 2013
Depletion or re-expression of MARCKS inhibited proliferation with a reduction in expression of the mitotic regulator Aurora B kinase (AURKB), whereas AURKB-depletion did not modify MARCKS expression.
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
Review
New
Impact
Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, Dec 2012
Aurora B is one of the most intensively studied kinases.
The budding yeast cdc48(shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (glc7).
New
Würzburg, Germany. In Plos One, Dec 2012
We demonstrate that shp1 mutants possess a perturbed balance of Glc7 phosphatase and Ipl1 (Aurora B) kinase activities and show that hyper-phosphorylation of the kinetochore protein Dam1, a key mitotic substrate of Glc7 and Ipl1, is a critical defect in shp1.
Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission.
Review
New
Impact
Worcester, United States. In Nat Rev Mol Cell Biol, Aug 2012
Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.
Cell division control by the Chromosomal Passenger Complex.
Review
New
Utrecht, Netherlands. In Exp Cell Res, Aug 2012
The Chromosomal Passenger Complex (CPC) consisting of Aurora B kinase, INCENP, Survivin and Borealin, is essential for genomic stability by controlling multiple processes during both nuclear and cytoplasmic division.
ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C.
New
Impact
London, United Kingdom. In Science, May 2012
Accordingly, CHMP4C functioned in the Aurora B-dependent abscission checkpoint to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage.
Spindle checkpoint silencing: PP1 tips the balance.
Review
Leuven, Belgium. In Curr Biol, 2011
Recent studies reveal that protein kinase Aurora B is a key regulator of spindle checkpoint activation whereas protein phosphatase PP1 antagonizes Aurora B and induces checkpoint silencing.
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.
Impact
New York City, United States. In Nat Cell Biol, 2011
Consistent with this, multiple kinases, including Aurora B and Plk1, are enriched at kinetochores of mal-oriented chromosomes when compared with bi-oriented chromosomes, which have stable attachments.
New prognostic markers and potential therapeutic targets in human testicular germ cell tumors.
Review
Napoli, Italy. In Curr Med Chem, 2010
In the last years novel markers, including OCT3/4, SOX2, SOX17, HMGA1, HMGA2, PATZ1, GPR30, Aurora B, and others has given further advantages to discriminate between histological subgroups.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
