Nucleosome functions in spindle assembly and nuclear envelope formation.
New York City, United States. In Bioessays, Oct 2015
Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit.
Feedback control of chromosome separation by a midzone Aurora B gradient.
Porto, Portugal. In Science, 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.