Erythroblast enucleation is a dynein-dependent process.
Akita, Japan. In Exp Hematol, 24 Jan 2016
We found that EHNA, a dynein inhibitor, and monastrol, a kinesin Eg5 inhibitor, as well as various inhibitors of MTOC regulators, including ON-01910 (Plk-1), MLN8237 (aurora A), hesperadin (aurora B) and LY294002 (PI3K) all inhibited CFU-E cytokinesis.
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Los Angeles, United States. In Front Oncol, 2014
Here, we fill a gap in the characterization of Aurora kinase inhibitors by using biochemical and cell-based assays to systematically profile a panel of 10 commercially available compounds with reported selectivity for Aurora A (MLN8054, MLN8237, MK-5108, MK-8745, Genentech Aurora Inhibitor 1), Aurora B (Hesperadin, ZM447439, AZD1152-HQPA, GSK1070916), or Aurora A/B (VX-680).
Feedback control of chromosome separation by a midzone Aurora B gradient.
Porto, Portugal. In Science, 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.