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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, V1a
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.
New
Impact
Ellenberg et al., Heidelberg, Germany. In Nat Biotechnol, 30 Apr 2015
We also analyzed the cell-cycle-dependent dynamics of the mitotic kinase complex Aurora B/INCENP and showed how a rise in Aurora concentration triggers two-step complex formation.
Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.
New
Impact
Tanaka et al., Oxford, United Kingdom. In Nat Cell Biol, 30 Apr 2015
To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast).
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe.
New
Poon et al., Hong Kong, Hong Kong. In Oncotarget, 20 Apr 2015
Using concentrations of inhibitors that did not induce severe mitotic defects on their own, we found that both the metaphase arrest and mitotic slippage induced by inhibitors targeting Aurora A and Aurora B (MK-5108 and Barasertib respectively) were enhanced by a PLK1 inhibitor (BI 2536).
Synthesis and biological evaluation of 2,4-diaminopyrimidines as selective Aurora A kinase inhibitors.
New
Hui et al., Lanzhou, China. In Eur J Med Chem, 20 Apr 2015
Compound 11c had more than 35-fold more selectivity for Aurora A over Aurora B, and molecular docking analysis indicated that compound 11c form better interaction with Aurora A both from the perspective of structure and energy.
Therapeutic potential of mitotic interaction between the nucleoporin Tpr and Aurora kinase A.
New
Wong et al., Kanazawa, Japan. In Cell Cycle, 19 Apr 2015
Mechanistically, Tpr interacts, via its central domain, with Aurora A but not Aurora B kinase.
Aurora B prevents chromosome arm separation defects by promoting telomere dispersion and disjunction.
New
Tournier et al., Toulouse, France. In J Cell Biol, 16 Apr 2015
Most of these defects are corrected before anaphase onset by a mechanism involving Aurora B kinase, a key regulator of mitosis in a wide range of organisms.
The aurora kinases in cell cycle and leukemia.
Review
New
Crispino et al., Chicago, United States. In Oncogene, Mar 2015
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
New
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, Dec 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.
Review
New
Lee et al., Singapore, Singapore. In Front Cell Dev Biol, Dec 2014
Recent studies reveal that controlling CPC localization and Aurora B kinase activity also serves as a key surveillance mechanism for the orderly mitotic exit.
Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
New
Taylor et al., Toledo, United States. In Nat Commun, Dec 2014
The existence of a pool of CPC at the kinetochore suggests that error correction is more complicated than predicted from the Aurora B phosphorylation gradient model.
Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).
Review
New
Coumar et al., Zhengzhou, China. In Expert Opin Ther Pat, Sep 2014
Preliminary evidence suggests that the use of selective Aurora A inhibitors could avoid Aurora B-mediated neutropenia in clinical settings.
An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.
Review
New
Chieffi et al., Caserta, Italy. In Histol Histopathol, Aug 2014
For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies.
Feedback control of chromosome separation by a midzone Aurora B gradient.
New
Impact
Maiato et al., Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
New
Impact
Stenmark et al., Oslo, Norway. In Nat Cell Biol, Jun 2014
During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells with chromosome segregation defects.
Interplay between mitotic kinesins and the Aurora kinase-PP1 (protein phosphatase 1) axis.
Review
Meadows, Coventry, United Kingdom. In Biochem Soc Trans, 2013
The Aurora B kinase, which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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