Minimal model for collective kinetochore-microtubule dynamics.
Philadelphia, United States. In Proc Natl Acad Sci U S A, 13 Nov 2015
We present a minimal model for collective kinetochore-MT dynamics, based on in vitro measurements of individual MTs and their dependence on force and kinetochore phosphorylation by Aurora B kinase.
Spatial gradients controlling spindle assembly.
Bloomington, United States. In Biochem Soc Trans, Feb 2015
In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.
The dynamic protein Knl1 - a kinetochore rendezvous.
Québec, Canada. In J Cell Sci, Sep 2014
We present emerging roles of the protein interaction motifs present in Knl1, including the RVSF, SILK, MELT and KI motifs, and their role in the recruitment and regulation of the SAC proteins Bub1, BubR1, Bub3 and Aurora B. Finally, we explore how the regions of low structural complexity that characterize Knl1 are implicated in the cooperative interactions that mediate binding partner recognition and scaffolding activity by Knl1.
Feedback control of chromosome separation by a midzone Aurora B gradient.
Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.