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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2015.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, V1a
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
MALDI-mass spectrometric imaging reveals hypoxia-driven lipids and proteins in a breast tumor model.
New
Glunde et al., In Anal Chem, 20 Jun 2015
In this study we identified hypoxia-regulated proteins active in several distinct pathways such as glucose metabolism, regulation of actin cytoskeleton, protein folding, translation/ribosome, splicesome, the PI3K-Akt signaling pathway, hemoglobin chaperone, protein processing in endoplasmic reticulum, detoxification of reactive oxygen species, aurora B signaling/apoptotic execution phase, the RAS signaling pathway, the FAS signaling pathway/caspase cascade in apoptosis and telomere stress induced senescence.
ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission.
New
Ullman et al., Salt Lake City, United States. In Mol Biol Cell, 22 May 2015
UNASSIGNED: Aurora B regulates cytokinesis timing and plays a central role in the abscission checkpoint.
Aurora B Kinase Promotes Cytokinesis by Inducing Centralspindlin Oligomers that Associate with the Plasma Membrane.
New
Glotzer et al., Chicago, United States. In Dev Cell, 20 May 2015
In metazoans, cytokinesis is triggered by activation of the GTPase RhoA at the equatorial plasma membrane.
High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.
New
Impact
Ellenberg et al., Heidelberg, Germany. In Nat Biotechnol, 30 Apr 2015
We also analyzed the cell-cycle-dependent dynamics of the mitotic kinase complex Aurora B/INCENP and showed how a rise in Aurora concentration triggers two-step complex formation.
Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.
New
Impact
Tanaka et al., Oxford, United Kingdom. In Nat Cell Biol, 30 Apr 2015
To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast).
The aurora kinases in cell cycle and leukemia.
Review
New
Crispino et al., Chicago, United States. In Oncogene, Mar 2015
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
A chromosomal passenger complex protein signature model predicts poor prognosis for non-small-cell lung cancer.
New
Deng et al., Shanghai, China. In Onco Targets Ther, Dec 2014
METHODS: The expression levels of four CPC proteins - aurora B kinase (AURKB), borealin, inner centromere protein (INCENP), and survivin - were evaluated using immunohistochemistry in an independent cohort of NSCLC specimens.
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
New
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, Dec 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.
Review
New
Lee et al., Singapore, Singapore. In Front Cell Dev Biol, Dec 2014
Recent studies reveal that controlling CPC localization and Aurora B kinase activity also serves as a key surveillance mechanism for the orderly mitotic exit.
Reed-sternberg cells form by abscission failure in the presence of functional aurora B kinase.
New
Sambade et al., Porto, Portugal. In Plos One, Dec 2014
Large multinucleated Reed-Sternberg cells (RS) and large mononucleated Hodgkin cells (H) are traditionally considered to be the neoplastic population in classical Hodgkin lymphoma, (cHL) and postulated to promote the disease.
Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).
Review
New
Coumar et al., Zhengzhou, China. In Expert Opin Ther Pat, Sep 2014
Preliminary evidence suggests that the use of selective Aurora A inhibitors could avoid Aurora B-mediated neutropenia in clinical settings.
The dynamic protein Knl1 - a kinetochore rendezvous.
Review
New
Bolanos-Garcia et al., Québec, Canada. In J Cell Sci, Sep 2014
We present emerging roles of the protein interaction motifs present in Knl1, including the RVSF, SILK, MELT and KI motifs, and their role in the recruitment and regulation of the SAC proteins Bub1, BubR1, Bub3 and Aurora B. Finally, we explore how the regions of low structural complexity that characterize Knl1 are implicated in the cooperative interactions that mediate binding partner recognition and scaffolding activity by Knl1.
An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.
Review
New
Chieffi et al., Caserta, Italy. In Histol Histopathol, Aug 2014
For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies.
Feedback control of chromosome separation by a midzone Aurora B gradient.
New
Impact
Maiato et al., Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
New
Impact
Stenmark et al., Oslo, Norway. In Nat Cell Biol, Jun 2014
During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells with chromosome segregation defects.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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