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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, V1a
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
Multifunctional Human Transcriptional Co-activator Protein PC4 is a Substrate of Aurora Kinases and Activates the Aurora Enzymes.
New
Kundu et al., Bengaluru, India. In Febs J, 18 Feb 2016
A fraction of PC4 associates with Aurora A and Aurora B and undergoes phosphorylation, following which, PC4 activates both Aurora A and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery.
Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression.
New
Machado-Santelli et al., São Paulo, Brazil. In Oncotarget, 15 Feb 2016
It was observed mislocalization of Anillin, Aurora B, Septin 9 and Alix in the intercellular bridge, and no determination of secondary constriction and abscission sites.
Bistability of a coupled Aurora B kinase-phosphatase system in cell division.
New
Grishchuk et al., Philadelphia, United States. In Elife, 14 Feb 2016
UNASSIGNED: Aurora B kinase, a key regulator of cell division, localizes to specific cellular locations, but the regulatory mechanisms responsible for phosphorylation of substrates located remotely from kinase enrichment sites are unclear.
Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.
New
Sumara et al., Illkirch-Graffenstaden, France. In Dev Cell, 11 Feb 2016
UBASH3B interacts with ubiquitylated Aurora B, one of the main kinases regulating chromosome segregation, and controls its subcellular localization but not protein levels.
The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.
New
Hoskin et al., Halifax, Canada. In J Cell Biochem, 11 Feb 2016
Decreased phosphorylation of histone H3 at serine 10 in fisetin-treated TNBC cells at G2/M phase of the cell cycle suggested that fisetin-induced apoptosis was the result of Aurora B kinase inhibition.
Erythroblast enucleation is a dynein-dependent process.
New
Nunomura et al., Akita, Japan. In Exp Hematol, 24 Jan 2016
We found that EHNA, a dynein inhibitor, and monastrol, a kinesin Eg5 inhibitor, as well as various inhibitors of MTOC regulators, including ON-01910 (Plk-1), MLN8237 (aurora A), hesperadin (aurora B) and LY294002 (PI3K) all inhibited CFU-E cytokinesis.
Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint.
New
Huang et al., Guangzhou, China. In Cell Cycle, 17 Jan 2016
The Aurora B kinase plays a critical role in cell mitosis and spindle checkpoint.
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.
New
Liou et al., Singapore, Singapore. In Sci Rep, 31 Dec 2015
Phosphorylation of MCAK by Aurora B kinase, a component of the chromosomal passenger complex, significantly enhances the interaction of NuSAP with MCAK and modulates the effects of NuSAP on the depolymerisation activity of MCAK.
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
New
Impact
Friedberg et al., Seattle, United States. In J Clin Oncol, Aug 2015
Aurora B kinase was more commonly overexpressed than AAK in tumor specimens.
High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.
New
Impact
Ellenberg et al., Heidelberg, Germany. In Nat Biotechnol, Apr 2015
We also analyzed the cell-cycle-dependent dynamics of the mitotic kinase complex Aurora B/INCENP and showed how a rise in Aurora concentration triggers two-step complex formation.
Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.
New
Impact
Tanaka et al., Oxford, United Kingdom. In Nat Cell Biol, Apr 2015
To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast).
CHMP4C Disruption Sensitizes the Human Lung Cancer Cells to Irradiation.
Su et al., Beijing, China. In Int J Mol Sci, 2014
Radiation-induced Aurora B expression enhances CHMP4C phosphorylation in non-small cell lung cancer (NSCLC) cells, maintaining cell cycle check-point and cellular viability as well as resisting apoptosis.
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Shiau et al., Los Angeles, United States. In Front Oncol, 2014
Here, we fill a gap in the characterization of Aurora kinase inhibitors by using biochemical and cell-based assays to systematically profile a panel of 10 commercially available compounds with reported selectivity for Aurora A (MLN8054, MLN8237, MK-5108, MK-8745, Genentech Aurora Inhibitor 1), Aurora B (Hesperadin, ZM447439, AZD1152-HQPA, GSK1070916), or Aurora A/B (VX-680).
Feedback control of chromosome separation by a midzone Aurora B gradient.
Impact
Maiato et al., Porto, Portugal. In Science, 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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