Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe.
Hong Kong, Hong Kong. In Oncotarget, 20 Apr 2015
Using concentrations of inhibitors that did not induce severe mitotic defects on their own, we found that both the metaphase arrest and mitotic slippage induced by inhibitors targeting Aurora A and Aurora B (MK-5108 and Barasertib respectively) were enhanced by a PLK1 inhibitor (BI 2536).
The aurora kinases in cell cycle and leukemia.
Chicago, United States. In Oncogene, Mar 2015
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.
Caserta, Italy. In Histol Histopathol, Aug 2014
For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies.
Feedback control of chromosome separation by a midzone Aurora B gradient.
Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.