An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.
Caserta, Italy. In Histol Histopathol, Aug 2014
For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies.
The aurora kinases in cell cycle and leukemia.
Chicago, United States. In Oncogene, Apr 2014
UNLABELLED: The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: an overview.
Caserta, Italy. In J Cell Physiol, Aug 2013
Many discovered bio-markers including OCT3/4, SOX2, SOX17, HMGA1, HMGA2, PATZ1, GPR30, Aurora B, estrogen receptor β, and others have given further advantages to discriminate between histological subgroups.
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.
New York City, United States. In Chromosoma, Jun 2013
Erroneous microtubule attachment is destabilized by Aurora B-mediated phosphorylation of multiple microtubule-binding protein complexes at the kinetochore, such as the KMN network proteins and the Ska/Dam1 complex, while Plk-dependent phosphorylation of BubR1 stabilizes kinetochore-microtubule attachment by recruiting PP2A-B56.
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.
Brighton, United Kingdom. In Open Biol, Mar 2013
In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and these activities are often split between two different Aurora paralogues, termed Aurora A and B. Polar and equatorial functions of Aurora kinases have generally been considered separately, with Aurora A being mostly involved in centrosome dynamics, whereas Aurora B coordinates kinetochore attachment and cytokinesis.