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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 Nov 2014.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, PCNA
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
Sequential treatment with aurora B inhibitors enhances cisplatin-mediated apoptosis via c-Myc.
New
Yang et al., Hangzhou, China. In J Mol Med (berl), 21 Dec 2014
Here, we showed that compared to the non-functional traditional simultaneous treatment, sequential combination of Aurora B inhibitors followed by cisplatin synergistically enhanced apoptotic response in cisplatin-resistant OVCAR-8 cells.
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
New
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, 17 Dec 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.
New
Earnshaw et al., Montréal, Canada. In Open Biol, 30 Nov 2014
The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its conserved IN-box domain.
Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster.
New
Earnshaw et al., Marseille, France. In Open Biol, 30 Nov 2014
We have previously shown that Aurora B activates Polo kinase at the centromere in mitosis, and that the interaction between Polo and the chromosomal passenger complex (CPC) component INCENP is essential in this activation.
A new small-molecule Aurora B inhibitor shows antitumor activity in human cancer cell lines.
New
Yu et al., Shanghai, China. In Mol Biol Rep, 28 Nov 2014
The Aurora B inhibition of S4 treatment inhibited the phosphorylation of Histone H3 at serine 10 in HeLa and SMMC7721 cells.
Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.
New
Coumar et al., Pondicherry, India. In J Comput Aided Mol Des, 26 Nov 2014
Moreover, hit 7 was found to be selective for Aurora A (Aurora B IC50 = 35,150 nM) and the possible reasons for selectivity investigated by docking two tautomeric forms (2H- and 3H-pyrazole) of 7 in Auroras A and B (PDB ID: 4AF3) crystal structures.
Feedback control of chromosome separation by a midzone Aurora B gradient.
New
Impact
Maiato et al., Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
New
Impact
Stenmark et al., Oslo, Norway. In Nat Cell Biol, Jun 2014
During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells with chromosome segregation defects.
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
New
Impact
Durocher et al., Toronto, Canada. In Science, May 2014
Aberrantly controlled mitotic DSB repair leads to Aurora B kinase-dependent sister telomere fusions that produce dicentric chromosomes and aneuploidy, especially in the presence of exogenous genotoxic stress.
Cell division: control of the chromosomal passenger complex in time and space.
Review
New
Lens et al., Utrecht, Netherlands. In Chromosoma, Mar 2014
This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis.
A cascade of histone modifications induces chromatin condensation in mitosis.
New
Impact
Neumann et al., Göttingen, Germany. In Science, Feb 2014
Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear.
Interplay between mitotic kinesins and the Aurora kinase-PP1 (protein phosphatase 1) axis.
Review
New
Meadows, Coventry, United Kingdom. In Biochem Soc Trans, Dec 2013
The Aurora B kinase, which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint.
Knowing when to cut and run: mechanisms that control cytokinetic abscission.
Review
New
Martin-Serrano et al., London, United Kingdom. In Trends Cell Biol, Sep 2013
Additionally, we discuss the surveillance mechanism known as the Aurora B-mediated abscission checkpoint (NoCut), which prevents genetic damage by ensuring proper abscission delay when chromatin is trapped at the midbody.
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.
Review
New
Wynne et al., New York City, United States. In Chromosoma, Jun 2013
Erroneous microtubule attachment is destabilized by Aurora B-mediated phosphorylation of multiple microtubule-binding protein complexes at the kinetochore, such as the KMN network proteins and the Ska/Dam1 complex, while Plk-dependent phosphorylation of BubR1 stabilizes kinetochore-microtubule attachment by recruiting PP2A-B56.
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.
Review
New
Pereira-Leal et al., Brighton, United Kingdom. In Open Biol, Mar 2013
In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and these activities are often split between two different Aurora paralogues, termed Aurora A and B. Polar and equatorial functions of Aurora kinases have generally been considered separately, with Aurora A being mostly involved in centrosome dynamics, whereas Aurora B coordinates kinetochore attachment and cytokinesis.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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