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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Mar 2015.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, PCNA
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
BioEssays 3∕2015.
New
In Bioessays, 31 Mar 2015
This transition is spatially regulated by a spindle midzone Aurora B activity gradient (light pink) revealed by the gradual dephosphorylation of Histone H3 on Ser10 (green) as chromosomes (magenta) migrate towards the poles where nuclear envelope (cyan blue) reformation begins.
Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity.
New
Sánchez-Pacheco et al., Madrid, Spain. In J Hepatol, 27 Mar 2015
RESULTS: We show that HCV and core protein inhibit the phosphorylation of Serine 10 in histone 3. The inhibition is due to the direct interaction between HCV core and Aurora B kinase (AURKB) that results in a decrease of AURKB activity.
Dependency of 2-methoxyestradiol-induced mitochondrial apoptosis on mitotic spindle network impairment and prometaphase arrest in human Jurkat T cells.
New
Kim et al., Taegu, South Korea. In Biochem Pharmacol, 27 Mar 2015
The 2-MeO-E2-induced phosphorylation of Bcl-2 family proteins and mitochondrial apoptotic events were suppressed by a Cdk1 inhibitor, but not by an aurora B kinase (ARK1), Aurora B kinase (ARK2), JNK, or p38 MAPK inhibitor.
Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.
New
Rutka et al., Toronto, Canada. In Oncotarget, 20 Mar 2015
One of the key regulatory kinases involved in multiple stages of mitosis is Aurora kinase B. We hypothesized that medulloblastoma cells that overexpress MYC would be uniquely sensitized to the apoptotic effects of Aurora B inhibition.
MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase.
New
Kallio et al., Turku, Finland. In Mol Oncol, 27 Feb 2015
Here, we show that let-7b contributes to the maintenance of genomic balance via targeting Aurora B kinase, a key regulator of the spindle assembly checkpoint (SAC).
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
New
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, Dec 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).
Review
New
Coumar et al., Zhengzhou, China. In Expert Opin Ther Pat, Sep 2014
Preliminary evidence suggests that the use of selective Aurora A inhibitors could avoid Aurora B-mediated neutropenia in clinical settings.
Feedback control of chromosome separation by a midzone Aurora B gradient.
New
Impact
Maiato et al., Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.
New
Impact
Stenmark et al., Oslo, Norway. In Nat Cell Biol, Jun 2014
During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in cells with chromosome segregation defects.
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
New
Impact
Durocher et al., Toronto, Canada. In Science, May 2014
Aberrantly controlled mitotic DSB repair leads to Aurora B kinase-dependent sister telomere fusions that produce dicentric chromosomes and aneuploidy, especially in the presence of exogenous genotoxic stress.
The aurora kinases in cell cycle and leukemia.
Review
New
Crispino et al., Chicago, United States. In Oncogene, Apr 2014
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
Cell division: control of the chromosomal passenger complex in time and space.
Review
New
Lens et al., Utrecht, Netherlands. In Chromosoma, Mar 2014
This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis.
A cascade of histone modifications induces chromatin condensation in mitosis.
New
Impact
Neumann et al., Göttingen, Germany. In Science, Feb 2014
Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear.
Interplay between mitotic kinesins and the Aurora kinase-PP1 (protein phosphatase 1) axis.
Review
Meadows, Coventry, United Kingdom. In Biochem Soc Trans, 2013
The Aurora B kinase, which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint.
Knowing when to cut and run: mechanisms that control cytokinetic abscission.
Review
Martin-Serrano et al., London, United Kingdom. In Trends Cell Biol, 2013
Additionally, we discuss the surveillance mechanism known as the Aurora B-mediated abscission checkpoint (NoCut), which prevents genetic damage by ensuring proper abscission delay when chromatin is trapped at the midbody.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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