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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 26 Mar 2014.

IplI-aurora-like kinase

Aurora B, Aurora B kinase, DmAurora B
Top mentioned proteins: Aurora, Histone, CAN, INCENP, PCNA
Papers using Aurora B antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B
Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions.
New
Impact
Durocher et al., Toronto, Canada. In Science, 20 Apr 2014
Aberrantly controlled mitotic DSB repair leads to Aurora B-dependent sister telomere fusions that produce dicentric chromosomes and aneuploidy, especially in the presence of exogenous genotoxic stress.
EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells Against Ionizing Radiation.
New
Willers et al., Boston, United States. In Cancer Res, 19 Apr 2014
Aurora B promotes this process in a manner that is co-dependent upon EGFR and PKCa.
EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.
New
Stukenberg et al., Charlottesville, United States. In J Cell Biol, 17 Apr 2014
The Aurora B kinase coordinates kinetochore-microtubule attachments with spindle checkpoint signaling on each mitotic chromosome.
The aurora kinases in cell cycle and leukemia.
New
Crispino et al., Chicago, United States. In Oncogene, 17 Apr 2014
UNLABELLED: The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).
An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.
Review
New
Chieffi et al., Caserta, Italy. In Histol Histopathol, 13 Apr 2014
For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies.
Dissecting the first and the second meiotic divisions using a marker-less drug-hypersensitive fission yeast.
New
Kawashima et al., Tokyo, Japan. In Cell Cycle, 03 Apr 2014
We found that Aurora B/Ark1 kinase activity is required for recruitment of Bub1, an essential SAC kinase, to unattached kinetochore in prometaphase I and prometaphase II as in mitosis.
A cascade of histone modifications induces chromatin condensation in mitosis.
New
Impact
Neumann et al., Göttingen, Germany. In Science, 03 Feb 2014
Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear.
Genome-wide Transcriptional Sequencing Identifies Novel Mutations in Metabolic Genes in Human Hepatocellular Carcinoma.
New
Buetow et al., Rockville, United States. In Cancer Genomics Proteomics, Jan 2014
Network analysis of expression data identified the Aurora B signaling, FOXM1 transcription factor network and Wnt signaling pathways pairs being altered in HCC.
Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.
New
Impact
Desai et al., San Diego, United States. In Science, Jan 2014
The kinetochore dynein module directly regulated Ndc80, independently of phosphorylation by Aurora B kinase, and this regulation was required for accurate segregation.
Knowing when to cut and run: mechanisms that control cytokinetic abscission.
Review
New
Martin-Serrano et al., London, United Kingdom. In Trends Cell Biol, Sep 2013
Additionally, we discuss the surveillance mechanism known as the Aurora B-mediated abscission checkpoint (NoCut), which prevents genetic damage by ensuring proper abscission delay when chromatin is trapped at the midbody.
Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: an overview.
Review
New
Chieffi et al., Caserta, Italy. In J Cell Physiol, Aug 2013
Many discovered bio-markers including OCT3/4, SOX2, SOX17, HMGA1, HMGA2, PATZ1, GPR30, Aurora B, estrogen receptor β, and others have given further advantages to discriminate between histological subgroups.
Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.
Review
New
Wynne et al., New York City, United States. In Chromosoma, Jun 2013
Erroneous microtubule attachment is destabilized by Aurora B-mediated phosphorylation of multiple microtubule-binding protein complexes at the kinetochore, such as the KMN network proteins and the Ska/Dam1 complex, while Plk-dependent phosphorylation of BubR1 stabilizes kinetochore-microtubule attachment by recruiting PP2A-B56.
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
New
Impact
Desai et al., San Diego, United States. In Nature, Jun 2013
Biorientation is ensured by Aurora B kinase (Ipl1), a member of the four-subunit chromosomal passenger complex (CPC).
Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.
New
Impact
Dawson et al., Oklahoma City, United States. In Science, Apr 2013
The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules so that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear.
Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle.
Review
New
Pereira-Leal et al., Brighton, United Kingdom. In Open Biol, Mar 2013
In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and these activities are often split between two different Aurora paralogues, termed Aurora A and B. Polar and equatorial functions of Aurora kinases have generally been considered separately, with Aurora A being mostly involved in centrosome dynamics, whereas Aurora B coordinates kinetochore attachment and cytokinesis.
Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.
GeneRIF
Eggert et al., In Acs Chem Biol, 2010
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
GeneRIF
Carmena et al., Cambridge, United States. In Dev Cell, 2006
INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis.
GeneRIF
Gatti et al., Roma, Italy. In J Cell Biol, 2003
This protein accumulates at the mid-zones of chromosome-free spindles.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
GeneRIF
González et al., Heidelberg, Germany. In Embo J, 2002
Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability.
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