In Bioessays, 31 Mar 2015
This transition is spatially regulated by a spindle midzone Aurora B activity gradient (light pink) revealed by the gradual dephosphorylation of Histone H3 on Ser10 (green) as chromosomes (magenta) migrate towards the poles where nuclear envelope (cyan blue) reformation begins.
Feedback control of chromosome separation by a midzone Aurora B gradient.
Porto, Portugal. In Science, Aug 2014
A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome decondensation by retaining Condensin I. PP1/PP2A phosphatases counteracted this gradient and promoted chromosome decondensation and NER.
The aurora kinases in cell cycle and leukemia.
Chicago, United States. In Oncogene, Apr 2014
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C (AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and AURKB) and meiosis (AURKC).