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Aurora kinase B

Aurora B kinase
kinase; involved in proper progression of cytokinesis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Aurora, Histone, CAN, INCENP, V1a
Papers using Aurora B kinase antibodies
The c-myc Insulator Element and Matrix Attachment Regions Define the c-myc Chromosomal Domain.
Supplier
Chadwick Brian P., In PLoS ONE, 2002
... cdk inhibitors or mitosis kinase inhibitors: 50 mM of hydroxyurea (Tocris Bioscience), 1 mM of the Aurora B Kinase inhibitor ZM447439 (Tocris Bioscience) or 100 nM ...
Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product
Supplier
Cimini Daniela, In PLoS ONE, 1989
... Aurora B kinase inhibitor, ZM447439 (Tocris Biosciences, USA), was dissolved ...
Papers on Aurora B kinase
Bistability of a coupled Aurora B kinase-phosphatase system in cell division.
New
Grishchuk et al., Philadelphia, United States. In Elife, Feb 2016
UNASSIGNED: Aurora B kinase, a key regulator of cell division, localizes to specific cellular locations, but the regulatory mechanisms responsible for phosphorylation of substrates located remotely from kinase enrichment sites are unclear.
The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.
New
Hoskin et al., Halifax, Canada. In J Cell Biochem, Feb 2016
Decreased phosphorylation of histone H3 at serine 10 in fisetin-treated TNBC cells at G2/M phase of the cell cycle suggested that fisetin-induced apoptosis was the result of Aurora B kinase inhibition.
Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint.
New
Huang et al., Guangzhou, China. In Cell Cycle, Jan 2016
The Aurora B kinase plays a critical role in cell mitosis and spindle checkpoint.
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.
New
Liou et al., Singapore, Singapore. In Sci Rep, Dec 2015
Phosphorylation of MCAK by Aurora B kinase, a component of the chromosomal passenger complex, significantly enhances the interaction of NuSAP with MCAK and modulates the effects of NuSAP on the depolymerisation activity of MCAK.
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
New
Impact
Friedberg et al., Seattle, United States. In J Clin Oncol, Aug 2015
Aurora B kinase was more commonly overexpressed than AAK in tumor specimens.
Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.
New
Impact
Tanaka et al., Oxford, United Kingdom. In Nat Cell Biol, Apr 2015
To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast).
Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch.
Bollen et al., Leuven, Belgium. In Nat Commun, 2014
During (pro)metaphase, RepoMan-associated protein phosphatases PP1 and PP2A-B56 regulate the chromosome targeting of Aurora-B kinase and RepoMan, respectively.
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.
Review
Lee et al., Singapore, Singapore. In Front Cell Dev Biol, 2014
Recent studies reveal that controlling CPC localization and Aurora B kinase activity also serves as a key surveillance mechanism for the orderly mitotic exit.
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.
Review
Musacchio et al., Dortmund, Germany. In Front Oncol, 2014
Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation.
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
Impact
Durocher et al., Toronto, Canada. In Science, 2014
Aberrantly controlled mitotic DSB repair leads to Aurora B kinase-dependent sister telomere fusions that produce dicentric chromosomes and aneuploidy, especially in the presence of exogenous genotoxic stress.
Cell division: control of the chromosomal passenger complex in time and space.
Review
Lens et al., Utrecht, Netherlands. In Chromosoma, 2014
This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis.
A cascade of histone modifications induces chromatin condensation in mitosis.
Impact
Neumann et al., Göttingen, Germany. In Science, 2014
Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear.
Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.
Impact
Desai et al., San Diego, United States. In Science, 2014
The kinetochore dynein module directly regulated Ndc80, independently of phosphorylation by Aurora B kinase, and this regulation was required for accurate segregation.
Interplay between mitotic kinesins and the Aurora kinase-PP1 (protein phosphatase 1) axis.
Review
Meadows, Coventry, United Kingdom. In Biochem Soc Trans, 2013
The Aurora B kinase, which is bound to the inner centromere during early mitosis, plays a central role in both chromosome bi-orientation and the spindle checkpoint.
[The research progress of Aurora-B kinase and its inhibitors].
Review
Yang et al., Tianjin, China. In Yao Xue Xue Bao, 2013
There were several Aurora-B kinase inhibitors which had entered the clinics and displayed good antitumor activity.
Inhibition of Aurora kinases perturbs chromosome alignment and spindle checkpoint signaling in rat spermatocytes.
GeneRIF
Kallio et al., Turku, Finland. In Exp Cell Res, 2006
Results suggest that the activities of Aurora kinases A and B are required for normal spindle assembly as well as for establishment and maintenance of proper microtubule-kinetochore attachments and spindle checkpoint signaling in male mammalian meiosis.
Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression.
GeneRIF
Ravid et al., Boston, United States. In Blood, 2004
when overexpressed in megakaryocytes of transgenic mice, the phenotype includes increased transgenic mRNA, but not protein, in polyploidy megakaryocytes, further suggesting that Aurora-B is regulated at the protein level.
Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis.
GeneRIF
Wang et al., Worcester, United States. In Mol Biol Cell, 2002
Aurora B kinase during mitosis and cytokinesis
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