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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

AURKA aurora kinase A

Top mentioned proteins: Aurora, CAN, p53, HAD, Aura
Papers using AURKA antibodies
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
El-Rifai Wael et al., In Oncogene, 1997
... expression plasmid for AURKA was generated by PCR amplification of the full-length coding sequence of AURKA and cloned in frame into pcDNA3.1 (Invitrogen Life Technologies).
Papers on AURKA
Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment.
Richmond et al., The Valley, Anguilla. In J Natl Cancer Inst, Jun 2016
METHODS: Tumor senescence was induced by AURKA or CDK4/6 inhibitors (AURKAi, CDK4/6i).
Expression of aurora kinase A correlates with the Wnt-modulator RACGAP1 in gastric cancer.
Malfertheiner et al., Magdeburg, Germany. In Cancer Med, Feb 2016
The aim of this study was to identify the link between Wnt signaling and aurora kinase A (AURKA), a target for the treatment of gastrointestinal cancers.
Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.
Ng et al., Melbourne, Australia. In Cell Cycle, Jan 2016
Here we investigate the signalling interactions between WDR62 and the mitotic kinase Aurora A (AURKA) that has been recently shown to cooperate to control brain size in mice.
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Crispino et al., Chicago, United States. In Nat Med, Dec 2015
Here we show through pharmacologic and genetic studies that aurora kinase A (AURKA) represents a new therapeutic target in PMF.
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
Liu et al., Dalian, China. In Nat Commun, Dec 2015
Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events.
Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells.
Zhou et al., Daliang, China. In Int J Mol Sci, Dec 2015
Alisertib (ALS) is a selective Aurora kinase A (AURKA) inhibitor with unclear effect and molecular interactome on CRC.
Targeting Mitosis in Cancer: Emerging Strategies.
Mak et al., Toronto, Canada. In Mol Cell, Dec 2015
This reasoning stimulated our development of novel inhibitors targeting the critical regulators of genomic stability and the mitotic checkpoint: AURKA, PLK4, and Mps1/TTK.
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis.
Diskin et al., Philadelphia, United States. In Cancer Cell, Dec 2015
Further, we demonstrate a convergence of LIN28B and RAN signaling on Aurora kinase A activity.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
For these family members, additional mechanisms of action have been defined in receptor tyrosine kinase (RTK) signaling, estrogen receptor signaling or cell cycle progression, involving discrete partner proteins such as SHC, NSP proteins, or AURKA.
Lineage specificity of primary cilia in the mouse embryo.
Anderson et al., New York City, United States. In Nat Cell Biol, Feb 2015
Basal bodies in XEN cells are mature and can form cilia when the AURKA-HDAC6 cilium disassembly pathway is inhibited.
Functions of Aurora kinase C in meiosis and cancer.
Schindler et al., United States. In Front Cell Dev Biol, 2014
The mammalian genome encodes three Aurora kinase protein family members: A, B, and C. While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte).
Aurora kinase A in gastrointestinal cancers: time to target.
El-Rifai et al., Nashville, United States. In Mol Cancer, 2014
During the last two decades, several studies have shown amplification and overexpression of Aurora kinase A (AURKA) in several GI malignancies.
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.
Guarguaglini et al., Roma, Italy. In Front Oncol, 2014
The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic entry to cytokinesis.
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
Bastians et al., Göttingen, Germany. In Nat Cell Biol, 2014
This phenotype is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in 73% of human colorectal cancers.
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.
Crispino et al., Chicago, United States. In Cell, 2012
An integrated target identification approach employing proteomic and shRNA screening revealed that a major target of diMF is Aurora kinase A (AURKA).
Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
Uzbekov et al., Tours, France. In Biol Reprod, 2008
Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.
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